研究実績の概要 |
In our previous study, we clarified the expression of STB/HAP1 in the forebrain and in the spinal cord. We also clarified the STB/HAP1 expression in the Myenteric plexus of enteric neurons. In the last year of this project, we were the first to clarify the characterization of HAP1-immunoreactive cells in reference to secretomotor and vasodilator submucosal neurons. Our current results reveal that HAP1 is expressed in all the secretomotor and vasodilator neurons. This study might reflect the involvement of HAP1 in the modulation of the secretomotor and vasodilator functions of submucosal neurons. Our present results lay an essential foundation for future studies that seek to clarify the physiological and pathological roles of HAP1 in the submucosal plexus of ENS.
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