| 研究実績の概要 |
Components of the Troponin protein complex are involved in the regulation of muscle contraction. However, much is left unknown about possible abnormalities due to their deficiency. This study analyses how a Troponin complex gene is regulated during embryonic development and is elucidating its unexplored functions in embryonic development and disease. we have obtained various data including their phenotypes at the level of skeletal muscle structure, as well as defects of the lymphatic system in embryos. We will study the mechanisms of abnormalities in troponin mutant embryos based on two hypotheses: (1)The defects of sarcomeric Troponin impair skeletal muscle contractility and result in abnormal phenotypes, and (2) The troponin elicits non-sarcomeric actions mainly in the embryonic skeletal muscle, which are fundamental to prevent abnormalities observed in mutant mice.
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