研究課題/領域番号 |
21K17268
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研究機関 | 浜松医科大学 |
研究代表者 |
Rahman Md.Shafiur 浜松医科大学, 子どものこころの発達研究センター, 特任講師 (60874360)
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研究期間 (年度) |
2021-04-01 – 2024-03-31
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キーワード | Neurodevelopment / ADHD / ASD / body mass index / genetic risk / autism |
研究実績の概要 |
This study aimed to investigate whether the interaction between genetic risk for neurodevelopmental disorders (NDDs) and changes in body mass index (BMI) during infancy (birth to 24 months) affects the severity of attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorders (ASD) traits in Japanese children. The study population comprises 1,258 children from the Hamamatsu Birth Cohort for Mother and Child with available follow-up information. The main exposures of interest are (1) changes in BMI between birth and 24 months, and (2) genetic risk for NDDs. The outcomes are: symptoms of ADHD and ASD measured at 6, 8 and 12 years. Data analysis was completed for outcomes assessed at 6 years of age. Also, we conducted follow-up interviews among 422 children aged 12 years.
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現在までの達成度 (区分) |
現在までの達成度 (区分)
1: 当初の計画以上に進展している
理由
Our systematic review on early BMI changes and neurodevelopmental disorders, conducted in the first year, found no similar studies among Japanese population. We also calculated the polygenic risk scores for autism spectrum disorder and attention deficit hyperactivity disorders by the first academic year.
Data management for follow-up interviews conducted when the children were 6 and 8 years old has been completed. Additionally, the initial analysis of the follow-up data collected when the children were 6 years old has been completed. Moreover, we already conducted follow-up interviews with 422 children who have now turned 12 years old, and assessed their ADHD and ASD symptoms using the Conners Rating Scale for ADHD and the Social Responsiveness Scale, respectively.
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今後の研究の推進方策 |
Our research project is still ongoing, and by the end of this academic year, we plan to conduct follow-up interviews with an additional 300 children who are now 12 years old. Furthermore, we intend to prepare two manuscripts based on our findings and submit them to international journals.
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次年度使用額が生じた理由 |
Covid -19に関連する様々な制限やその影響のため、当初予想していた数の面接を行う事ができませんでした。そのため来年度は面接数を増やす予定であり、そのために研究助手を増員する必要があると考えており、この未使用額を来年度に含める予定です。 加えて私は今年度2つの論文出版を考えており、その出版費用を支払う予定、さらに国際学会にて研究成果を発表をする予定であり、最終年度の今年はお金を必要と考えたため。
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