| 研究課題/領域番号 |
21J10563
|
|---|
| 研究機関 | 東京大学 |
|---|
研究代表者 |
曹 娜 東京大学, 総合文化研究科, 特別研究員(DC2)
|
|---|
| 研究期間 (年度) |
2021-04-28 – 2023-03-31
|
| キーワード | Theta burst stimulation / Plasticity / Priming / NMES |
|---|
| 研究実績の概要 |
Two studies have been completed. The first study, which combine cortical and peripheral stimulations sequentially, has been published in the journal Experimental Brain Research. The second study, which tested the dose effect of the concurrent and associative electrical stimulation, its preliminary results has been presented in the conference “International Functional Electrical Stimulation Society (IFESS) RehabWeek”.
The project will lead to the development of new neuromodulation method that uses non-invasive brain stimulation and afferent recruitment.
|
| 現在までの達成度 (区分) |
現在までの達成度 (区分)
3: やや遅れている
理由
In the original schedule, the experimental plan consisted of two parts: Study 1: effects of combined TBS with NMES on excitability of corticospinal circuits in healthy subjects and study 2: effects of TBS and NMES associative stimulation for treatment of focal hand dystonia patients. However, due to covid-19 epidemic, it's hard to recruit the dystonia patients. Therefore, the study 2 for dystonia patients has been postoned.
|
| 今後の研究の推進方策 |
In this year, since it's hard to recruit hand dystonia patients, the proposal will be focus on the further development on the new paradigm for neuroplasticity improvement with sychronized cortical intermittent theta brust stimulation (iTBS)and peripheral electrical stimulation using neuromuscular electrical stimulation (NMES). The objective of this study is to compare the corticospinal excitability induced by cortical iTBS and concurrent or delayed NMES, as well as cortical iTBS and synchronized or asynchronized NMES. If it works, a new and more more effective protocal to further increase the neuroplasticity would be benefit for future clinical implications.
|
