| 研究実績の概要 |
This study has identified neurophysiological markers for depressive somatic symptoms. These markers include reduced low-frequency heart rate variability in photoplethysmography (PPG) signals and altered connectivity between the insula and anterior cingulate cortex in brain imaging data. In our final year, we delved into the potential of multiscale entropy in PPG signals as somatic symptom biomarkers. Our results highlight that multiscale increment entropy of spline-interpolated interbeat intervals also holds promise as a biomarker. In sum, our findings suggest that neurophysiological activity changes with somatic symptoms. Consequently, using multi-modal neurophysiological biomarkers may offer a more comprehensive way for assessing somatic symptoms compared to single-modal indicators.
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