| 研究課題/領域番号 |
20J20737
|
|---|
| 研究機関 | 北海道大学 |
|---|
研究代表者 |
Abd Elwakil Mahmoud 北海道大学, 生命科学院, 特別研究員(DC1)
|
|---|
| 研究期間 (年度) |
2020-04-24 – 2023-03-31
|
| キーワード | mRNA drugs / Biomaterials / Gene Therapy / Organocatalysis / Lipid Nanoparticles / Lung diseases / Combinatorial chemistry |
|---|
| 研究実績の概要 |
We successfully engineered a novel chemical library based on monomers coming from sustainable sources to delivery mRNA drugs to the lungs after systemic administration without targeting ligands.
Interestingly we submitted:
1. A patent through Hokkaido university (Japanese Patent, Application No. 2021 007461,Hokudai No. P2020 126 TP01)
2. A research paper was submitted to the journal of Materials Horizons (IF= No.
MH COM 02 2021 000185 We received the reviewer comments and resent the revision.
|
| 現在までの達成度 (区分) |
現在までの達成度 (区分)
1: 当初の計画以上に進展している
理由
Although we are at the time of COVID-19, we were able to finish the whole synthesis and screening. Additionally we finished the patent work and submitted a paper. Furthermore, we expanded the synthesis and another library is being synthesized
|
| 今後の研究の推進方策 |
We intend to expand the design of chemical space, integrate AI and adapt high throughput screening methods to engineer the next generation personalized gene therapies for infectious diseases, cancer immunotherapies and neuromuscular disorders.
|
