IgA腎症の扁桃特異的細菌叢の検討

2012 年度 研究成果報告書

• 研究課題/領域番号: 22590891
• 研究種目: 基盤研究(C)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 腎臓内科学
• 研究機関: 兵庫医科大学 (2012); 大阪大学 (2010-2011)
• 研究代表者: 長澤 康行 兵庫医科大学, 医学部, 講師 (10379167)
• 研究期間 (年度): 2010 – 2012
• キーワード: IgA腎症 / 扁桃 / 細菌叢 / Treponema sp. / Haemophilus segnis / Campylobacter rectus

研究概要

IgA腎症患者の扁桃特異的細菌叢の同定をDDGE法により行いTreponemasp.,Haemophilussegnis,Campylobacterrectusであることを同定した。IgA腎症患者の扁桃特異的細菌叢と扁桃摘出+ステロイドパルス療法の治療効果との関連性について検討を行い、このうち2種の細菌が治療効果と強い相関があり、この菌の検出により治療予測能があることを確認した。

研究成果

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• [雑誌論文] Retention of fetuin-A in renal tubular lumen protects the kidney from nephrocalcinosis in rats. (2013)
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• [雑誌論文] Yoshitaka Isaka Quantitative change ofIgA hinge O-glycan composition is a novel marker of therapeutic responses of IgA (2012)
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• [雑誌論文] Themitochondrial protein frataxin is downregulated in hemodialysispatients. (2012)
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  • 査読あり
• [雑誌論文] Gene polymorphismscontributing to hypertension in immunoglobulin A nephropathy. (2012)
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• [雑誌論文] Moriyama TSelf-reported Sleep Duration and Prediction of Proteinuria: A Retrospective Cohort Study.. (2012)
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• [雑誌論文] Intact fibroblast growth factor 23 levels predict incident cardiovascular event before but not after the start of dialysis. (2012)
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• [雑誌論文] Isaka Y.Cigarette smoking and chronic kidney diseases. (2012)
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• [雑誌論文] A candidate gene approach to genetic contributors tothe development of IgA nephropathy. (2012)
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• [雑誌論文] Serum hepcidin-25 levels and anemia innon-dialysis chronic kidney disease patients: a cross-sectional study (2012)
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  • 雑誌名: Nephrol Dial Transplant 巻: 27(3) ページ: 1076-83
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  • 査読あり
• [雑誌論文] Towards developing new strategies to reduce the adverse side-effects of nonsteroidalanti-inflammatory drugs. (2012)
  • 著者名/発表者名: Kawada N, Moriyama T, Kitamura H, Yamamoto R, Furumatsu Y, Matsui I, Takabatake Y, Nagasawa Y, Imai E, Wilcox CS, Rakugi H, Isaka Y.
  • 雑誌名: Clin ExpNephrol. 巻: 16(1) ページ: 25-9
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  • 査読あり
• [雑誌論文] Microarray analysis of tonsils of IgA nephropathy patients. (2011)
  • 著者名/発表者名: Iwatani H, Iio K, Nagasawa Y, Yamamoto R, Horii A, Okuzaki D, Inohara H, Nojima H, Imai E, Rakugi H, Isaka Y.
  • 雑誌名: Adv Otorhinolaryngol. 巻: 72 ページ: 75-8
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• [雑誌論文] Effects of nicorandil on the reduction of BNP levels in patients with chronic kidney disease. (2011)
  • 著者名/発表者名: Kimura T, Kitamura H, Inoue K, Kawada N, Matsui I, Nagasawa Y, Obi Y, Shinzawa M, Sakata Y, Hamono T, Rakugi H, Isaka Y.
  • 雑誌名: Clin Exp Nephrol. 巻: 15(6) ページ: 854-60
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  • 査読あり
• [雑誌論文] Oxford IgA nephropathy classification: valid for children (2010)
  • 著者名/発表者名: Yamamoto R, Nagasawa Y. Pathology
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  • 査読あり
• [雑誌論文] Maruhashi Therapeutic Apheresis (2010)
  • 著者名/発表者名: Nagasawa Y, Yamamoto R
  • 雑誌名: Liver Transplantation Transplantationsmedizin2010 巻: 22 ページ: 339-343
• [雑誌論文] Impact of age and overt proteinuria on outcomes of stage 3-5 chronic kidney disease in a referred cohort (2010)
  • 著者名/発表者名: Obi Y, Kimura T, Nagasawa Y, Yamamoto R, Yasuda K, Sasaki K, Kitamura H, Imai E, Rakugi H,Isaka Y, Hayashi T.
  • 雑誌名: Clin J Am Soc Nephrol 巻: 5(9) ページ: 1558-65
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  • 査読あり
• [雑誌論文] Urinary Type IV Collagen in Nondiabetic Kidney Disease. (2010)
  • 著者名/発表者名: Furumatsu Y, Nagasawa Y, Shoji T, Yamamoto R, Iio K, Matsui I, Takabatake Y, Kaimori JY, Iwatani H, Kaneko T, Tsubakihara Y, Imai E, Isaka Y, Rakugi H.
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  • DOI: doi:10.1093/ndt/gfp738.
  • 査読あり
• [雑誌論文] Rakugi H. Cigarette Smoking and Progression of IgA Nephropathy Am (2010)
  • 著者名/発表者名: Yamamoto R, Nagasawa Y, Shoji T, Iwatani H, Hamano T, Kawada N, Moriyama T, Horio M, Yamauchii A, Tsubakihara Y, Imai E, Isaka Y
  • 雑誌名: J Kidney Dis 巻: 56(2) ページ: 313-24
  • DOI: doi:10.1053/j.ajkd.2010.02.351.
  • 査読あり
• [学会発表] Intravenous methylprednisolone therapy acceleratedcomplete remission of proteinuria in adult patients with minimal change nephrotic syndrome. (2012)
  • 著者名/発表者名: Shinzawa M, Yamamoto R, Nagasawa Y, Oseto S, Mori D, Niihata K, Tomida K, Izumi M, Fukunaga M, Yamauchi A, Tsubakihara Y, Rakugi H, Isaka Y.
  • 学会等名: American Society of Nephrology Kidney Week Annual Meeting
  • 発表場所: San Diego, USA
  • 年月日: 2012-11-02
• [学会発表] Bacteria specific to tonsil in IgA nephropathy patients predicts the remission by the treatment of tonsillectomy and corticosteroid pulse. (2012)
  • 著者名/発表者名: Nagasawa Y, Iio K, Iwatani H, Yamamoto R, Shinzawa M, Imai E, Nakanishi T, Rakugi H, Isaka Y.
  • 学会等名: American Society of Nephrology Kidney Week 2012 Annual Meeting
  • 発表場所: San Diego, USA
  • 年月日: 2012-11-01
• [学会発表] Methylprednisolone pulse therapy accelerated complete remission of proteinuria in adult-onset minimal change nephrotic syndrome patients. (2012)
  • 著者名/発表者名: Shinzawa M, Yamamoto R, Nagasawa Y, Oseto S, Mori D, Niihata K, Fukunaga M, Yamauchi A, Tsubakihara Y, Rakugi H, Isaka Y.
  • 学会等名: XLVIIII ERA-EDTA congress
  • 発表場所: Paris, France
  • 年月日: 2012-05-25
• [学会発表] Quantitative Analysis of O-Glycosylation of IgA Hinge Portion (HP) in IgA Nephropathy (IgAN) Patients and Its Responsiveness to the Therapy of Tonsillectomy Combined with Corticosteroid IV (TLX+S). (2011)
  • 著者名/発表者名: Iwatani H, Nagasawa Y, Inoue T, Ueda Y,Yamamoto R, Shinzawa M, Obi Y, Teranishi J, Ishigami T, Iijima H, Wada Y, Rakugi H, Isaka Y.
  • 学会等名: American Society of Nephrology
  • 発表場所: Philadelphia,USA
  • 年月日: 2011-11-12
• [学会発表] ACE Insertion/Deletion (I/D) Polymorphism Predicts RenoprotectiveEffectiveness of Renin-Angiotensin System Brockade (RASb), along with Progression, in IgA Nephropathy (IgAN). (2011)
  • 著者名/発表者名: Teranishi J, Yamamoto R, Nagasawa Y, Shoji T, Uehata T, Okada N, Yamauchi A, Tsubakihara Y, Rakugi H, Isaka Y.
  • 学会等名: American Society of Nephrology
  • 発表場所: Philadelphia,USA
  • 年月日: 2011-11-11
• [学会発表] A Candidate Gene Approach to Genetic Contributors to Development of IgA Nephropathy. (2011)
  • 著者名/発表者名: Yamamoto R, Nagasawa Y, Shoji T, KatakamiN, Ohtoshi K, Hayaishi-Okano R, Yamasaki Y, Yamauchi A, Tsubakihara Y, Imai E, Rakugi H, Isaka Y.
  • 学会等名: American Society of Nephrology
  • 発表場所: Philadelphia,USA
  • 年月日: 2011-11-11
• [学会発表] Factor Responsible for Hematuria in IgA Nephropathy (2010)
  • 著者名/発表者名: Iwatani H, Nagasawa Y, Yamamoto R, Iio K, Mizui M, Horii A, Rakugi H, Isaka Y.
  • 学会等名: American Society of Nephrology
  • 発表場所: Denver,USA
  • 年月日: 2010-11-18
• [学会発表] Cigarette Smoking Abrogates a Renoprotective Effect of Renin-Angiotensin-Aldosterone System (RAAS) Blockade in Patients with IgA Nephropathy (2010)
  • 著者名/発表者名: Yamamoto R, Nagasawa Y, Shoji T, Kawada N,Horio M, Moriyama T, Yamauchi A, Tsubakihara Y, Rakugi H, Isaka Y.
  • 学会等名: American Society of Nephrology
  • 発表場所: Denver,USA
  • 年月日: 2010-11-18
• [学会発表] Combination of Tonsillectomy and Corticosteroid Suppressed Recurrence of Urinary Protein and Occult Blood in Patients with IgA Nephropathy,Compared with Corticosteroid Alone (2010)
  • 著者名/発表者名: Takahashi A, Yamamoto R, Nagasawa Y, Iwatani H, Iio K, Shinzawa M, Horii A,Yamauchi A, Rakugi H, Isaka Y.
  • 学会等名: AmericanSociety of Nephrology
  • 発表場所: Denver,USA
  • 年月日: 2010-11-18
• [学会発表] GenePolymorphisms Contributing to Hypertensionin IgA Nephropathy (2010)
  • 著者名/発表者名: Shinzawa M, Yamamoto R, Nagasawa Y, Shoji T, Okada T, Yamauchi A, Tsubakihara Y, Imai E, Rakugi H, Isaka Y.
  • 学会等名: American Society ofNephrology
  • 発表場所: Denver,USA
  • 年月日: 2010-11-17
• [学会発表] ACE Insertion/Deletion (I/D) polymorphism predicted renoprotective effectiveness of renin-angiotensin system (RAS) blockade in patients with IgA nephropathy. (2010)
  • 著者名/発表者名: Teranishi J, Yamamoto R, Nagasawa Y, ShojiY, Iwatani H, Okada N, Moriyama T, Yamauchi A, Tsubakihara Y, Imai E, Rakugi H, Isaka Y.
  • 学会等名: XLVIIII ERA-EDTA congress
  • 発表場所: Paris, France
  • 年月日: 2010-05-26