脳磁図のガンマ帯域活動解析による統合失調症の脳部位間ネットワーク異常の検討

2012 年度 研究成果報告書

• 研究課題/領域番号: 21591516
• 研究種目: 基盤研究(C)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 精神神経科学
• 研究機関: 大阪大学
• 研究代表者: 石井 良平 大阪大学, 医学系研究科, 助教 (40372619)
• 研究分担者: 岩瀬 真生 大阪大学, 医学系研究科, 助教 (60362711) ; 武田 雅俊 大阪大学, 医学系研究科, 教授 (00179649)
• 研究期間 (年度): 2009 – 2012
• キーワード: 統合失調症 / 脳磁図 / ガンマ帯域活動 / ネットワーク異常 / 脆弱性遺伝子

研究概要

ワーキングメモリ課題を用いて誘発される脳磁場活動を測定した。時系列解析を用いてガンマ帯域活動(γBA)を抽出し、空間フィルタ法を用いて活動源の推定を行った。その結果、高周波帯域である 50-80Hz の帯域においては,encoding 区間で SCZ 群は HC群に比し上頭頂小葉にて有意な ERS の低下が認められ,retention 区間では後頭葉および左背外側前頭前野にて SCZ 群では ERD が,HC 群では ERS が認められ,両群で有意差が認められた.作業記憶に関連するとされる左背外側前頭前野での記憶の保持に関して HC 群で神経活動が増強し,SCH 群では減弱していることが示唆された.

研究成果

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• [学会発表] Cognitive and psychopathological disturbance in schizophrenia-like epilepsy psychosis: a neuroimaging magnetoencephalography study (2011)
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• [学会発表] Mirror neuron system dysfunction in autistic spectrum disorder revealed by spatial filtered magnetic encephalography . (2010)
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• [学会発表] Working memory-induced activation and severity of psychopathology in schizophrenia-like psychosis of epilepsy: evidence from magnetoencephalography (2010)
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• [学会発表] Frontal lobe dysfunction and regional hemodynamic changes in major depression: A near infrared spectroscopy study (2010)
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• [学会発表] Abnormal cortical oscillatory activity in schizophrenia-like psychosis of epilepsy after resection of meningioma (2010)
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  • 学会等名: The 8th Asian & Oceanian Epilepsy Congress
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  • 学会等名: 9th World Congress of Biological Psychiatry Paris
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• [学会発表] Hypofrontality in schizophrenia detected by the measurement of tissue oxygeneation index using NIRS (2009)
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