| 研究実績の概要 |
Joined the Dedon Laboratory in MIT starting February 2022 as intended in the research plan. Currently focusing on techniques related to tRNA modification analysis and how to apply these techniques to study glioma in basic and clinical research. In this project, I identified 2 tRNA methylation modifications that play important role in glioma pathogenesis, m1A and m7G. Either modification impacted glioma cell proliferation, protein synthesis, and response to ferroptosis and chemotherapy. The enzyme responsible for m1A modifications in glioma is currently being studied using animal models of glioma, cell model systems, and in silico screening for drug discovery. The enzyme responsible for m7G modifications is currently being studied using cell culture systems and animal models of glioma.
In a separate effort, I Identified epitranscriptional factors that regulate ferroptosis in glioma. The article is currently under review.
I also conducted genome wide CRISPR screening to identify regulators of ferroptosis in glioma cells. The screen led to the identifications of translational processes such as Ribosome collision and tRNA aminoacylation as important regulators of ferroptosis in glioma. These processes are currently under research.
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