| 研究実績の概要 |
Immunoglobulin A (IgA) has an important role as the cornerstone of defensive immunity. The mammary gland of the mother produces antibodies after childbirth. Plasma cells migrate from the intestinal tract and increase IgA in milk. However, most of the changes in the amount of intestinal IgA and its role during the perinatal period is still unknown. Therefore, this study for the first time investigated the intestinal IgA production and its role in strengthening immunity during the perinatal period through tryptophan (Trp) supplementation.
Feces of mice fed with 0.5% Trp-added basal feed and basal feed over time were collected and the IgA concentration in the feces was measured. Six weeks after the start of feeding, the large intestine was collected to address the number of plasma cells. In addition, using mice born 6 to 8 weeks after the start of feeding, feces and milk were collected to measure IgA concentration. The large intestine and mammary gland were collected in the second week of breastfeeding, to investigate the number of plasma cells. Fecal IgA levels increased significantly in the Trp group after 4 weeks of feeding bottom. However, there was no significant difference in the number of plasma cells in the large intestine 6 weeks after the start of feeding. Trp is thought to increase IgA production from individual plasma cells via aryl hydrocarbon receptor (AHR). Fecal IgA levels also increased significantly in the Trp group during early and late pregnancy. Trp is highly demanding, suggesting that Trp can enhance immunity in the intestinal tract.
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