A Combinatorial Approach Towards Multimetallic Artificial Receptors for Cancer-Related Biomarkers

2021 年度 実績報告書

• 研究課題/領域番号: 20K22552
• 研究機関: 東京工業大学
• 研究代表者: CATTI LORENZO 東京工業大学, 科学技術創成研究院, 助教 (50873478)
• 研究期間 (年度): 2020-09-11 – 2022-03-31
• キーワード: Molecular building block / Bromo-bissalicylaldehyde / Aqueous bioreceptor / Metal complex

研究実績の概要

The research led to the preparation of a new bromo-bissalicylaldehyde building block, which can be coupled to boronic acids/esters via standard Suzuki coupling conditions. Its attachment to metal complexes could in principle lead to new metal receptors for biomolecules in water using biomolecule-metal interactions. The advantage of the salicylaldehyde units over conventional aldehyde units is their increased stability against oxidation. The gained knowledge was utilized for the preparation of a review on artificial bioreceptors.

研究成果

• [雑誌論文] Aqueous polyaromatic receptors for biomolecules with high selectivity (2022)
  • 著者名/発表者名: Catti Lorenzo、Sumida Ryuki、Yoshizawa Michito
  • 雑誌名: Coordination Chemistry Reviews 巻: 460 ページ: 214460～214470
  • DOI: 10.1016/j.ccr.2022.214460
  • 査読あり / 国際共著
• [雑誌論文] Supramolecular Singlet Fission of Pentacene Dimers within Polyaromatic Capsules (2021)
  • 著者名/発表者名: Catti Lorenzo、Narita Haruna、Tanaka Yuya、Sakai Hayato、Hasobe Taku、Tkachenko Nikolai V.、Yoshizawa Michito
  • 雑誌名: Journal of the American Chemical Society 巻: 143 ページ: 9361～9367
  • DOI: 10.1021/jacs.0c13172
  • 査読あり / 国際共著
• [雑誌論文] An Aromatic Micelle‐Based Saccharide Cluster with Changeable Fluorescent Color and its Protein Interactions (2021)
  • 著者名/発表者名: Narita Haruna、Catti Lorenzo、Yoshizawa Michito
  • 雑誌名: Angewandte Chemie International Edition 巻: 60 ページ: 12791～12795
  • DOI: 10.1002/anie.202102547
  • 査読あり / 国際共著
• [雑誌論文] Expanding the Protecting Group Scope for the Carbonyl Olefin Metathesis Approach to 2,5-Dihydropyrroles (2021)
  • 著者名/発表者名: Huck Fabian、Catti Lorenzo、Reber Gian Lino、Tiefenbacher Konrad
  • 雑誌名: The Journal of Organic Chemistry 巻: 87 ページ: 419～428
  • DOI: 10.1021/acs.joc.1c02447
  • 査読あり / 国際共著
• [学会発表] Pyridinium Core Units for V-shaped Anthracene Dimers: Rapid Access to New Polyaromatic Amphiphiles (2022)
  • 著者名/発表者名: Lorenzo Catti, Michito Yoshizawa
  • 学会等名: The 102nd CSJ Annual Meeting (2022)
  • 国際学会
• [学会発表] Saccharide modification of an aromatic micelle and its guest-dependent fluorescence in water (2021)
  • 著者名/発表者名: Lorenzo Catti, Haruna Narita, Michito Yoshizawa
  • 学会等名: Pacifichem 2021
  • 国際学会
• [学会発表] Reversible photoswitch-controlled structure transitions of biomolecules and their real-time visualization by high-speed atomic force microscopy (2021)
  • 著者名/発表者名: Lorenzo Catti, Holger Flechsig, Noriyuki Kodera, Mark J. MacLachlan, Shigehisa Akine
  • 学会等名: The 101st CSJ Annual Meeting (2021)
  • 国際学会