FAKシグナルを標的とした癌誘発骨破壊病変に対する新たな治療戦略の開発

2011 年度 研究成果報告書

• 研究課題/領域番号: 21689050
• 研究種目: 若手研究(A)
• 配分区分: 補助金
• 研究分野: 外科系歯学
• 研究機関: 岡山大学
• 研究代表者: 志茂 剛 岡山大学, 大学院・医歯薬学総合研究科, 助教 (40362991)
• 研究期間 (年度): 2009 – 2011
• キーワード: FAK / 破骨細胞 / 癌骨浸潤

研究概要

Focal adhesion kinase(FAK)は様々な悪性腫瘍において過剰発現し,特に浸潤・転移能の高い細胞において高発現することが報告されているものの,癌骨破壊巣におけるその役割は今だ不明な点が多い。そこで本研究では癌骨破壊病変におけるFAKの役割について検討し, FAKシグナルは破骨細胞形成,骨吸収能に大きく関与し,癌骨破壊病変に対し標的となる可能性が示唆された。

研究成果

• [雑誌論文] Anti-tumor effect of a novel FAK inhibitor TAE226 against human oral squamous cell carcinoma (2012)
  • 著者名/発表者名: Naito Kurio, Tsuyoshi Shimo, Takuya Fukazawa, Tatsuo Okui, Nur Mohammad Monsur Hassan, Tatsuki Honami, Yuu Horikiri, Shinji Hatakeyama, Munenori Takaoka, Yoshio Naomoto, Akira Sasaki
  • 雑誌名: Oral Oncology 巻: (accepted)
  • 査読あり
• [雑誌論文] Effect of a novel FAK inhibitor TAE226 on the breast cancer associated with bone metastasis (2011)
  • 著者名/発表者名: Naito Kurio, Tsuyoshi Shimo, Takuya Fukazawa, Munenori Takaoka, Tatsuo Okui, Nur Mohammad Monsur Hassan, Tatsuki Honami, Shinji Hatakeyama, Masahiko Ikeda, Yoshio Naomoto, Akira Sasaki
  • 雑誌名: Experimental Cell Research 巻: 317(8) ページ: 1134-1146
  • 査読あり
• [雑誌論文] Mechanism of cancer-induced bone destruction : An association of connective tissue growth factor(CTGF/CCN2) in the bone metastasis (2011)
  • 著者名/発表者名: Tsuyoshi Shimo, Akira Sasaki
  • 雑誌名: Jap Dental Science Review 巻: 47(1) ページ: 13-22
  • 査読あり
• [雑誌論文] Sonic Hedgehog Signaling Promotes Growth of Oral Squamous Cell Carcinoma Cells Associated with Bone Destruction (2011)
  • 著者名/発表者名: Tatsuki Honami, Tsuyoshi Shimo, Tatsuo Okui, Naito Kurio, Nur Mohammad Monsur Hassan, Masahiro Iwamoto, Akira Sasaki
  • 雑誌名: Oral Oncology 巻: 48(1) ページ: 49-55
  • 査読あり
• [雑誌論文] Induction of MMP-13 Expression in Bone-metastasizing Cancer Cells by Type I Collagen through Integrinα1β1 andα2β1-p38 MAPK Signaling (2011)
  • 著者名/発表者名: Soichiro Ibaragi, Tsuyoshi Shimo, Masahiro Iwamoto, Nur Mohammad Monsur Hassan, Sachiko Isowa, Naito Kurio, Hiroki Mandai, Shinichi Kodama, Akira Sasaki.
  • 雑誌名: Anticancer Research 巻: 31(4) ページ: 1307-1314
  • 査読あり
• [雑誌論文] Anti-tumor Effect of Temsirolimus against Oral Squamous Cell Carcinoma Associated with Bone Destruction (2010)
  • 著者名/発表者名: Tatsuo Okui, Tsuyoshi Shimo, Takuya Fukazawa, Naito Kurio, Nur Mohammad Monsur Hassan, Tatsuki Honami, Munenori Takaoka, Yoshio Naomoto, Akira Sasaki
  • 雑誌名: Molecular Cancer Therapeutics 巻: 9(11)
  • 査読あり
• [雑誌論文] PTHrP regulates angiogenesis and bone resorption via VEGF expression (2010)
  • 著者名/発表者名: Sachiko Isowa, Tsuyoshi Shimo, Soichiro Ibaragi, Naito Kurio, Tatsuo Okui, Kiminori Matsubara, Nur Mohammad Monsur Hassan, Koji Kishimoto, Akira Sasaki.
  • 雑誌名: Anticancer Research 巻: 30(7) ページ: 2755-2767
  • 査読あり
• [雑誌論文] Bone destruction by invading oral squamous carcinoma cells mediated by the transforming growth factor-βsignaling pathway (2010)
  • 著者名/発表者名: Takeshi Goda, Tsuyoshi Shimo, Yasuto Yoshihama, Nur Mohammad Monsur Hassan, Soichiro Ibaragi, Naito Kurio, Tatsuo Okui, Tatsuki Honami, Koji Kishimoto, Akira Sasaki
  • 雑誌名: Anticancer Research 巻: 30(7) ページ: 2615-2623
  • 査読あり
• [雑誌論文] Parathyroid hormone-related peptide regulates matrix metalloproteinase-13 gene expression in bone metastatic breast cancer cells (2010)
  • 著者名/発表者名: Soichiro Ibaragi, Tsuyoshi Shimo, Masahiro Iwamoto, Nur Mohammad Monsur Hassan, Shinichi Kodama, Sachiko Isowa, and Akira Sasaki
  • 雑誌名: Anticancer Research 巻: 30(12) ページ: 5029-5036
  • 査読あり
• [学会発表] Anti-tumor effect of a novel FAK inhibitor TAE226 against human oral squamous cell carcinoma (2012)
  • 著者名/発表者名: Naito Kurio, Tsuyoshi Shimo, Nur Mohammad Monsur Hassan, Tatsuo Okui, Tatsuki Honami, Shinji Hatakeyama, Munenori Takaoka, Yoshio Naomoto, Akira Sasaki
  • 学会等名: The 5th International Symposium for Future Technology Creating Better Human Health and Society
  • 発表場所: Okayama
  • 年月日: 20120315-16
• [学会発表] A Novel Focal Adhesion Kinase Inhibitor TAE226 Suppresses Parathyroid Related Protein Induced Hypercalcemia and Reduced Osteoclast Activation (2010)
  • 著者名/発表者名: Naito Kurio, Tsuyoshi Shimo, Nur Mohammad Monsur Hassan, Tatsuo Okui, Tatsuki Honami, Shinji Hatakeyama, Munenori Takaoka, Yoshio Naomoto, Akira Sasaki
  • 学会等名: The 3rd International Symposium for Future Technology Creating Better Human Health and Society
  • 発表場所: Okayama
  • 年月日: 20100203-04
• [学会発表] Inhibition of Focal Adhesion Kinase Suppresses Breast Cancer Induced Bone Metastasis (2009)
  • 著者名/発表者名: Naito Kurio, Tsuyoshi Shimo, Munenori Takaoka, Tatsuo Okui, Norie Yoshioka, Nur Mohammad Monsur Hassan, Shinji Hatakeyama, Yoshio Naomoto, Akira Sasaki
  • 学会等名: The American Society for Bone and Mineral Research 31st Annual Meeting
  • 発表場所: Colorado, USA
  • 年月日: 20090911-15
• [図書] Squamous Cell Carcinoma : Role of connective tissue growth factor(CTGF/CCN2) in oral squamous cell carcinoma-induced bone destruction (2012)
  • 著者名/発表者名: Tsuyoshi Shimo, Akira Sasaki
  • 総ページ数: 175-194
  • 出版者: InTech