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2012 年度 研究成果報告書

高脂肪・高カロリー食による泌尿器癌の進展の分子機構の解明と治療標的分子の同定

研究課題

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研究課題/領域番号 22390302
研究種目

基盤研究(B)

配分区分補助金
応募区分一般
研究分野 泌尿器科学
研究機関秋田大学

研究代表者

羽渕 友則  秋田大学, 大学院・医学系研究科, 教授 (00293861)

研究分担者 大山 力  弘前大学, 大学院・医学系研究科, 教授 (80282135)
土谷 順彦  秋田大学, 大学院・医学系研究科, 准教授 (70282176)
湯浅 健  財団法人癌研究会, 附属病院・化学療法科 (00314162)
南條 博  秋田大学, 医学部, 教授 (70250892)
堀川 洋平  秋田大学, 医学部, 講師 (40361232)
研究期間 (年度) 2010 – 2012
キーワード肥満 / 高脂肪食 / 前立腺癌 / 腎細胞癌 / IGF-1
研究概要

近年の泌尿器癌(特に前立腺癌や腎細胞癌)の増加は著しい。原因として食生活の変化、特に高カロリー・脂肪食の影響が示唆されている。本研究では、実験動物、細胞生物学、分子疫学、臨床検体を用いた多方面からのアプローチにより、高カロリー・高脂肪食による泌尿器癌進展の分子機構を腫瘍微小環境にも注目しながら解明、標的分子を同定し、治療や予防への可能性を検討した(Prostate 2008, Carcinogenesis 2011, Nat Genet 2011, Prostate 2012, Nat Genet 2012, BMC Cancer 2013)。

  • 研究成果

    (33件)

すべて 2013 2012 2011 2010 2009 2008 その他

すべて 雑誌論文 (20件) 学会発表 (8件) 図書 (2件) 備考 (1件) 産業財産権 (2件) (うち外国 1件)

  • [雑誌論文] Insulin-like growth factor-1 genotypes and haplotypes influence the survival of prostate cancer patients with bone metastasis at initial diagnosis2013

    • 著者名/発表者名
      Tsuchiya N, Narita S, Inoue T, Saito M, Numakura K, Huang M, Hatakeyama S, Satoh S, Saito S, Ohyama C, Arai Y, Ogawa O, Habuchi T.
    • 雑誌名

      BMC Cancer

      巻: 13(1) ページ: 150

  • [雑誌論文] The UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology; The UK ProtecT Study Collaborators; The Australian Prostate Cancer Bioresource; The PRACTICAL Consortium, Chanock S, Gronberg H, Haiman CA, Kraft P, Easton DF, Eeles RA. A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease2013

    • 著者名/発表者名
      Amin Al Olama A, Kote-Jarai Z, Schumacher FR, Wiklund F, Berndt SI, Benlloch S, Giles GG, Severi G, Neal DE, Hamdy FC, Donovan JL, Hunter DJ, Henderson BE, Thun MJ, Gaziano M, Giovannucci EL, Siddiq A, Travis RC, Cox DG, Canzian F, Riboli E, Key TJ, Andriole G, Albanes D, Hayes RB, Schleutker J, Auvinen A, Tammela TL, Weischer M, Stanford JL, Ostrander EA, Cybulski C, Lubinski J, Thibodeau SN, Schaid DJ, Sorensen KD, Batra J, Clements JA, Chambers S, Aitken J, Gardiner RA, Maier C, Vogel W, Dork T, Brenner H, Habuchi T, Ingles S, John EM, Dickinson JL, Cannon-Albright L, Teixeira MR, Kaneva R, Zhang HW, Lu YJ, Park JY, Cooney KA, Muir KR, Leongamornlert DA, Saunders E, Tymrakiewicz M, Mahmud N, Guy M, Govindasami K, O'Brien LT, Wilkinson RA, Hall AL, Sawyer EJ, Dadaev T, Morrison J, Dearnaley DP, Horwich A, Huddart RA, Khoo VS, Parker CC, Van As N, Woodhouse CJ, Thompson A, Dudderidge T, Ogden C, Cooper CS, Lophatonanon A, Southey MC, Hopper JL, English D, Virtamo J, Le Marchand L, Campa D, Kaaks R, Lindstrom S, Diver WR, Gapstur S, Yeager M, Cox A, Stern MC, Corral R, Aly M, Isaacs W, Adolfsson J, Xu J, Zheng SL, Wahlfors T, Taari K, Kujala P, Klarskov P, Nordestgaard BG, Roder MA, Frikke-Schmidt R, Bojesen SE, Fitzgerald LM, Kolb S, Kwon EM, Karyadi DM, Orntoft TF, Borre M, Rinckleb A, Luedeke M, Herkommer K, Meyer A, Serth J, Marthick JR, Patterson B, Wokolorczyk D, Spurdle A, Lose F, McDonnell SK, Joshi AD, Shahabi A, Pinto P, Santos J, Ray A, Sellers TA, Lin HY, Stephenson RA, Teerlink C, Muller H, Rothenbacher D, Tsuchiya N, Narita S, Cao GW, Slavov C, Mitev V
    • 雑誌名

      Hum Mol Genet

      巻: 22(2) ページ: 408-415

  • [雑誌論文] Reproducibility, performance, and clinical utility of a genetic risk prediction model for prostate cancer in Japanese2012

    • 著者名/発表者名
      Akamatsu S, Takahashi A, Takata R, Kubo M, Inoue T, Morizono T, Tsunoda T, Kamatani N, Haiman CA, Wan P, Chen GK, Le Marchand L, Kolonel LN, Henderson BE, Fujioka T, Habuchi T, Nakamura Y, Ogawa O, Nakagawa H.
    • 雑誌名

      PLoS One

      巻: 7(10) ページ: e46454

  • [雑誌論文] A high-fat diet enhances proliferation of prostate cancer cells and activates MCP-1/CCR2 signaling2012

    • 著者名/発表者名
      Huang M, Narita S, Numakura K, Tsuruta H, Saito M, Inoue T, Horikawa Y, Tsuchiya N, Habuchi T.
    • 雑誌名

      Prostate

      巻: 72(16) ページ: 1779-88

  • [雑誌論文] Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese2012

    • 著者名/発表者名
      Akamatsu S , Takata R, Haiman CA, Takahashi A, Inoue T, Kubo M, Furihata M, Kamatani N, Inazawa J, Chen GK, Le Marchand L, Kolonel LN, Katoh T, Yamano Y, Yamakado M, Takahashi H, Yamada H, Egawa S, Fujioka T, Henderson BE, Habuchi T, Ogawa O, Nakamura Y, and Nakagawa H.
    • 雑誌名

      Nat Genet

      巻: 44(4) ページ: 426-9

  • [雑誌論文] Genomic profiling of renal cell carcinoma in patients with end-stage renal disease2012

    • 著者名/発表者名
      Inoue T, Matsuura K, Yoshimoto T, Nguyen LT, Tsukamoto Y, Nakada C, Hijiya N, Narimatsu T, Nomura T, Sato F, Nagashima Y, Kashima K, Hatakeyama S, Ohyama C, Numakura K, Habuchi T, Nakagawa M, Seto M, Mimata H, Moriyama M.
    • 雑誌名

      Cancer Sci

      巻: 103(3) ページ: 569-76

  • [雑誌論文] Outcome, clinical prognostic factors and genetic predictors of adverse reactions of intermittent combination chemotherapy with docetaxel estramustine phosphate and carboplatin for castration-resistant prostate cancer2012

    • 著者名/発表者名
      Narita S, Tsuchiya N, Yuasa T, Maita S, Obara T, Numakura K, Tsuruta H, Saito M, Inoue T, Horikawa Y, Satoh S, Habuchi T.
    • 雑誌名

      Int J Clin Oncol

      巻: 17(3) ページ: 204-11

  • [雑誌論文] Antitumor effect of sunitinib against skeletal metastatic renal cell carcinoma through inhibition of osteoclast function2012

    • 著者名/発表者名
      Maita S, Yuasa T, Tsuchiya N, Mitobe Y, Narita S, Horikawa Y, Hatake K, Fukui I, Kimura S, Maekawa T, Habuchi T.
    • 雑誌名

      Int J Cancer

      巻: 130(3) ページ: 677-84

  • [雑誌論文] Overexpression of Fn14 promotes androgen-independent prostate cancer progression through MMP-9 and correlates with poor treatment outcome2011

    • 著者名/発表者名
      Huang M, Narita S, Tsuchiya N, Ma Z, Numakura K, Obara T, Tsuruta H, Saito M, Inoue T, Horikawa Y, Satoh S, Habuchi T.
    • 雑誌名

      Carcinogenesis

      巻: 32(11) ページ: 1589-96

  • [雑誌論文] Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study2011

    • 著者名/発表者名
      Kote-Jarai Z, Olama AA, Giles GG, Severi G, Schleutker J, Weischer M, Campa D, Riboli E, Key T, Gronberg H, Hunter DJ, Kraft P, Thun MJ, Ingles S, Chanock S, Albanes D, Hayes RB, Neal DE, Hamdy FC, Donovan JL, Pharoah P, Schumacher F, Henderson BE, Stanford JL, Ostrander EA, Sorensen KD, Dork T, Andriole G, Dickinson JL, Cybulski C, Lubinski J, Spurdle A, Clements JA, Chambers S, Aitken J, Gardiner RA, Thibodeau SN, Schaid D, John EM, Maier C, Vogel W, Cooney KA, Park JY, Cannon-Albright L, Brenner H, Habuchi T, Zhang HW, Lu YJ, Kaneva R, Muir K, Benlloch S, Leongamornlert DA, Saunders EJ, Tymrakiewicz M, Mahmud N, Guy M, O'Brien LT, Wilkinson RA, Hall AL, Sawyer EJ, Dadaev T, Morrison J, Dearnaley DP, Horwich A, Huddart RA, Khoo VS, Parker CC, Van As N, Woodhouse CJ, Thompson A, Christmas T, Ogden C, Cooper CS, Lophatonanon A, Southey MC, Hopper JL, English DR, Wahlfors T, Tammela TL, Klarskov P, Nordestgaard BG, Roder MA, Tybjarg-Hansen A, Bojesen SE, Travis R, Canzian F, Kaaks R, Wiklund F, Aly M, Lindstrom S, Diver WR, Gapstur S, Stern MC, Corral R, Virtamo J, Cox A, Haiman CA, Le Marchand L, Fitzgerald L, Kolb S, Kwon EM, Karyadi DM, Orntoft TF, Borre M, Meyer A, Serth J, Yeager M, Berndt SI, Marthick JR, Patterson B, Wokolorczyk D, Batra J, Lose F, McDonnell SK, Joshi AD, Shahabi A, Rinckleb AE, Ray A, Sellers TA, Lin HY, Stephenson RA, Farnham J, Muller H, Rothenbacher D, Tsuchiya N, Narita S, Cao GW, Slavov C, Mitev V; The UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology; The UK ProtecT Study Collaborators, The Australian Prostate Cancer BioResource; The PRACTICAL Consortium, Easton DF, Eeles RA.
    • 雑誌名

      Nat Genet

      巻: 43(8) ページ: 785-91

  • [雑誌論文] A Novel Strategy for Evasion of NK Cell Immunity by Tumours Expressing Core2 O-glycans2011

    • 著者名/発表者名
      Tsuboi S, Sutoh M, Hatakeyama S, Hiraoka N, Habuchi T, Horikawa Y, Hashimoto Y, Yoneyama T, Mori K, Koie T, Nakamura T, Saitoh H, Yamaya K, Funyu T, Fukuda M, Ohyama C.
    • 雑誌名

      EMBO J.

      巻: 30(15) ページ: 3173-85

  • [雑誌論文] Two survivin polymorphisms are cooperatively associated with bladder cancer susceptibility2011

    • 著者名/発表者名
      Kawata N, Tsuchiya N, Horikawa Y, Inoue T, Tsuruta H, Maita S, Sato S, Mitobe Y, Narita S, Habuchi T.
    • 雑誌名

      Int J Cancer

      巻: 129(8) ページ: 1872-80

  • [雑誌論文] Clinical significance of polymorphism and expression of chromogranin a and endothelin-1 in prostate cancer2010

    • 著者名/発表者名
      Ma Z, Tsuchiya N, Yuasa T, Huang M, Obara T, Narita S, Horikawa Y, Tsuruta H, Saito M, Satoh S, Ogawa O, Habuchi T.
    • 雑誌名

      J Urol

      巻: 184(3) ページ: 1182-8

  • [雑誌論文] Clinical significance of a single nucleotide polymorphism and allelic imbalance of matrix metalloproteinase-1 promoter region in prostate cancer2009

    • 著者名/発表者名
      Tsuchiya N, Narita S, Kumazawa T, Inoue T, Ma Z, Tsuruta H, Saito M, Horikawa Y, Yuasa T, Satoh S, Ogawa O, Habuchi T.
    • 雑誌名

      Oncol Rep

      巻: 22(3) ページ: 493-9

  • [雑誌論文] The novel tumor-suppressor Mel-18 in prostate cancer: Its functional polymorphism, expression, and clinical significance2009

    • 著者名/発表者名
      Wang W, Yuasa T, Tsuchiya N, Ma Z, Maita S, Narita S, Kumazawa T, Inoue T, Tsuruta H, Horikawa Y, Saito M, Hu W, Ogawa O, Habuchi T
    • 雑誌名

      Int J Cancer

      巻: 125(12) ページ: 2836-43

  • [雑誌論文] Intravesical administration of gammadelta T cells successfully prevents the growth of bladder cancer in the murine model2009

    • 著者名/発表者名
      Yuasa T, Sato K, Ashihara E, Takeuchi M, Maita S, Tsuchiya N, Habuchi T, Maekawa T, Kimura S
    • 雑誌名

      Cancer Immunol Immunother

      巻: 58(4) ページ: 493-502

  • [雑誌論文] Polymorphisms of fibroblast growth factor receptor 4 have association with the development of prostate cancer and benign prostatic hyperplasia and the progression of prostate cancer in a Japanese population2008

    • 著者名/発表者名
      Ma Z, Tsuchiya N, Yuasa T, Inoue T, Kumazawa T, Narita S, Horikawa Y, Tsuruta H, Obara T, Saito M, Satoh S, Ogawa O, Habuchi T.
    • 雑誌名

      Int J Cancer

      巻: 123(11) ページ: 2574-2579

  • [雑誌論文] Bone mineral density in Japanese prostate cancer patients under androgen-deprivation therapy2008

    • 著者名/発表者名
      Wang W, Yuasa T, Tsuchiya N, Maita S, Kumazawa T, Inoue T, Saito M, Ma Z, Obara T, Tsuruta H, Satoh S, Habuchi T.
    • 雑誌名

      Endocr Relat Cancer

      巻: 15(4) ページ: 943-52

  • [雑誌論文] Association of genetic polymorphisms at 8q24 with the risk of prostate cancer in a Japanese population2008

    • 著者名/発表者名
      Terada N, Tsuchiya N, Ma Z, Shimizu Y, Kobayashi T, Nakamura E, Kamoto T, Habuchi T, Ogawa O.
    • 雑誌名

      Prostate

      巻: 68(15) ページ: 1689-95

  • [雑誌論文] A genetic polymorphism of the osteoprotegerin gene is associated with an increased risk of advanced prostate cancer2008

    • 著者名/発表者名
      Narita N, Yuasa T, Tsuchiya N, Kumazawa T, Narita S, Inoue T, Ma Z, Saito M, Horikawa Y, Satoh S, Ogawa O, Habuchi T
    • 雑誌名

      BMC Cancer

      巻: 8 ページ: 224

  • [学会発表] Functional mononucleotide repeats in the HGF promoter are associated with bladder cancer progression2012

    • 著者名/発表者名
      Chiba, S., Horaikawa, Y., Maita, S., Numakura, K., Obara, T., Inoue, T., Narita, S., Tsuchiya, N., Satoh, S.and Habuchi, T.
    • 学会等名
      The 107th annual meeting of the American Urological Association
    • 発表場所
      Atlanta, USA
    • 年月日
      20120500
  • [学会発表] Functional genetic polymorphisms in the CYP19 gene decrease the risk of prostate cancer and alter the response to androgen deprovation therapy2012

    • 著者名/発表者名
      Kanda, S., Tsuchiya, N., Kou, M., Chiba, S., Satoyoshi, K., Maita, S., Numakura, K., Obara, T., Inoue, T., Narita, S., Horikawa, Y., Satoh, S.and Habuchi, N.
    • 学会等名
      The 107th annual meeting of the American Urological Association
    • 発表場所
      Atlanta, USA
    • 年月日
      20120500
  • [学会発表] Stimulation of macrophage inhibitory cytokine-1 by palmitic acid activates prostate cancer cell invasiveness2012

    • 著者名/発表者名
      Huang, M., Narita, S., Maita, S., Numakura, K., Obara, T., Inoue, T., Horikawa, Y., Satoh, S.and Habuchi, T.
    • 学会等名
      The 107th annual meeting of the American Urological Association
    • 発表場所
      Atlanta, USA
    • 年月日
      20120500
  • [学会発表] Prediction of Survival in Metastatic Prostate Cancer Patients by SNP Array Analysis of Cancer-Associated Genes2011

    • 著者名/発表者名
      Tsuchiya, N., Matsui, S., Narita, S., Inoue, T., Numakura, K., Horikawa, Y., Hatakeyama, S., Ogawa, O., Arai, Y., Saito, S., Ohyama, C., Habuchi, T.
    • 学会等名
      The 106th Annunal Meeting of the American Urological Association
    • 発表場所
      Washisnton DC, USA
    • 年月日
      20110500
  • [学会発表] Prostate cancer progression under high fat diet is enhanced by the MCP-1/CCR2 signaling2011

    • 著者名/発表者名
      Huang, M., Narita, S., Numakura, K., Tsuruta, H., Saito, M., Inoue, T., Horikawa, Y., Tsuchiya, N., Habuchi, T.
    • 学会等名
      The 106th Annunal Meeting of the American Urological Association
    • 発表場所
      Washisnton DC, USA
    • 年月日
      20110500
  • [学会発表] GENETIC POLYMORPHISM INFLUENCES INDIVIDUAL VARIATIONS IN SERUM TESTOSTERONE LEVELS IN PROSTATE CANCER PATIENTS TREATED WITH ANDROGEN DEPRIVATION THERAPY2010

    • 著者名/発表者名
      Narita, S., Numakura, K., Obara, T., Tsuruta, H., Saito, M., Horikawa, Y., Tsuchiya, N., Habuchi, T.
    • 学会等名
      The 105th Annual Meeting of the American Urological Association, May
    • 発表場所
      San Francisco, USA
    • 年月日
      20100500
  • [学会発表] INSULIN-LIKE GROWTH FACTOR-I (IGF-I) POLYMORPHISMS PREDICT THE SURVIVAL OF PROSTATE CANCER PATIENTS WITH BONE METASTASIS AT INITIAL PRESENTATION2010

    • 著者名/発表者名
      Tsuchiya, N., Narita, S., Ma, Z., Horikawa, Y., Tsuruta, H., Numakura, K., Saito, M., Satoh, S., Inoue, T., Ogawa, O., Habuchi. T.
    • 学会等名
      The 105th Annual Meeting of the American Urological Association
    • 発表場所
      San Francisco, USA
    • 年月日
      20100500
  • [学会発表] TWEAK-FN14 SIGNALING REGULATES ANDROGEN-INDEPENDENT PROSTATE CANCER CELL INVASIVENESS AND CORRELATES WITH POOR PATIENT OUTCOME2010

    • 著者名/発表者名
      Mingguo, H., Narita, S., Ma, Z., Numakura, K., Obara, T., Tsuruta, H., Saito, M., Horikawa, Y., Tsuchiya, N., Habuchi, T.
    • 学会等名
      The 105th Annual Meeting of the American Urological Association
    • 発表場所
      San Francisco, USA
    • 年月日
      20100500
  • [図書] Humana Press, Springer US, New York2011

    • 著者名/発表者名
      Habuchi, T.
    • 総ページ数
      139-163
    • 出版者
      Prognostic Markers for Bladder Cancer. In: "Bladder Tumors: Molecular Aspects and Clinical Management
  • [図書] Inc. New York2011

    • 著者名/発表者名
      Habuchi, T. and Kakizoe, T
    • 総ページ数
      295-315 (Chapter 16)
    • 出版者
      Clonality of Multifocal Urothelial Cancer and Field Cancerization. In: Field Cancerization- Basic science and clinical applications- , Nova Science Publishers
  • [備考]

    • URL

      http://www.med.akita-u.ac.jp/~hinyoki/

  • [産業財産権] 前立腺癌の予後の予測方法2013

    • 発明者名
      羽渕友則、 土谷順彦
    • 権利者名
      国立大学法人秋田大学
    • 産業財産権番号
      特許2011-186698
    • 出願年月日
      2013-03-14
  • [産業財産権] 前立腺癌の予後の予測方法2012

    • 発明者名
      羽渕友則、 土谷順彦
    • 権利者名
      国立大学法人秋田大学
    • 産業財産権番号
      特許PF000464-PCT
    • 出願年月日
      20120000
    • 外国

URL: 

公開日: 2014-08-29  

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