| 研究課題/領域番号 |
20K08150
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| 研究機関 | 国立研究開発法人量子科学技術研究開発機構 |
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研究代表者 |
Jeffrey Kershaw 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 分子イメージング診断治療研究部, 主任研究員(任常) (50508801)
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| 研究期間 (年度) |
2020-04-01 – 2024-03-31
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| キーワード | OGSE / diffusion-weighted MRI / frequency domain / asymptotic behaviour |
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| 研究実績の概要 |
Most of our effort during the first year was aimed at clarifying how oscillating-gradient spin-echo diffusion-weighted MRI (OGSE-DWI) measurements should be interpreted. A manuscript was submitted to and accepted by the Journal of Magnetic Resonance. In the article we demonstrated that practical restrictions on the duration and number of oscillations of a real motion-probing gradient means that the technique has limited spectral resolution and range. A new signal equation was derived that naturally incorporates these restrictions, and it was found that there are several aspects of the new framework that distinguish it from the signal model conventionally used to analyse OGSE-DWI data.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
3: やや遅れている
理由
Although important progress has been made in preparing and publishing one article, we must say that we are not as far advanced as hoped. As well as the restrictions placed on us due to the COVID-19 pandemic, the reason for this is that revisions of our first manuscript were unexpectedly time-consuming. A difference of opinion with one of the reviewers of the manuscript on one small issue meant that four rounds of revision were required. Happily, the issue was finally resolved, and the paper was accepted.
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| 今後の研究の推進方策 |
Rather than moving directly on to the experimental component of the project, we have decided for the moment to continue developing our new signal framework for OGSE-DWI. The simple reason for this is the need for a rigorous method for analysing the data when it is eventually acquired. The present focus of our work is on the asymptotic high- and low-frequency limits of the signal. A second manuscript based on this work is in the advanced stages of preparation.
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| 次年度使用額が生じた理由 |
Due to the COVID-19 pandemic we have been unable to attend several conferences and the corresponding registration fees have therefore accrued.
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