心臓突然死ポックリ病とリポ蛋白質結合性の生理活性脂質スフィンゴシン1‐リン酸

2012 年度 研究成果報告書

• 研究課題/領域番号: 22590517
• 研究種目: 基盤研究(C)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 病態検査学
• 研究機関: 群馬大学
• 研究代表者: 中嶋 克行 群馬大学, 大学院・保健学研究科, 客員教授 (10444051)
• 研究分担者: 藤田 眞幸 慶應義塾大学, 医学部, 教授 (00211524) ; 岡島 史和 群馬大学, 生体調節研究所, 教授 (30142748)
• 研究期間 (年度): 2010 – 2012
• キーワード: スフィンゴシン 1-リン酸 / ポックリ病 / レムナント

研究概要

我々は中性脂肪が豊富なレムナントリポタンパク(レムナント)が健康な青壮年層の男性の突然死(ポックリ病)と関連していることを提唱している。しかし、その機構は不明である。本研究ではリポタンパクに濃縮しているスフィンゴシン1-リン酸(S1P)やS1P結合活性をもつアポリポタンパクM(apoM)が関与を調べた。しかし、健常者とポックリ病患者血清のS1P濃度に有意な違いは観察されなかった。apoMの2次元電気泳動パターンの違いを解析予定である。

研究成果

• [雑誌論文] Comparative reactivity of remnant-like lipoprotein particles (RLP) and low-density lipoprotein (LDL) to LDL receptor and VLDL receptor: effect of a high-dose statin on VLDL receptor expression (2012)
  • 著者名/発表者名: Imagawa M, Takahashi S, Zenimaru Y, Kimura T, Suzuki J, Miyamori I, Iwasaki T, Hattori H, Yamamoto TT, Nakano T, Nakajima K.
  • 雑誌名: Clin Chim Acta 巻: 413 ページ: 441-7
  • 査読あり
• [雑誌論文] The characteristics of remnant lipoproteins in the fasting and postprandial plasma (2012)
  • 著者名/発表者名: Nakajima K, Nakano T, Tokita Y, Nagamine T, Yatsuzuka S, Shimomura Y, Tanaka A, Sumino H, Nara M, Machida T, Murakami M.
  • 雑誌名: Clin Chim Acta 巻: 413 ページ: 1077-86
  • 査読あり
• [雑誌論文] Remnant lipoproteins are a stronger risk factor for cardiovascular events than LDL-C from the studies of autopsies in sudden cardiac death cases.Recent Advances in Cardiovascular Risk Factors (2012)
  • 著者名/発表者名: Nakajima K and Fujita MQ.
  • 雑誌名: Ed by Mehnaz Atiq. (Intech) ページ: 15-36
• [雑誌論文] Post-prandial remnant lipoprotein metabolism in autosomal recessive hypercholesterolaemia. (2012)
  • 著者名/発表者名: Tada H, Kawashiri MA, Tanaka A, Nakano T, Nakajima K, Inoue T, Noguchi T, Nakanishi C, Konno T, Hayashi K, Nohara A, Inazu A, Kobayashi J, Mabuchi H, Yamagishi M.
  • 雑誌名: Eur JClin Invest. 巻: 42 ページ: 1094-9
  • 査読あり
• [雑誌論文] ELISA system for human endothelial lipase. (2012)
  • 著者名/発表者名: Ishida T, Miyashita K, Shimizu M, Kinoshita N, Mori K, Sun L, Yasuda T, Imamura S, Nakajima K, Stanhope KL, Havel PJ, Hirata K.
  • 雑誌名: ClinChem 巻: 58 ページ: 1656-64
  • 査読あり
• [雑誌論文] Advances in Clinical Chemistry (Review) (2012)
  • 著者名/発表者名: Nakajima K, Nagamine T, Fijita MQ, Tanaka A. ApoB48
  • 雑誌名: submitted
  • 査読あり
• [雑誌論文] Effects of maximal atorvastatin and rosuvastatin treatment on markers of glucose homeostasis and inflammation. (2011)
  • 著者名/発表者名: Thongtang N, Ai M, Otokozawa S, Himbergen TV, Asztalos BF, Nakajima K, Stein E, Jones PH, Schaefer EJ.
  • 雑誌名: Am J Cardiol 巻: 107 ページ: 387-92
  • 査読あり
• [雑誌論文] Adiponectin: an independent risk factor for coronary heart disease in men in the Framingham offspring Study (2011)
  • 著者名/発表者名: Ai M, Otokozawa S, Asztalos BF, White CC, Cupples LA, Nakajima K, Lamon-Fava S, Wilson PW, Matsuzawa Y, Schaefer EJ
  • 雑誌名: Atherosclerosis 巻: 217 ページ: 543-8
  • 査読あり
• [雑誌論文] Measurement of serum remnant-like lipoprotein particle-triglyceride (RLP-TG) and RLP-TG/ total TG ratio using highly sensitive triglyceride assayreagent (2011)
  • 著者名/発表者名: Nakano T, Tokita Y, Nagamine T, Tanaka A, Okazaki M, Yatsuzuka S, Tarui N, Shimomura Y, Ando Y, Akamatsu S, Fujita MQ, Nakajima K
  • 雑誌名: Clin Chim Acta 巻: 12 ページ: 71-78
  • 査読あり
• [雑誌論文] Particle size of apoB-48 carrying lipoproteins in remnant lipoproteins isolated from postprandial plasma (2011)
  • 著者名/発表者名: Nakano T, Tanaka A, Okazaki M, Tokita Y, Nagamine T, Nakajima K.
  • 雑誌名: Ann Clin Biochem 巻: 48 ページ: 57-64
  • 査読あり
• [雑誌論文] Postprandial lipoprotein metabolism: VLDL vs chylomicrons (2011)
  • 著者名/発表者名: Nakajima K, Nakano T, Tokita Y, Nagamine T, Inazu A, Kobayashi J, Mabuchi H, Stanhope KL, Havel PJ, Okazaki M, Ai M, Tanaka A.
  • 雑誌名: Clin Chim Acta 巻: 412 ページ: 1306-1318
  • 査読あり
• [雑誌論文] Consumption of fructose and high fructose corn syrup increase postprandial triglycerides, LDL-cholesterol, and apolipoprotein-B in young men and women. (2011)
  • 著者名/発表者名: Stanhope KL, Bremer AA, Medici V, Nakajima K, Ito Y, Nakano T, Chen G, Fong TH, Lee V, Menorca RI, Keim NL, Havel PJ.
  • 雑誌名: J Clin Endocrinol Metab. 巻: 96 ページ: 3783-91
  • 査読あり
• [雑誌論文] Metabolic responses to prolonged consumption of glucose- and fructose-sweetened beverages are not associated with postprandial or 24-h glucose and insulin excursions (2011)
  • 著者名/発表者名: Stanhope KL, Griffen SC, Bremer AA, Vink RG, Schaefer EJ, Nakajima K, Schwarz JM, Beysen C, Berglund L, Keim NL, Havel PJ.
  • 雑誌名: Am J Clin Nutr 巻: 94 ページ: 112-9
  • 査読あり
• [雑誌論文] Non-HDL cholesterol shows improved accuracy for cardiovascular risk score classification compared to direct or calculated LDL cholesterol in a dyslipidemic population (2011)
  • 著者名/発表者名: van Deventer HE, Miller WG, Myers GL, Sakurabayashi I, Bachmann LM, Caudill SP,Dziekonski A, Edwards S, Kimberly MM, Korzun WJ, Leary ET, Nakajima K, Nakamura M, Shamburek RD, Vetrovec GW, Warnick GR, Remaley AT
  • 雑誌名: Clin Chem 巻: 57 ページ: 490-501
  • 査読あり
• [雑誌論文] Association of angiopoietin-like protein 3 with hepatic triglyceride lipase and lipoprotein lipase activities in human plasma (2010)
  • 著者名/発表者名: Nakajima K, Kobayashi J, Mabuchi H, Nakano T, Tokita Y, Nagamine T, Imamura S, Ai M, Otokozawa S, Schaefer EF
  • 雑誌名: Ann Clin Biochem 巻: 47 ページ: 423-31
  • 査読あり
• [雑誌論文] Direct assessment of plasma low density lipoprotein and high density lipoprotein cholesterol levels and coronary heart disease: Results from the Framingham Offspring Study (2010)
  • 著者名/発表者名: Otokozawa S, Ai M, Asztalos BF, White CC, Demissie-Banjaw S, Cupples LA, Nakajima K, Wilson PW, Schaefer EJ.
  • 雑誌名: Atherosclerosis 巻: 213 ページ: 251-5
  • 査読あり
• [雑誌論文] Remaley ATSeven direct methods for measuring HDL and LDL cholesterol compared with ultracentrifugation reference measurement procedures (2010)
  • 著者名/発表者名: Miller WG, Myers GL, Sakurabayashi I, Bachmann LM, Caudill SP, Dziekonski A, Edwards S, Kimberly MM, Korzun WJ, Leary ET, Nakajima K, Nakamura M, Nilsson G, Shamburek RD, Vetrovec GW, Warnick GR
  • 雑誌名: Clin Chem. 巻: 56(6) ページ: 977-86
  • 査読あり
• [雑誌論文] Small dense LDL cholesterol and coronary heart disease: results from the Framingham Offspring Study (2010)
  • 著者名/発表者名: Ai M, Otokozawa S, Asztalos BF, Ito Y,Nakajima K, White CC, Cupples LA, Wilson PW, Schaefer EJ.
  • 雑誌名: Clin Chem 巻: 56 ページ: 967-76
  • 査読あり
• [雑誌論文] Pokkuri Death Syndrome; Sudden Cardiac Death Cases without Coronary Atherosclerosis in South Asian Young Males. (2010)
  • 著者名/発表者名: Nakajima K, Takeichi S, Nakajima Y, Fujita MQ.
  • 雑誌名: Forensic Sci Int 巻: 207 ページ: 6-13
  • 査読あり
• [学会発表] Panuwat Chutivongse, Nantana Sirisup, Sanae Takeichi, Masaki Q Fujita: The relationship between the severity of coronary artery atherosclerosis and heart weight in Asian sudden death cases (2012)
  • 著者名/発表者名: Katsuyuki Nakajima Yasuhiro Nakajima
  • 学会等名: The XVI International Symposium on Atherosclerosis (ISA2012)
  • 発表場所: Sydney Australia
  • 年月日: 20120325-29
• [学会発表] Ernst Schaefer Katsuyuki Nakajima: Plasma diagnostic markers of fatty liver in subjects with or without metabolic syndrome (2012)
  • 著者名/発表者名: Shinichi Yatsuzuka, Masako Akuzawa, Masaki Takahashi, Younosuke Shimomura, Yoshitaka Ando, Isao Kobayashi, Takamitsu Nakano, Yoshiharu Tokita, Takeaki Nagamine, Hiromi Ono, Akira Tanaka
  • 学会等名: The XVI International Symposium on Atherosclerosis (ISA2012)
  • 発表場所: Sydney Australia
  • 年月日: 20120325-29
• [学会発表] Effectof very-low-density lipoprotein (VLDL) Receptor on plasma triglyceride and the increased VLDL receptor expression by high dose statin, low fat and low glucose (2012)
  • 著者名/発表者名: Michiko Imagawa, Sadao Takahashi1, Yasuo Zenimaru, Mai Ichikawa, Tomoko Kimura, Satsuki Sato, Jinya Suzuki, Isamu Miyamori, Takamitsu Nakano, Katsuyuki Nakajima
  • 学会等名: The XVI International Symposium on Atherosclerosis (ISA2012)
  • 発表場所: Sydney Australia
  • 年月日: 20120325-29
• [学会発表] The characteristics of remnant lipoproteins in the fasting and postprandial plasma. (2012)
  • 著者名/発表者名: Nakajima K, Nakano T, Y. Tokita, T. Nagamine, Yatsuzuka S, Shimomura Y, Tanaka A, Sumino H, Nara M, Machida T, Murakami M.
  • 学会等名: 3rd International Symposium on Chylomicrons in Disease
  • 発表場所: Sydney, Australia
  • 年月日: 20120323-24
• [学会発表] The presence of postprandial remnant lipoproteins in the fasting plasma with TG levels below 150 mg/dL (2011)
  • 著者名/発表者名: Nakajima K, Nakano T, Tokita Y, Nagamne T, Yatsuzuka S, Shimomura Y. Tanaka
  • 学会等名: American Association of Clinical Chemistry, Lipoproteins and Vascular Disease Division
  • 発表場所: Atlanta, Georgia, USA
  • 年月日: 20110724-27
• [学会発表] Measurement of plasma remnant lipoproteins and its clinical significance (2011)
  • 著者名/発表者名: Katsuyuki Nakajima
  • 学会等名: American Association of Clinical Chemistry, Lipoproteins and Vascular Disease Division
  • 発表場所: Atlanta, Georgia, USA
  • 年月日: 2011-07-25