白血病予後を司るNPM1とETS遺伝子MEFの相互作用の解明

2012 年度 研究成果報告書

• 研究課題/領域番号: 22591040
• 研究種目: 基盤研究(C)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 血液内科学
• 研究機関: 長崎大学
• 研究代表者: 宮崎 泰司 長崎大学, 大学院・医歯薬学総合研究科, 教授 (40304943)
• 連携研究者: 安東 恒史 長崎大学, 大学病院, 医員 (90571357)
• 研究期間 (年度): 2010 – 2012
• キーワード: 血液腫瘍学

研究概要

白血病細胞においてNPM1蛋白はETS転写因子であるMEF蛋白と結合しMEFの転写活性能を抑制した。急性骨髄性白血病にみられる変異型NPM1は逆にMEF転写活性能および細胞形質転換能を増強した。MEF蛋白はHDM1遺伝子プロモーターを活性化し、患者検体においてNPM1変異の有無、HDM1発現はMEF発現と有意に関連していた。NPM1変異はMEFを通じてP53経路で白血病化に係わる可能性がある。(J Biol Chem 2013;288(13):9457-67.)

研究成果

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