全ゲノムを対象とした網膜格子状変性感受性遺伝子のマイクロサテライトマッピング

2010 年度 研究成果報告書

• 研究課題/領域番号: 20592052
• 研究種目: 基盤研究(C)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 眼科学
• 研究機関: 横浜市立大学
• 研究代表者: 伊藤 典彦 横浜市立大学, 医学部, 助教 (80264654)
• 研究分担者: 水木 信久 横浜市立大学, 医学研究科, 教授 (90336579)
• 連携研究者: 大野 重昭 北海道大学, 医学研究科, 特任教授 (50002382) ; 猪子 英俊 東海大学, 医学部, 教授 (10101932)
• 研究期間 (年度): 2008 – 2010
• キーワード: ゲノムワイド相関解析 / マイクロサテライト / SNP / 網膜格子状変性

研究概要

網膜格子状変性の疾患感受性遺伝子を網羅的に同定するため、日本人網膜格子状変性患者574検体および日本人健常者608検体を対象に、全染色体を網羅する23,465個のマイクロサテライトマーカーを用いてゲノムワイドな遺伝子スクリーニングを行い、網膜格子状変性と有意に相関する疾患感受性遺伝子を同定した。

研究成果

• [雑誌論文] Investigation of Association between TLR9 Gene Polymorphisms and VKH in Japanese Patients. (2011)
  • 著者名/発表者名: Ito R, Ota M, Meguro A, Katsuyama Y, Uemoto R, Nomura E, Nishide T, Kitaichi N, Horie Y, Namba K, Ohno S, Inoko H, Mizuki N.
  • 雑誌名: Ocul Immunol Inflamm 19(3) ページ: 202-205
• [雑誌論文] Investigation of the association between SLC1A3 gene polymorphisms and normal tension glaucoma. (2011)
  • 著者名/発表者名: Yasumura R, Meguro A, Ota M, Nomura E, Uemoto R, Kashiwagi K, Mabuchi F, Iijima H, Kawase K, Yamamoto T, Nakamura M, Negi A, Sagara T, Nishida T, Inatani M, Tanihara H, Aihara M, Araie M, Fukuchi T, Abe H, Higashide T, Sugiyama K, Kanamoto T, Kiuchi Y, Iwase A, Ohno S, Inoko H, Mizuki N.
  • 雑誌名: Mol Vis 17 ページ: 792-796
• [雑誌論文] Toll-like receptor 2 (TLR2) gene polymorphisms are not associated with sarcoidosis in the Japanese. (2011)
  • 著者名/発表者名: Sato M, Kawagoe T, Meguro A, Ota M, Katsuyama Y, Ishihara M, Namba K, Kitaichi N, Morimoto S, Kaburaki T, Ando Y, Takenaka S, Ohno S, Inoko H, Mizuki N.
  • 雑誌名: Mol Vis 17 ページ: 731-736
• [雑誌論文] Association analysis of Toll-like receptor 7 gene polymorphisms and Behcet's disease in Japanese. (2011)
  • 著者名/発表者名: Sada T, Ota M, Katsuyama Y, Meguro A, Nomura E, Uemoto R, Nishide T, Okada E, Ohno S, Inoko H, Mizuki N.
  • 雑誌名: Hum Immunol 72(3) ページ: 269-272
• [雑誌論文] Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behcet's disease susceptibility loci. (2010)
  • 著者名/発表者名: Mizuki N, Meguro A, Ota M, Ohno S, Shiota T, Kawagoe T, Ito N, Kera J, Okada E, Yatsu K, Song YW, Lee EB, Kitaichi N, Namba K, Horie Y, Takeno M, Sugita S, Mochizuki M, Bahram S, Ishigatsubo Y, Inoko H.
  • 雑誌名: Nat Genet 42(8) ページ: 703-706
• [雑誌論文] Genetics of Behcet disease inside and outside the MHC. (2010)
  • 著者名/発表者名: Meguro A, Inoko H, Ota M, Katsuyama Y, Oka A, Okada E, Yamakawa R, Yuasa T, Fujioka T, Ohno S, Bahram S, Mizuki N.
  • 雑誌名: Ann Rheum Dis 69(4) ページ: 747-754
• [雑誌論文] Genome-wide association study of normal tension glaucoma : common variants in SRBD1 and ELOVL5 contribute to disease susceptibility. (2010)
  • 著者名/発表者名: Meguro A, Inoko H, Ota M, Mizuki N, Bahram S, Writing Committee for the Normal Tension Glaucoma Genetic Study Group of Japan Glaucoma Society.
  • 雑誌名: Ophthalmology 117(7) ページ: 1331-1338
• [雑誌論文] Genotyping HLA-DRB1 and HLA-DQB1 alleles in Japanese patients with normal tension glaucoma. (2010)
  • 著者名/発表者名: Suzuki M, Meguro A, Ota M, Nomura E, Kato T, Nomura N, Kashiwagi K, Mabuchi F, Iijima H, Kawase K, Yamamoto T, Nakamura M, Negi A, Sagara T, Nishida T, Inatani M, Tanihara H, Aihara M, Araie M, Fukuchi T, Abe H, Higashide T, Sugiyama K, Kanamoto T, Kiuchi Y, Iwase A, Ohno S, Inoko H, Mizuki N.
  • 雑誌名: Mol Vis 16 ページ: 1874-1879
• [雑誌論文] TRIM39 and RNF39 are associated with Behcet's disease independently of HLA-B*51 and -A*26. (2010)
  • 著者名/発表者名: Kurata R, Nakaoka H, Tajima A, Hosomichi K, Shiina T, Meguro A, Mizuki N, Ohono S, Inoue I, Inoko H.
  • 雑誌名: Biochem Biophys Res Commun 401(4) ページ: 533-537
• [雑誌論文] Eicosapentaenoic acid suppresses ocular inflammation in endotoxin-induced uveitis. (2010)
  • 著者名/発表者名: Suzuki M, Noda K, Kubota S, Hirasawa M, Ozawa Y, Tsubota K, Mizuki N, Ishida S.
  • 雑誌名: Mol Vis. 16 ページ: 1382-1388
• [雑誌論文] Natural killer cells control a T-helper 1 response in patients with Behcet's disease. (2010)
  • 著者名/発表者名: Yamaguchi Y, Takahashi H, Satoh T, Okazaki Y, Mizuki N, Takahashi K, Ikezawa Z, Kuwana M.
  • 雑誌名: Arthritis Res Ther 12(3) ページ: R80
• [雑誌論文] Analysis of microsatellite polymorphisms within the GLC1F locus in Japanese patients with normal tension glaucoma. (2010)
  • 著者名/発表者名: Murakami K, Meguro A, Ota M, Shiota T, Nomura N, Kashiwagi K, Mabuchi F, Iijima H, Kawase K, Yamamoto T, Nakamura M, Negi A, Sagara T, Nishida T, Inatani M, Tanihara H, Aihara M, Araie M, Fukuchi T, Abe H, Higashide T, Sugiyama K, Kanamoto T, Kiuchi Y, Iwase A, Ohno S, Inoko H, Mizuki N.
  • 雑誌名: Mol Vis 16 ページ: 462-466
• [雑誌論文] Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth. (2009)
  • 著者名/発表者名: Albuquerque RJ, Hayashi T, Cho WG, Kleinman ME, Dridi S, Takeda A, Baffi JZ, Yamada K, Kaneko H, Green MG, Chappell J, Wilting J, Weich HA, Yamagami S, Amano S, Mizuki N, Alexander JS, Peterson ML, Brekken RA, Hirashima M, Capoor S, Usui T, Ambati BK, Ambati J.
  • 雑誌名: Nat Med 15(9) ページ: 1023-1030
• [雑誌論文] Association of microsatellite polymorphisms of the GPDS1 locus with normal tension glaucoma in the Japanese population. (2009)
  • 著者名/発表者名: Nakamura K, Ota M, Meguro A, Nomura N, Kashiwagi K, Mabuchi F, Iijima H, Kawase K, Yamamoto T, Nakamura M, Negi A, Sagara T, Nishida T, Inatani M, Tanihara H, Aihara M, Araie M, Fukuchi T, Abe H, Higashide T, Sugiyama K, Kanamoto T, Kiuchi Y, Iwase A, Ohno S, Inoko H, Mizuki N.
  • 雑誌名: Clin Ophthalmol 3 ページ: 307-312
• [雑誌論文] Investigation of the association between the GLC3A locus and normal tension glaucoma in Japanese patients by microsatellite analysis. (2009)
  • 著者名/発表者名: Kamio M, Meguro A, Ota M, Nomura N, Kashiwagi K, Mabuchi F, Iijima H, Kawase K, Yamamoto T, Nakamura M, Negi A, Sagara T, Nishida T, Inatani M, Tanihara H, Aihara M, Araie M, Fukuchi T, Abe H, Higashide T, Sugiyama K, Kanamoto T, Kiuchi Y, Iwase A, Ohno S, Inoko H, Mizuki N.
  • 雑誌名: Clin Ophthalmol 3 ページ: 183-188
• [雑誌論文] Association of TLR4 polymorphisms with Behcet's disease in a Korean population. (2009)
  • 著者名/発表者名: Horie Y, Meguro A, Ota M, Kitaichi N, Katsuyama Y, Takemoto Y, Namba K, Yoshida K, Song YW, Park KS, Lee EB, Inoko H, Mizuki N, Ohno S.
  • 雑誌名: Rheumatology 48(6) ページ: 638-642
• [雑誌論文] Investigation of the association between Toll-like receptor 2 gene polymorphisms and Behcet's disease in Japanese patients. (2009)
  • 著者名/発表者名: Tomiyama R, Meguro A, Ota M, Katsuyama Y, Nishide T, Uemoto R, Iijima Y, Ohno S, Inoko H, Mizuki N.
  • 雑誌名: Hum Immunol 70(1) ページ: 41-44
• [雑誌論文] Association of toll-like receptor 2 gene polymorphisms with normal tension glaucoma. (2009)
  • 著者名/発表者名: Nakamura J, Meguro A, Ota M, Nomura E, Nishide T, Kashiwagi K, Mabuchi F, Iijima H, Kawase K, Yamamoto T, Nakamura M, Negi A, Sagara T, Nishida T, Inatani M, Tanihara H, Aihara M, Araie M, Fukuchi T, Abe H, Higashide T, Sugiyama K, Kanamoto T, Kiuchi Y, Iwase A, Ohno S, Inoko H, Mizuki N.
  • 雑誌名: Mol Vis 15 ページ: 2905-2910
• [雑誌論文] Lack of association between toll-like receptor 4 gene polymorphisms and sarcoidosis-related uveitis in Japan. (2009)
  • 著者名/発表者名: Asukata Y, Ota M, Meguro A, Katsuyama Y, Ishihara M, Namba K, Kitaichi N, Morimoto S, Kaburaki T, Ando Y, Takenaka S, Inoko H, Ohno S, Mizuki N.
  • 雑誌名: Mol Vis 15 ページ: 2673-2682
• [雑誌論文] New susceptibility locus for high myopia is linked to the uromodulin-like 1 (UMODL1) gene region on chromosome 21q22.3. (2009)
  • 著者名/発表者名: Nishizaki R, Ota M, Inoko H, Meguro A, Shiota T, Okada E, Mok J, Oka A, Ohno S, Mizuki N.
  • 雑誌名: Eye 23(1) ページ: 222-229
• [雑誌論文] Association of the toll-like receptor 4 gene polymorphisms with Behcet's disease. (2008)
  • 著者名/発表者名: Meguro A, Ota M, Katsuyama Y, Oka A, Ohno S, Inoko H, Mizuki N.
  • 雑誌名: Ann Rheum Dis 67(5) ページ: 725-727
• [雑誌論文] Association of toll-like receptor 4 gene polymorphisms with normal tension glaucoma. (2008)
  • 著者名/発表者名: Shibuya E, Meguro A, Ota M, Kashiwagi K, Mabuchi F, Iijima H, Kawase K, Yamamoto T, Nakamura M, Negi A, Sagara T, Nishida T, Inatani M, Tanihara H, Aihara M, Araie M, Fukuchi T, Abe H, Higashide T, Sugiyama K, Kanamoto T, Kiuchi Y, Iwase A, Ohno S, Inoko H, Mizuki N.
  • 雑誌名: Invest Ophthalmol Vis Sci 49(10) ページ: 4453-4457
• [雑誌論文] Four-digit allele genotyping of HLA-A and HLA-B genes in Japanese patients with Behcet's disease. (2008)
  • 著者名/発表者名: Kamiishi T, Itoh Y, Meguro A, Nishida T, Sasaki S, Nanba K, Ohno S, Inoko H, Mizuki N.
  • 雑誌名: Nippon Ganka Gakkai Zasshi 112(5) ページ: 451-458
• [雑誌論文] A mouse model of allogeneic corneal endothelial cell transplantation. (2008)
  • 著者名/発表者名: Hayashi T, Yamagami S, Tanaka K, Yokoo S, Usui T, Amano S, Mizuki N.
  • 雑誌名: Cornea 27(6) ページ: 699-705
• [雑誌論文] Bilateral herpes simplex keratitis in a patient with chronic graft-versus-host disease. (2008)
  • 著者名/発表者名: Hayashi T, Ishioka M, Ito N, Kato Y, Nakagawa H, Hatano H, Mizuki N.
  • 雑誌名: Clin Ophthalmol 2(2) ページ: 457-459
• [雑誌論文] Guidelines for the diagnosis of ocular sarcoidosis. (2008)
  • 著者名/発表者名: Asukata Y, Ishihara M, Hasumi Y, Nakamura S, Hayashi K, Ohno S, Mizuki N.
  • 雑誌名: Ocul Immunol Inflamm 16(3) ページ: 77-81
• [雑誌論文] Rac1 mediates phorbol 12-myristate 13-acetate-induced migration of glioblastoma cells via paxillin. (2008)
  • 著者名/発表者名: Nomura N, Nomura M, Mizuki N, Hamada J.
  • 雑誌名: Oncol Rep 20(4) ページ: 705-711
• [雑誌論文] Association of reduced heme oxygenase-1 with excessive Toll-like receptor 4 expression in peripheral blood mononuclear cells in Behcet's disease. (2008)
  • 著者名/発表者名: Kirino Y, Takeno M, Watanabe R, Murakami S, Kobayashi M, Ideguchi H, Ihata A, Ohno S, Ueda A, Mizuki N, Ishigatsubo Y.
  • 雑誌名: Arthritis Res Ther 10(1) ページ: R16
• [学会発表] Genome-wide association study of lattice degeneration of the retina using 23,465 microsatellite markers. (2011)
  • 著者名/発表者名: Meguro A, Ideta H, Ota M, Ideta R, Inoko H, Mizuki N.
  • 学会等名: Asia Pacific Academy of Ophthalmology Congress 2011
  • 発表場所: Sydney, Australia
  • 年月日: 20110300