| 研究実績の概要 |
The discharge under atmospheric conditions is also commonly known as cold atmospheric plasma (CAP). CAP generates plenty of reactive chemical species, both short and long-lived reactive species. In the last few years, CAP use in cancer treatment has increased tremendously. Besides the reported achievements of CAP to treat cancer, CAP’s action is still not known entirely. Several early studies focused on the murine double minute 2 (Mdm2)& p53(tumor suppressor protein). However, the effect of CAP treatment on Mdm2 and p53 is absent from the literature from long time. In our study we investigated the structural changes in Mdm2, p53, and the Mdm2-p53 before and after possible plasma oxidation through molecular dynamic (MD) simulations. MD calculation revealed that the oxidized Mdm2 bounded or unbounded showed high flexibility that might increase the availability of tumor suppressor protein p53 in plasma-treated cells.
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