| 研究実績の概要 |
Chemotherapy induced bone marrow stress and subsequent Hematopoietic stem cells (HSCs) regeneration has been extensively studied, and yet the precise mechanism regulating the HSC divisional fate is not completely resolved. Since the accessibility-changed regions between self-renewal and differentiation divisions significantly enriched Runx-binding motifs during bone marrow regeneration, my proposed study will look into the Runx-based epigenetic modification of HSCs during the course of bone marrow regeneration. In this year, I compared chromatin accessibility of Runx enhancers between self-renewal and differentiation types of HSCs, and identify candidate of Runx enhancer regions that affect its expression.
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