| 研究実績の概要 |
This study provided new methods to access chiral chromanone lactones with potential biological activities. The developed approach involves copper-catalyzed asymmetric vinylogous addition of siloxyfurans or butenolide to chromones. By using chiral ligands, the diastereo- and enantioselective addition of copper vinylogous enolate to chromones can be controlled with high regio- and stereoselectivity. These approaches were used for the synthesis of various chromanone lactones and applied in the total synthesis of ent-blennolide B. Additionally, secalonic acid A was synthesized formally using ent-blennolide B as an intermediate.
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