| 研究実績の概要 |
Hypermucoviscosity (HMV) is a phenotype commonly associated with hypervirulence of Klebsiella pneumoniae (Kp), which is usually regulated by rmpA or rmpA2 genes. Our analysis showed that the low HMV level is usually related to rmpA/rmpA2, while the high HMV level is not. Strains carrying rmpA/rmpA2 are likely to express HMV at 37°C, whereas those negative for these genes are likely to express HMV at room temperature.
Kp also produces several kinds of bacteriocins that have antimicrobial effects against other species. We found that 32.8% of isolates carried at least one bacteriocin type. Microcin E492 was the most prevalent type (14.4%) and had a wide spectrum of activity. Cloacin-like bacteriocin was detected in 7.2% of strains and exhibited inhibitory effect against mainly Klebsiella spp.
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