| 研究実績の概要 |
The present study uses the 3-day dietary record(3DR) data and the 3D brain magnetic resonance imaging (MRI) images during a 10-year follow-up to elucidate (1) whether Japanese diet suppresses the total brain atrophy in cognitively normal individuals, and (2) which part(s) of the brain is affected.
Last year, we implemented the 10-year follow-up survey and collected part of the 10-year MRI images, and observed that green tea consumption was negatively associated with annual hippocampal volume change.
The main task this year to continue the 10-year follow-up survey to collect the 10-year MRI images.
The study conducted this year was based on existing 3DR data and 2-year MRI images. Among the middle-aged and older subjects who participated in the 6th and 7th survey of the NILS-LSA project, 1691 whose data on both the 3DR and the MRI images were available were included in the analyses. We examined the association between Japanese diet and annual change of brain volume. A 9-component weighted Japanese Diet Index score was calculated and annual changes in gray matter, transverse temporal, and superior temporal volume (mL/y) were estimated by T1-weighted brain MRI and FreeSurfer software. In the multivariable-adjusted general linear model, a higher wJDI9 score was negatively associated with annual change ratio of transverse temporal. On the other hand, no associations were observed for gray matter or superior temporal volume annual changes.
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