| 研究実績の概要 |
The higher order mammalian genome is organized into euchromatin associated A, and heterochromatin associated B, compartments. In this project, I analyzed the mechanistic link between A/B compartments and early/late replication timing. By taking advantage of degron-based acute depletion of transcriptional machinery, I have found that transcriptional elongation functions as a molecular link to connect A/B compartments and early/late replication timing. Furthermore, by taking advantage of a conditional gene knockout strategy, I have been able to identify an epigenetic mechanism that functions directly downstream of transcriptional elongation to connect compartmentalization with replication timing.
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