| 研究課題/領域番号 |
21K14169
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| 研究機関 | 岡山大学 |
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研究代表者 |
WANG JIN 岡山大学, ヘルスシステム統合科学学域, 助教 (10870975)
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| 研究期間 (年度) |
2021-04-01 – 2024-03-31
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| キーワード | peptide / odorant binding protein / docking / organic receptors |
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| 研究実績の概要 |
This research focuses on developing peptide recognition elements for small volatile organic molecules detection, which are diseased-related compounds. Benzaldehyde and acetone binding peptides have been derived from the odorant binding protein. Through molecular docking and simulation, the binding pocket and residues are determined. The amino acids SER and GLN played an important role in interaction with
benzaldehyde by forming hydrogen bond and THR with acetone.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
The amino acids sequence for small volatile organic compounds benzaldehyde and acetone has been obtaied through the powerful computational visualization from the most sensitive mosquito odorant binding protein (mOBP). The approach addressed promising strategy for further development of recognition elements for odor sensing. Initial investigation on computation of organic receptors for small molecules has been published in the journal of the electrochemistry society. Based on the original research plan, the results on the peptide will be summarized and presented on the conference.
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| 今後の研究の推進方策 |
After obtain the binding peptide, the peptide modified plasmonic sensor and quartz crystal
microbalance sensor will be performed for further evaluation of the binding affinity of designed peptide receptors. Meanwhile, the selectiviy of the peptides will be also investigated.
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| 次年度使用額が生じた理由 |
fabricate the sensor chip and consumption of related reagents, and meeting and paper fee.
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