Ligand-free hepatocyte-targeting of nanomedicines by selective stealth coating of liver reticuloendothelial system scavenger cells

2023 年度 実績報告書

• 研究課題/領域番号: 21K18062
• 研究機関: 公益財団法人川崎市産業振興財団(ナノ医療イノベーションセンター)
• 研究代表者: ディリサラ アンジャネユル 公益財団法人川崎市産業振興財団(ナノ医療イノベーションセンター), ナノ医療イノベーションセンター, 主任研究員 (70794353)
• 研究期間 (年度): 2021-04-01 – 2024-03-31
• キーワード: Liver sinusoidal coating

研究実績の概要

Our transient liver sinusoidal stealth coating strategy successfully increased the protein expression efficiency in the liver from mRNA-adsorbed liposomes than the level observed without two-arm-PEG-OligoLys preinjection. Intriguingly, the same sinusoidal stealth coating strategy decreased the liver expression of mRNA-loaded lipid nanoparticles and relocated them from liver to spleen. This discrepancy in the gene expression efficiency may be attributed to size and charge of nanoparticles.

研究成果

• [雑誌論文] Nanoarchitectonics of mesoporous carbon spheres by tuning the weight ratio of PEG-PCL block copolymer as template and phenol as carbon source towards supercapacitor applications (2024)
  • 著者名/発表者名: Murugan M.、Dineshkumar G.、Dirisala Anjaneyulu、Jegadeesan P.、Ganesan M.、Amirthapandian S.、Sivanantham M.
  • 雑誌名: Journal of Materials Science: Materials in Electronics 巻: 35 ページ: 206
  • DOI: 10.1007/s10854-023-11872-y
  • 査読あり / 国際共著
• [雑誌論文] Deciphering the Structural and Functional Properties of ABC-F ATPases (2023)
  • 著者名/発表者名: Saha Chiranjeet, Saha Sujata, Chakraborty Asmita, Dirisala Anjaneyulu, Maity Amit Ranjan, Bhowmik Priyanka, Sikder Kunal, Chakraborti Soumyananda, Basu Arnab
  • 雑誌名: Infectious Diseases Diagnosis & Treatment 巻: 7 ページ: 2577
  • DOI: 10.29011/2577-1515.100225
  • 査読あり / オープンアクセス / 国際共著
• [雑誌論文] Curcumin and Colistin are Synergistic in Inhibiting the Growth and Biofilm Formation of Pseudomonas aeruginosa Isolated from Environmental Sample (2023)
  • 著者名/発表者名: Barkha Modi, Sabarnee Bahadur, Priyanka Bhowmik, Soumyananda Chakraborti, Dirisala Anjaneyulu, Ali Hossain Khan, Abhrajyoti Ghosh, Sangita Mondal, Amit Ranjan Maity, Arnab Basu
  • 雑誌名: Infectious Diseases Diagnosis & Treatment 巻: 7 ページ: 2577
  • DOI: 10.29011/2577-1515.100218
  • 査読あり / オープンアクセス / 国際共著
• [雑誌論文] Overcoming the barriers of nuclear-targeted drug delivery using nanomedicine-based strategies for enhanced anticancer therapy (2023)
  • 著者名/発表者名: Roy Sayoni Maitra、Garg Vrinda、Sivaraman Sushmitha Pedugu、Barman Sourav、Ghosh Chitrita、Bag Pousali、Mohanasundaram Palanivelmurugan、Maji Partha Sona、Basu Arnab、Dirisala Anjaneyulu、Ghosh Surya K.、Maity Amit Ranjan
  • 雑誌名: Journal of Drug Delivery Science and Technology 巻: 83 ページ: 104408～104408
  • DOI: 10.1016/j.jddst.2023.104408
  • 査読あり / 国際共著
• [雑誌論文] Stealth and pseudo-stealth nanocarriers (2023)
  • 著者名/発表者名: Wen Panyue、Ke Wendong、Dirisala Anjaneyulu、Toh Kazuko、Tanaka Masaru、Li Junjie
  • 雑誌名: Advanced Drug Delivery Reviews 巻: 198 ページ: 114895～114895
  • DOI: 10.1016/j.addr.2023.114895
  • 査読あり / 国際共著
• [雑誌論文] pH-responsive polyzwitterion covered nanocarriers for DNA delivery (2023)
  • 著者名/発表者名: Shen Xin、Dirisala Anjaneyulu、Toyoda Masahiro、Xiao Yao、Guo Haochen、Honda Yuto、Nomoto Takahiro、Takemoto Hiroyasu、Miura Yutaka、Nishiyama Nobuhiro
  • 雑誌名: Journal of Controlled Release 巻: 360 ページ: 928～939
  • DOI: 10.1016/j.jconrel.2023.07.038
  • 査読あり / 国際共著
• [雑誌論文] Editorial: Delivery systems in biologics-based therapeutics (2023)
  • 著者名/発表者名: Dirisala Anjaneyulu、Li Junjie、Gonzalez-Carter Daniel、Wang Zheng
  • 雑誌名: Frontiers in Bioengineering and Biotechnology 巻: 11 ページ: 1274210
  • DOI: 10.3389/fbioe.2023.1274210
  • 査読あり / オープンアクセス / 国際共著
• [雑誌論文] Oligosarcosine Conjugation of Arginine-Rich Peptides Improves the Intracellular Delivery of Peptide/pDNA Complexes (2023)
  • 著者名/発表者名: Yokoo Hidetomo、Dirisala Anjaneyulu、Uchida Satoshi、Oba Makoto
  • 雑誌名: ACS Biomaterials Science & Engineering 巻: 10 ページ: 890～896
  • DOI: 10.1021/acsbiomaterials.3c01542
  • 査読あり / 国際共著
• [雑誌論文] Acidic pH-Triggered Release of Doxorubicin from Ligand-Decorated Polymeric Micelles Potentiates Efficacy against Cancer Cells (2023)
  • 著者名/発表者名: Maitra Roy Sayoni、Barman Sourav、Kishore Purvi、Chatterjee Bhaskar、Bag Pousali、Ghatak Tapas、Basu Arnab、Ghosh Surya K.、Dirisala Anjaneyulu、Sarkar Ankan Kumar、Khan Ali Hossain、Ghosh Dastidar Somasish、Maity Amit Ranjan
  • 雑誌名: ACS Applied Nano Materials 巻: 6 ページ: 18988～18998
  • DOI: 10.1021/acsanm.3c03481
  • 査読あり / 国際共著
• [学会発表] Transient stealth coating of liver scavenger sinusoidal wall enables retargeting of nanomedicines (2023)
  • 著者名/発表者名: Dirisala Anjaneyulu、Uchida Satoshi、Kataoka Kazunori
  • 学会等名: 29th International conference on processing and fabrication of advanced materials
  • 国際学会
• [学会発表] Selective and transient stealth coating of liver scavenger wall enables retargeting of nanomedicines (2023)
  • 著者名/発表者名: Dirisala Anjaneyulu、Uchida Satoshi、Kataoka Kazunori
  • 学会等名: 14th ISAJ annual symposium on integrated science for a sustainable Society
  • 招待講演
• [産業財産権] 脂質ナノ小胞を脾臓に標的化する方法およびそのための組成物 (2023)
  • 発明者名: 内田智士,Anjaneyulu Dirisala,片岡 一則
  • 権利者名: 内田智士,Anjaneyulu Dirisala,片岡 一則
  • 産業財産権種類: 特許
  • 産業財産権番号: 1