| 研究課題/領域番号 |
20K06865
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| 研究機関 | 国立遺伝学研究所 |
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研究代表者 |
ZHU YAN 国立遺伝学研究所, 遺伝形質研究系, 助教 (50464235)
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| 研究期間 (年度) |
2020-04-01 – 2024-03-31
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| キーワード | Chain migration / Precerebellar neurons / Metabolic pathways |
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| 研究実績の概要 |
The aim of this research is to understand energy expenditure and the metabolic source that power chain neuronal migration during development. At the beginning of this funding period, We generated a mouse line with the knockout of a transcription factor that had been reported to promote OXPHOS metabolic pathway. During the past year, we have analyzed further this mouse line, with the aim to illuminate the temporal sequences and the morphological changes in the course of neuronal chain migration in our mutant mouse. Our evidence so far points to a role of this gene in the process when neurons switch from tangential to radial migration.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
4: 遅れている
理由
The progress of this study has been delayed, due to COVID related problems and emergent family duties.
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| 今後の研究の推進方策 |
(1) We would finalize the phenotype analysis in our mutant mice.
(2) We would perform in vitro whole brain culture combining with pharmacological reagents to understand how varying energy source might affect the mode of chain migration.
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| 次年度使用額が生じた理由 |
The incurring amount will be used for the execution of next year’s plan: including maintaining mouse colonies, purchasing pregnant mice, culture medium, pharmacological reagents and antibodies.
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