縦隔関連リンパ組織に着目したヒト呼吸器・心血管疾患の革新的な治療戦略研究

2022 年度 実績報告書

• 研究課題/領域番号: 20K07420
• 研究機関: 北海道大学
• 研究代表者: エレワ ヤセル 北海道大学, 獣医学研究院, 助教 (30782221)
• 研究分担者: 昆 泰寛 北海道大学, 獣医学研究院, 教授 (10178402) ; 市居 修 北海道大学, 獣医学研究院, 准教授 (60547769)
• 研究期間 (年度): 2020-04-01 – 2023-03-31
• キーワード: MFALCs / Bleomycin / Lung Injury / Autoimmune Disease / lymphoproliferative / mouse models

研究実績の概要

This year, we were able to clarify the effects of either dexamethasone or bleomycin on lung injury and mediastinal fat-related lymph nodes (MFALCs). We were able to publish these data in two international high-impact journals (Elewa et al. J. Mol. Sci.2, Elewa et al. 2022, Microscopy and Microanalysis). In addition, we have started a new experiment on the impact of lung cancer induction on the microenvironment in MFALC. By targeting such MFALCs, he suggested that we could provide innovative treatments for lung cancer.In addition, in the previous year, we conducted joint research with other researchers in the laboratory and other research institutions and we have published 2022 more papers from this collaboration.

研究成果

• [雑誌論文] Histopathological Impact of Bleomycin on Lung Injury and Development of Mediastinal Fat-Associated Lymphoid Clusters in the Lymphoproliferative Mouse Model (2022)
  • 著者名/発表者名: Elewa, Y. H. A., Ichii, O., Mohamed, S.K.A., Kon, Y.
  • 雑誌名: Microscopy and Microanalysis 巻: 28 ページ: 1664-1678
  • DOI: 10.1017/S1431927622000654
  • 査読あり / オープンアクセス / 国際共著
• [雑誌論文] The Ameliorative Effect of Dexamethasone on the Development of Autoimmune Lung Injury and Mediastinal Fat‐Associated Lymphoid Clusters in an Autoimmune Disease Mouse Model (2022)
  • 著者名/発表者名: Elewa, Y. H. A., Masum Md. A., Mohamed, S.K.A., Islam RM, Nakamura T., Ichii, O., Kon, Y
  • 雑誌名: Int. J. Mol. Sci. 巻: 23 ページ: 4449
  • DOI: 10.3390/ijms23084449
  • 査読あり / オープンアクセス / 国際共著
• [雑誌論文] Ureteral morphology and pathology during urolithiasis in cats (2022)
  • 著者名/発表者名: Ichii O, Oyamada K, Mizukawa H, Yokoyama N, Namba T, Otani Y, Elewa, Y. H. A., Sasaki N, Nakamura T, Kon Y.
  • 雑誌名: Research in Veterinary Science 巻: 151 ページ: 10-20
  • DOI: 10.1016/j.rvsc.2022.06.029
  • 査読あり / オープンアクセス / 国際共著
• [雑誌論文] Cellular infiltration, cytokines, and histopathology of skin lesions associated with different clinical forms and stages of naturally occurring lumpy skin disease in cattle (2022)
  • 著者名/発表者名: Badr Y., Noreldin A.E., Elewa Y.H.A., Ahmed M.S., Inoshima Y., Baker N.M., Aamer W.N., Abas O.M., Nayel M., Rahman Md. M., Elgendy E., Saleh A. G., El-neweshy M.S
  • 雑誌名: Comparative Immunology, Microbiology, and Infectious Diseases 巻: 90-91 ページ: 101894
  • DOI: 10.1016/j.cimid.2022.101894
  • 査読あり / オープンアクセス / 国際共著
• [雑誌論文] Oral supplementation of policosanol alleviates carbon tetra chloride- induced liver fibrosis in rats. (2022)
  • 著者名/発表者名: Zein N, Yassin F, Makled S, Alotaibi SS, Albogami SM, Hedeab GM, Batiha GE, Elewa Y.H.A
  • 雑誌名: Biomed Pharmacother 巻: 150 ページ: 113020
  • DOI: 10.1016/j.biopha.2022.113020
  • 査読あり / オープンアクセス / 国際共著
• [雑誌論文] Modified foreign body reaction to silicone imbedded in subcutaneous tissues by different mouse systemic immune conditions (2022)
  • 著者名/発表者名: Yamakawa T, Ichii O, Nakamura T, Namba T, Elewa, Y. H. A., Masum MA, Otani Y, Nishimura T, Kon Y.
  • 雑誌名: J Biomed Mater Res A. 巻: 110 ページ: 1921-1931
  • DOI: 10.1002/jbm.a.37425
  • 査読あり / オープンアクセス / 国際共著
• [雑誌論文] Genital organ-associated lymphoid tissues arranged in a ring in the mucosa of cow vaginal vestibules (2022)
  • 著者名/発表者名: Chuluunbaatar T, Ichii O, Masum MA, Namba T, Islam MR, Otani Y, Elewa, Y. H. A., Kon Y.
  • 雑誌名: Research in Veterinary Science 巻: 145 ページ: 147-158
  • DOI: 10.1016/j.rvsc.2022.02.011
  • 査読あり / オープンアクセス / 国際共著
• [雑誌論文] Close Association between Altered Urine-Urothelium Barrier and Tertiary Lymphoid Structure Formation in the Renal Pelvis during Nephritis (2022)
  • 著者名/発表者名: Ichii O, Hosotani M, Masum MA, Horino T, Otani Y, Namba T, Nakamura T, Elewa, Y. H. A., Sasaki N, Kon Y.
  • 雑誌名: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 巻: 33 ページ: 88-107
  • DOI: 10.1681/ASN.2021040575
  • 査読あり / オープンアクセス / 国際共著
• [学会発表] Mediastinal fat associated lymphoid clusters: A novel immune structure controlling respiratory diseases and intrathoracic immune hemostasis. (2022)
  • 著者名/発表者名: Y. H. A. Elewa, O. Ichii, S., Y. Kon
  • 学会等名: The 5th international Conference of Medical Analysis, Toxins, and IVF”
  • 国際学会 / 招待講演
• [学会発表] “Novel Fat Associated Lymphoid clusters with special focus on the CHICKEN AIR SACS AND MESENTERY: A HISTOMORPHOMETRICAL AND IMMUNOLOGICAL STUDY.” (2022)
  • 著者名/発表者名: Y. H. A. Elewa, Md Rashedul Islam, Sherif Kh. A. Mohamed.
  • 学会等名: The 17th College Scientific Conference of Faculty of Veterinary medicine, Zagazig University “Veterinary Medicine and One Health Concept”.
  • 国際学会 / 招待講演
• [備考] Research map
  • URL: https://researchmap.jp/YaserElewa?lang=en