| 研究課題/領域番号 |
20K20209
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| 研究機関 | 公益財団法人川崎市産業振興財団(ナノ医療イノベーションセンター) |
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研究代表者 |
LI JUNJIE 公益財団法人川崎市産業振興財団(ナノ医療イノベーションセンター), ナノ医療イノベーションセンター, 研究員 (80869892)
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| 研究期間 (年度) |
2020-04-01 – 2023-03-31
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| キーワード | immunotherapy / nanoreactors / pyroptosis / self-assembly / vesicles / tumor metabolism |
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| 研究実績の概要 |
1. We provided a general platform to engineer vesicular nanodevices with tunable permeability without trade-offs between structural integrity, flexibility, and functionality by integrating stimuli-responsive linkers into crosslinking membrane networks.
2. We found that glucose oxidase-loaded PICsomes could induce an immunostimulatory form of cell death (pyroptosis), which has the great potential for priming anti-tumor immunotherapy and opens new avenues for using GOD-loaded nanocarriers as a cancer treatment modality.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
The method to engineer vesicular nanoreactor already has been confirmed. The in vitro proof-of-concept therapeutic investigation also has been proved.
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| 今後の研究の推進方策 |
1. Preparation of glucose oxidase and lactate oxidase co-loaded nanoreactor and in vitro therapeutic investigation.
2. In vivo therapeutic investigation.
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| 次年度使用額が生じた理由 |
Some ELISA kits arrived institute later. The remaining amount will be used to buy ELISA kits.
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