The combined application of mineral trioxide aggregate containing phosphorylated pullulan and colloidal platinum nanoparticles to control inflammation and facilitate dental pulp regeneration

2022 年度 実績報告書

• 研究課題/領域番号: 21K21028
• 研究機関: 北海道大学
• 研究代表者: ISLAM RAFIQUL 北海道大学, 歯学研究院, 助教 (00906414)
• 研究期間 (年度): 2021-08-30 – 2023-03-31
• キーワード: Direct pulp capping / Platinum Nanoparticles / Phosphorylated pullulan / MTA / Dental pulp

研究実績の概要

We have evaluated the combined application of mineral trioxide aggregate (MTA) and phosphorylated pullulan (PPL) for use in direct pulp capping (DPC). Our findings showed that the novel MTAPPL exhibits comparable inflammatory pulpal responses and mineralized tissue formation inducibility to conventional MTA, suggesting its potential for use in DPC. In addition, we have investigated the healing response of colloidal platinum nanoparticles (CPNs) in exposed dental pulp. Our results demonstrated a favorable healing response in the exposed dental pulp, with the presence of CD34 endothelial cells indicating angiogenesis in the dental pulp.
Overall, our findings suggest that the MTAPPL and CPNs have promising potential for use in dental pulp therapy.

研究成果

• [雑誌論文] Direct pulp capping procedures ? Evidence and practice (2023)
  • 著者名/発表者名: Islam Rafiqul、Islam Md Refat Readul、Tanaka Toru、Alam Mohammad Khursheed、Ahmed Hany Mohamed Aly、Sano Hidehiko
  • 雑誌名: Japanese Dental Science Review 巻: 59 ページ: 48～61
  • DOI: 10.1016/j.jdsr.2023.02.002
  • 査読あり / オープンアクセス / 国際共著
• [雑誌論文] Effect of sodium hypochlorite on bonding performance of universal adhesives to pulp chamber dentin (2022)
  • 著者名/発表者名: Yuan Yuan、Intajak Papichaya、Islam Rafiqul、Ting Shihchun、Matsumoto Mariko、Hoshika Shuhei、Sano Hidehiko
  • 雑誌名: Journal of Dental Sciences 巻: - ページ: -
  • DOI: 10.1016/j.jds.2022.11.007
  • 査読あり / オープンアクセス / 国際共著
• [雑誌論文] Influence of Novel Experimental Light-Cured Resin Cement on Microtensile Bond Strength (2022)
  • 著者名/発表者名: Kawamura Midori、Toida Yu、Hoshika Shuhei、Islam Md Refat Readul、Li Yitong、Yao Ye、Liu Yunqing、Islam Rafiqul、Sato Takaaki、Shimada Yasushi、Sano Hidehiko
  • 雑誌名: Polymers 巻: 14 ページ: 4075～4075
  • DOI: 10.3390/polym14194075
  • 査読あり / オープンアクセス / 国際共著
• [雑誌論文] Teledentistry as an Effective Tool for the Communication Improvement between Dentists and Patients: An Overview (2022)
  • 著者名/発表者名: Islam Md Refat Readul、Islam Rafiqul、Ferdous Sultana、Watanabe Chiharu、Yamauti Monica、Alam Mohammad Khursheed、Sano Hidehiko
  • 雑誌名: Healthcare 巻: 10 ページ: 1586～1586
  • DOI: 10.3390/healthcare10081586
  • 査読あり / オープンアクセス / 国際共著
• [雑誌論文] Evaluation of Color and Spectral Behavior of a Novel Flowable Resin Composite after Water Aging: An In Vitro Study (2022)
  • 著者名/発表者名: Chen Fei、Wu Di、Islam Rafiqul、Toida Yu、Kawamoto Chiharu、Yamauti Monica、Sano Hidehiko
  • 雑誌名: Materials 巻: 15 ページ: 4102～4102
  • DOI: 10.3390/ma15124102
  • 査読あり / オープンアクセス / 国際共著
• [学会発表] Colloidal Platinum Nanoparticles Enhance the Healing Potential of Dental Pulp. (2022)
  • 著者名/発表者名: Islam Rafiqul
  • 学会等名: 2022 IADR/APR General Session & Exhibition, China.
  • 国際学会