研究課題
During this fiscal year, I could reveal Dual effect of bleomycin on lung injury and mediastinal fat-associated lymphoid clusters (MFALCs). Also, we could reveal a possible Crosstalk of the Immune Cells within the Lung and MFALCs in papain induced- Lung Asthma-like Mouse Model. Additionally, we started new experiment for the effect of dexamethasone administration on the lung injury and MFALCs.
1: 当初の計画以上に進展している
Due to availability of chemicals from purchased from the previous year
We are planning to investigate the effect of bleomycin intranasal administration on the lung injury in the lymphoproliferative autoimmune mice model (MRL/Lpr mice) and their control strain (MRL/ MpJ mice). Also, we would like to clarify the ameliorative effect of dexamethasone on the autoimmune lung injury and MFALCs development. Moreover, We are planning to investigate the role of MFALCs in the progression of lung cancer in lung melanoma mice model. Furthermore, we would like to examine the possible immunotherapeutic effect of some lipid nanoparticle targeting immune cells within the MFALCs against lung cancer development.
We will use all the budget to cover publication fees (500000 Yen), Buying chemicals and mice (250000 yen), and attending domestic and international conference (250000 yen).
すべて 2022 2021
すべて 雑誌論文 (5件) (うち国際共著 5件、 査読あり 5件、 オープンアクセス 5件) 学会発表 (2件) (うち国際学会 1件、 招待講演 1件)
Int J Mol Sci .
巻: 22 (6878) ページ: 1-18
10.3390/ijms22136878
Front Immunol .
巻: 12 ページ: 1-17
10.3389/fimmu.2021.665100
Biomed Pharmacother
巻: 142:112029 ページ: 1-14
10.1016/j.biopha.2021.112029
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
巻: 263: 151714 ページ: 1-9
10.1016/j.aanat.2021.151714
Am J Transl Res
巻: 13(6) ページ: 5796-5814
