| 研究課題/領域番号 |
20KK0338
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| 研究機関 | 東北大学 |
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研究代表者 |
Rashad Sherif 東北大学, 医学系研究科, 助教 (00824088)
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| 研究期間 (年度) |
2020 – 2022
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| キーワード | Glioma / tRNA / CRISPR / Chemotherapy / Epigenetics |
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| 研究実績の概要 |
Studying Glioma epitranscriptome is a novel field of research. Here, I will study the dynamic tRNA epitranscriptome involved in Glioma chemotherapeutic responses to evaluate tRNA dynamics that influence this process and to develop future therapies for Glio ma. Glioma cell lines will be exposed to various chemotherapeutic agents and studied for changes in tRNA levels and modification s using mass spectrometry and sequencing. Moreover, CRISPR screens will be used to identify potential targets for therapy that w ill be explored via genetic approaches.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
Experiments are progressing smoothly and initial results shall be available within few months. CRISPR screening is progressing smoothly. Sequencing experiments are also progressing smoothly.
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| 今後の研究の推進方策 |
The next stage will focus on analysis of CRISPR screening results as well as RNA sequencing results to discover novel regulators for ferroptosis and the role that tRNA Biology plays in that process in glioma.
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