| 研究課題/領域番号 |
21F20712
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| 研究機関 | 沖縄科学技術大学院大学 |
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研究代表者 |
Kuhn Bernd 沖縄科学技術大学院大学, 光学ニューロイメージングユニット, 教授 (90599557)
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| 研究分担者 |
LI MELODY 沖縄科学技術大学院大学, 光学ニューロイメージングユニット, 外国人特別研究員
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| 研究期間 (年度) |
2021-09-28 – 2023-03-31
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| キーワード | Scn2a/Nav1.2 / neurological disorders / In vivo calcium imaging |
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| 研究実績の概要 |
1. Establish a novel mouse model that will be a valuable tool to study pathomechanisms underlying Scn2a neurological disorders
2. Study has been accepted for poster presentation at Neuro2022 conference
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
A novel Scn2a mouse model was created using antisense oligonucleotide technology. A battery of behavioural studies were performed and found the ASO treated mice mirror clinical features observed in patients with Scn2a neurological disorders. Simultaneous calcium imaging and electrocorticography (ECoG) was completed in a cohort of animals. Data analysis in progress.
Preliminary results suggest ASO treated mice have lowered power spectrum density power, specifically in the lower frequencies, when challenged with a pro-convulsant.
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| 今後の研究の推進方策 |
The plan is to complete calcium imaging analysis then segment both imaging and ECoG signal by running, resting and post-proconvulsant state. The data would reveal potential differences between ASO treated and control mice at a neural network level. This is the first study to explore in vivo neural network activities in a Scn2a mouse model and we expect outcomes to result in a publication.
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