• 研究課題をさがす
  • 研究者をさがす
  • KAKENの使い方
  1. 課題ページに戻る

2020 年度 実施状況報告書

疾患スクリーニングのための生理的肝臓モデル培養系の構築

研究課題

研究課題/領域番号 20K22491
研究機関東京大学

研究代表者

DANOY MATHIEU  東京大学, 大学院工学系研究科(工学部), 助教 (90882621)

研究期間 (年度) 2020-09-11 – 2022-03-31
キーワードhiPSCs / HSCs / Liver / Disease / LSECs / Hepatocytes
研究実績の概要

Currently, optimization of the differentiation and culture and hiPSCs-derived HSCs is being performed.
More specifically, culture of the cells on oxygen-permeable membrane in the different conditions that are to be tested has been successful.
In the current state, while the differentiation process of HSCs poses no issue, we are looking into improving its efficacy to facilitate screening in different conditions.
Culture of the hepatocytes and hiPSCs-derived LSECs are already performed routinely in our laboratory.
The stimulation of coculture models for disease modeling was independently tested in our laboratory and seems to pose no problem with our cellular components.

現在までの達成度 (区分)
現在までの達成度 (区分)

2: おおむね順調に進展している

理由

The project has started upon granting 6 months ago and is going though with the adjustments usually required in the setup phase.

今後の研究の推進方策

The optimization of the cellular components is planned to be done by the end of summer.
Establishment of the coculture model will be done during fall and winter 2021.
Disease modeling with our cellular components was confirmed this year and drug screening will be done once the coculture model is established.

URL: 

公開日: 2021-12-27  

サービス概要 検索マニュアル よくある質問 お知らせ 利用規程 科研費による研究の帰属

Powered by NII kakenhi