| 研究実績の概要 |
In this year, we further conducted experiments to determine if a carnosine regulator, vitamin B6, has any effects on muscle regeneration. We found that vitamin B6 deficient (1 mg PN* HCl/kg diet) and supplemented (35 mg/kg diet) diets significantly decreased carnosine levels in skeletal muscles, as compared to vitamin B6 recommended level diet (7 mg/kg diet). Next, we found that vitamin B6 deficiency (1 mg/kg diet) impaired muscle regeneration, reflecting by lower regenerating muscle mass and smaller myofiber size than the recommended vitamin B6 level (7 mg/kg diet) diet. Surprisingly, a high dose of vitamin B6 (35 mg/kg diet) also worsened muscle regeneration, which was against our expectation. Taken together the results suggest that the proper intake levels of vitamin B6 and higher levels of muscle carnosine are important to ensure the proper process of muscle regeneration. PN:Pyridoxine Hydrochloride
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