放射線被曝影響解析に向けた線量付与の統計的モデルの構築

2012 年度 研究成果報告書

• 研究課題/領域番号: 22510055
• 研究種目: 基盤研究(C)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 放射線・化学物質影響科学
• 研究機関: 北海道大学
• 研究代表者: 伊達 広行 北海道大学, 大学院・保健科学研究院, 教授 (10197600)
• 研究分担者: 堤 香織 北海道大学, 大学院・保健科学研究院, 助教 (80344505)
• 研究期間 (年度): 2010 – 2012
• キーワード: 生物影響 / 放射線作用機構

研究概要

生体細胞に照射した放射線の影響を、モンテカルロ法に基づく電子線や生理活性物質の挙動に関するシミュレーションと、放射線照射後の細胞核損傷観測の両者によって解析した。その結果、放射線照射により生体内に発生する電子線のエネルギー付与過程が細胞核内のDNA損傷に強く影響すること、また細胞生存率が損傷修復を考慮した統計分布と致死確率を考慮したモデルにより説明できること等を明らかにした。

研究成果

• [雑誌論文] Simulation Study of the Radiation-Induced Bystander Effect: Modeling with Stochastically Defined Signal Reemission. (2012)
  • 著者名/発表者名: Kohei Sasaki, Kosuke Wakui, Kaori Tsutsumi, Akio Itoh, and Hiroyuki Date. A
  • 雑誌名: Computational and Mathematical Methods in Medicine Article ID 389095 巻: Volume 2012 ページ: 5
  • DOI: doi:10.1155/2012/389095
  • 査読あり
• [雑誌論文] Graphical representation of the effects on tumor and OAR for determining the appropriate fractionation regimen in radiation therapy planning. (2012)
  • 著者名/発表者名: Masahiro Mizuta, Hiroyuki Date, Seishin Takao, Naoki Kishimoto, Kenneth L. Sutherland, Rikiya Onimaru, and Hiroki Shirato.
  • 雑誌名: Medical Physics 巻: 39 (11) ページ: 6791-6795
  • DOI: doi:10.1118/1.4757580
  • 査読あり
• [雑誌論文] A Mathematical Study to Select Fractionation Regimen Based on PhysicalDose Distribution and the Linear- Quadratic Model. (2012)
  • 著者名/発表者名: Masahiro Mizuta, Seishin Takao, Hiroyuki Date, Naoki Kishimoto, Kenneth L. Sutherland, Rikiya Onimaru, and Hiroki Shirato.
  • 雑誌名: International Journal of Radiation Oncology, Biology, Physics 巻: 84, No.3 ページ: 829-833
  • DOI: doi:10.1016/ j.ijrobp.2012.01.004
  • 査読あり
• [雑誌論文] Electron Track Analysis for Damage Formation in Bio-Cells. (2011)
  • 著者名/発表者名: Y. Yoshii, K.L. Sutherland, H. Date.
  • 雑誌名: Nuclear Instruments and Methods in Physics Research B 巻: 269 ページ: 1887-1891
  • DOI: doi:10.1016/j.nimb.2011.05.028
  • 査読あり
• [雑誌論文] Radiation-induced Cancer Cell Repopulation: A possible mechanism implied by experiments using trasplantable mouse-derived sarcoma cell line. (2011)
  • 著者名/発表者名: T. Nishioka, M. Yasuda, T. Takeshima, H.Haga, Y. Miyai, K. Shibata, H. Shirato, M, Teduka and H. Date.
  • 雑誌名: Cell Structure and Function 巻: 36 ページ: 13-20
  • 査読あり
• [学会発表] Upcoming Dynamic Real-time Tumor-tracking for Lung Cancer: A Preliminary Study of its Validity. (2013)
  • 著者名/発表者名: Rie Yamazaki, Seiko Nishioka, Hiroyuki Date, Takao Koike, Hiroki Shirato, Takeshi Nishioka.
  • 学会等名: Third International Conference on Real-time Tumor-tracking Radiation Therapy with 4D Molecular Imaging Technique
  • 発表場所: Sapporo Convention Center, Sapporo, Japan
  • 年月日: 2013-02-08
• [学会発表] A Mathematical Method for Estimating Optimal Fractionation Regimen in Radiotherapy (2013)
  • 著者名/発表者名: Seishin Takao, Masahiro Mizuta, Hiroyuki Date, Yuriko Komiya, Kenneth L. Sutherland, Rikiya Onimaru, Hiroki Shirato.
  • 学会等名: Third International Conference on Real-time Tumor-tracking Radiation Therapy with 4D Molecular Imaging Technique
  • 発表場所: Sapporo Convention Center, Sapporo, Japan
  • 年月日: 2013-02-08
• [学会発表] Modeling ofRadiation-Induced Bystander Effect with Re-emitting Signals Following the Poisson Statistics. (2012)
  • 著者名/発表者名: K. Sasaki, H. Date, T. Tsujiguchi, K. Wakui and A. Itoh.
  • 学会等名: World Congress on Medical Physics and Biomedical Engineering
  • 発表場所: Beijing International Convention Center, Beijing,China
  • 年月日: 20120526-31
• [学会発表] Analysis of Cell Surviving Fractionwith Non-Lethal Probability for Radiation Exposure. (2012)
  • 著者名/発表者名: Kosuke Wakui, Kohei Sasaki, HiroyukiDate.
  • 学会等名: World Congress on Medical Physics and Biomedical Engineering
  • 発表場所: Beijing International Convention Center, Beijing, China
  • 年月日: 20120526-31
• [学会発表] A Simulation Study of Radiation Therapy Based on LQ Model. (2011)
  • 著者名/発表者名: Naoki Kishimoto, Yuriko Komiya, Hiroyuki Date, Hiroki Shirato, Masahiro Mizuta.
  • 学会等名: Joint Meeting of the Korea-Japan Conference of Computational Statistics and the 25th Symposium of Japanese Society of Computational Statistics
  • 発表場所: Haeundae Grand Hotel, Busan, Korea.
  • 年月日: 20111111-12
• [学会発表] Microdosimetric Kinetic Analysis of the Lesions inBio-Cells by Radiation Exposure. (2011)
  • 著者名/発表者名: Y. Ohtsubo, K. Tsutsumi, K. Sasaki, K. Wakui, and H. Date.
  • 学会等名: PROGRAMME GUIDE & BOOK OF ABSTRACTS of 14th International Congress of Radiation Research (ICRR)
  • 発表場所: Palace of Culture and Science, Warsaw, Poland
  • 年月日: 20110828-0901
• [学会発表] Computational Approach for Determining the Properties of Low-Energy Electron Track. (2011)
  • 著者名/発表者名: Y. Yoshii, K. Sasaki, K.L. Sutherland, and H. Date.
  • 学会等名: PROGRAMME GUIDE & BOOK OF ABSTRACTS of 14th International Congress of Radiation Research (ICRR)
  • 発表場所: Palace of Culture and Science, Warsaw, Poland
  • 年月日: 20110828-0901
• [学会発表] Theoretical Comparison between Availabilities of Single- and Fractionated- Irradiation Therapies. (2011)
  • 著者名/発表者名: M. Mizuta, S. Takao, H. Date, N. Kishimoto, H. Shirato.
  • 学会等名: ASTRO's (American Society for Radiation Oncology) 53rd Annual Meeting inMiami Beach
  • 発表場所: Miami Beach Convention Center, Miami, FL (USA)
  • 年月日: 2011-10-26
• [学会発表] Microdosimetric Kinetic Analysis of the Relation between Energy Distribution of Photon Beam and Lesions Induced in Bio-Cells. (2011)
  • 著者名/発表者名: Y. Ohtsubo, K. Tsutsumi, K. Sasaki, K. Wakui, and H. Date.
  • 学会等名: The 6th Japan-Korea Joint Meeting on Medical Physics and the 11th Asia-Oceania Congress of Medical Physics.
  • 発表場所: Kyushu University (Fukuoka)
  • 年月日: 2011-09-29
• [学会発表] Modeling of Clustering Properties of the Electron Processes in Bio-Tissues Exposed to Ionizing Radiation. (2011)
  • 著者名/発表者名: Yuji Yoshii, Kohei Sasaki, K.L. Sutherland, and Hiroyuki Date.
  • 学会等名: The 6th Japan-Korea Joint Meeting on Medical Physics and the11th Asia-Oceania Congress of Medical Physics.
  • 発表場所: Kyushu University (Fukuoka)
  • 年月日: 2011-09-29
• [学会発表] Trial Study of a New Model for Cell Surviving Fraction. (2011)
  • 著者名/発表者名: Kosuke Wakui, Takahiro Kato, Kohei Sasaki and Hiroyuki Date.
  • 学会等名: The 6th Japan-Korea Joint Meeting onMedical Physics and the 11th Asia-Oceania Congress of Medical Physics
  • 発表場所: Kyushu University (Fukuoka)
  • 年月日: 2011-09-29
• [学会発表] An Interpretation of the Survival Curve for Cells Exposed to X-rays. (2010)
  • 著者名/発表者名: H. Date, T. Kato, K. Wakui.
  • 学会等名: 9th International Conference on the Effects of Low and Very Low Doses of Ionizing Radiation on Human Health and Biotopes.
  • 発表場所: Escola Universitaria d'Enginyeria Tecnica Industrial de Barcelona, Barcelona, Spain
  • 年月日: 20101213-15
• [学会発表] Properties of Electron Collisions with Constituent Molecules in Living Cells. (2010)
  • 著者名/発表者名: H. Date, H. Hasegawa, M. Shimozuma.
  • 学会等名: International Workshop on Plasmas with Liquids (IWPL2010)
  • 発表場所: Hotel Okudogo, Matsuyama, Ehime, Japan
  • 年月日: 20100322-24