研究課題
By long term lineage tracing, we found that the fast-cycling epidermal stem cells are depleted during chronological skin aging while the slow-cycling counterparts are maintained. Interestingly, fibulin 7 ECM expression which is localized to the epidermal basement membrane, is reduced in aged skin. Mice lacking fibulin 7 expression exhibited early skin aging-like traits such as loss of fast-cycling stem cells, alterations in basement membrane-associated proteins such as Collagen IV, laminins and Collagen XVII, and aberrant differentiation state. Mechanistically, fibulin 7 keeps a slower epidermal stem cell proliferation in the young adult skin and this may contribute to minimize the accumulation of replication stress and early stem cell depletion.
すべて 2022 その他
すべて 雑誌論文 (1件) (うち国際共著 1件、 査読あり 1件、 オープンアクセス 1件) 学会発表 (2件) (うち国際学会 1件、 招待講演 1件) 備考 (2件)
EMBO reports
巻: 23(12) ページ: e55478
10.15252/embr.202255478
https://ircms.kumamoto-u.ac.jp/publications/2022/10/the-extracellular-matrix-fibulin-7-maintains-epidermal-stem-cell-heterogeneity-during-skin-aging.html
https://www.kumamoto-u.ac.jp/whatsnew/seimei-sentankenkyu/20221024-2
