| 研究課題/領域番号 |
20K15756
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| 研究機関 | 京都大学 |
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研究代表者 |
Walinda Erik 京都大学, 医学研究科, 助教 (80782391)
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| 研究期間 (年度) |
2020-04-01 – 2022-03-31
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| キーワード | ubiquitin / polyubiquitin / binding domains |
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| 研究実績の概要 |
Ubiquitin chains and binding proteins were successfully purified. ITC and NMR experiments proceeded as anticipated. Future studies are on the way. MD simulations also indicate an interesting mechanism for the physiological implications of the competition mechanism.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
Thanks to acquisition of the new FPLC system "AKTA Go" all purification tasks have been successfully accomplished.
Assignments of A20 in the bound state have also been obtained and competition experiments are on the way.
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| 今後の研究の推進方策 |
Further verification of the competition between A20, NEMO, and HOIL-1L by ITC and NMR experiments are warranted.
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| 次年度使用額が生じた理由 |
Travel expenses could not be used because of the pandemic situation all over the world. Therefore, a substantial amount of travel expenses have been carried to over to the next fiscal year.
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