| 研究課題/領域番号 |
20F20113
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| 研究機関 | 順天堂大学 |
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研究代表者 |
鎌形 康司 順天堂大学, 医学部, 准教授 (60568153)
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| 研究分担者 |
ANDICA CHRISTINA 順天堂大学, 医学部, 外国人特別研究員
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| 研究期間 (年度) |
2020-04-24 – 2022-03-31
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| キーワード | Parkinson’s disease / Tremor dominant / Diffusion tensor imaging / Fixel-based analysis / Free-water imaging / Neurall plasticity / Neuroinflammation |
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| 研究実績の概要 |
We assessed the fiber-specific white matter (WM) alterations in patients with early-stage Parkinson’s disease (PD) with tremor dominant using fixel-based analysis. As a result, we provided evidence of WM neural compensation mechanisms marked by increases in neuronal fiber bundle size. In contrast, no such finding was found in PD patients with postural instability and gait disorder (minor revision of npj Parkinson’s disease journal). Using free-water imaging, we also showed neuroinflammation (indexed by increased free-water fractional volume fraction) in the substantia nigra pars compacta, temporal mesocortex, forceps major, and cingulum cingulate gyrus correlated with the motor assessment scale in patients with PD with GBA1 mutations (presented in 2021 ISMRM Annual Meeting & Exhibition).
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
In the first year, we have successfully evaluated the cross-sectional data of patients with early-stage Parkinson’s disease (PD) using advanced diffusion MRI techniques as planned. We have also considered different subtypes of PD, such as tremor dominant vs. postural instability and gait disorder and idiopathic PD vs. familial PD. Our findings provided important new insights into neuropathological changes (such as neuronal morphology alterations and neuroinflammation) associated with PD subtypes and showed the association between the changes and clinical scores. As scheduled, we have presented these findings at conferences and prepared the manuscripts.
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| 今後の研究の推進方策 |
As planned, we will evaluate the longitudinal data of Parkinson’s disease (PD) using advanced diffusion MRI techniques in the second year. In line with the cross-sectional study, we will also assess the longitudinal neuropathological changes of different subtypes of PD. We expect to publish more articles by the end of the fiscal year.
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