| 研究実績の概要 |
We have explored the effect of High fat diet on lung repair after a fibrosis-inducing injury, focusing on the effect on lung stem cells. We previously reported that High fat diet delayed the contribution of alveolar stem cells in the repair process and delayed the resolution of inflammation and fibrosis compared to the standard diet. In these new studies, we have identified the specific role of bronchioalveolar stem cells in this delay. Bronchioalveolar stem cells are rare in the lung compared to alveolar cells, so identifying their critical influence on repair represents a major advance in our knowledge. We also examined the effect of various inhibitors of Fatty Acid Oxidation on the high fat diet-induced delay in alveolar repair and fibrosis resolution.
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