| 研究課題/領域番号 |
20K15838
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| 研究機関 | 東北大学 |
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研究代表者 |
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| 研究期間 (年度) |
2020-04-01 – 2024-03-31
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| キーワード | Jellyfish / Appetite / Evolution / Feeding / Neuropeptide |
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| 研究実績の概要 |
The main research achievement has been the publication of a research article entitled ‘On the origin of appetite: GLWamide in jellyfish represents an ancestral satiety neuropeptide’ in the international journal PNAS. This required additional experiments and analyses, as requested by the reviewers, including: (a) further characterization of the behavioral effects of GLWamide; (b) anatomical characterization of peptide-expressing neurons in Drosophila and Cladonema and (c) bioinformatic analysis of Cladonema G protein-coupled receptors. Following publication, I also built on the results by characterizing the effect of satiety in the jellyfish Cladonema in greater detail.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
3: やや遅れている
理由
Following further delays with the initial review process, I had to submit our article to a new journal. New reviewers were assigned to evaluate the work, which meant new experiments that needed to be carried out before acceptance.
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| 今後の研究の推進方策 |
Now that the findings regarding the role of GLWamide in jellyfish feeding regulation have been made public, I plan to turn my attention to other peptides that also play a role in this behavior. Specifically, I plan to pursue the following objectives: (a) characterize in detail the multiple effects of satiety on jellyfish feeding, expanding the previous work; (b) identify the nature of the satiety signal and the pathways necessary to convey it; (c) investigate the behavioral mechanisms by which the other identified peptides regulate feeding; (d) raise antibodies against these peptides to characterize their expression and (e) identify neurons driving satiety using an activity reporter.
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| 次年度使用額が生じた理由 |
Because of delays in the review process, some of the initially planned experiments had to be postponed to the next fiscal year.
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