ヒトの肝臓を主座とする遺伝性疾患を有するマウスモデルの創生

2011 年度 実績報告書

• 研究課題/領域番号: 22659147
• 研究機関: 広島大学
• 研究代表者: 茶山 一彰 広島大学, 大学院・医歯薬学総合研究科, 教授 (00211376)
• キーワード: 肝臓学 / ノックアウトマウス / トランスジェニックマウス / 不死化肝細胞

研究概要

ヒトの遺伝性疾患は、ノックアウトマウスなどを使用して研究されていることが多い。しかし、マウスとヒトの病態は必ずしも同一ではなく、また、マウスで耐性致死であるために良好なモデルが作製できない場合も多い。また、ノックアウトマウスは作製に多大な時間と人手を要するため、わずかの違いを有するマウスを作製するのにも再度全く同じ手間を要する。本研究では、培養ヒト肝細胞に遺伝子導入することにより、ヒトの疾患と同様の状態の肝細胞を作製し、この細胞をuPA-scid mouseに移植することにより、遺伝病状態のヒト肝臓を有するマウスを作製することを目的として研究を行った。このマウスに、遺伝病の遺伝子を導入することは技術的に困難であったが、ヒト肝細胞キメラマウスにB型肝炎ウイルスを感染させ、さらにヒトリンパ球を投与することにより、ヒト肝細胞キメラマウスに劇症肝炎に類似した肝細胞の広範な壊死をもたらすモデルを作製することができた。この肝炎モデルではこれまでに想定されていたcytotoxicTlymphocyteではなく、FAS抗原を提示している肝細胞に対するNatural killer cellと樹状細胞が重要な役割を果たしていることが明らかになった。さらに、アルファインターフェロン、ガンマインターフェロンはこのモデルでは重要な役割を果たしておらず、他のサイトカインが肝炎の発症に必要であることが想定された。B型劇症肝炎は遺伝病ではないが、劇症肝炎も治療がきわめて困難な疾患であり、貴重なモデルを作製することができた。

研究成果

• [雑誌論文] Toward the establishment of a prediction system for the personalized treatment of chronic hepatitis C (2012)
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• [雑誌論文] Impact of pegylated interferon therapy on outcomes of patients with hepatitis C virus-related hepatocellular carcinoma after curative hepatic resection (2012)
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• [雑誌論文] Severe necroinflammatory reaction caused by natural killer by Fas/FasL interaction and dendritic cells in human hepatocyte chimeric mouse (2012)
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  • 雑誌名: Hepatology 巻: (in press)
  • DOI: 10.1002/hep.25651
  • 査読あり
• [雑誌論文] IL28B polymorphism is associated with fatty change in the liver of chronic hepatitis C patients (2012)
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  • DOI: 10.1007/s00535-012-0550-y
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• [雑誌論文] Serum PAI-1 is a novel predictor for response to pegylated interferon-alpha-2b plus ribavirin therapy in chronic hepatitis C virus infection (2012)
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• [雑誌論文] Hepatocellular carcinoma : towards personalized medicine (2012)
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• [雑誌論文] Combination of hepatitis B viral antigens and DNA for prediction of relapse after discontinuation of nucleos(t)ide analogs in patients with chronic hepatitis B (2012)
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  • DOI: 10.1111/j.1872-034X.2011.00910.x
  • 査読あり
• [雑誌論文] Efficacy and safety of telaprevir, a new protease inhibitor, for difficult-to-treat patients with genotype 1 chronic hepatitis C (2012)
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  • 雑誌名: J Viral Hepat 巻: 19 ページ: e134-142
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  • 査読あり
• [雑誌論文] Prevalence and associated metabolic factors of nonalcoholic fatty liver disease in the general population from 2009 to 2010 in Japan : a multicenter large retrospective study (2012)
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  • DOI: 10.1007/s00535-012-0533-z
  • 査読あり
• [雑誌論文] Validation of the FIB4 index in a Japanese nonalcoholic fatty liver disease population (2012)
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  • 雑誌名: BMC Gastroenterol 巻: (Epub)
  • DOI: 10.1186/1471-230X-12-2
  • 査読あり
• [雑誌論文] Identification of the Niemann-Piok C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor (2012)
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  • 雑誌名: Nat Med 巻: 18 ページ: 281-285
  • DOI: 10.1038/nm.2581
  • 査読あり
• [雑誌論文] Telaprevir with peginterferon and ribavirin for treatment-naive patients chronically infected with HCV of genotype 1 in Japan (2012)
  • 著者名/発表者名: Kumada H, Toyota J, Okanoue T, Chayama K, Tsubouchi H, Hayashi N
  • 雑誌名: J Hepatol 巻: 56 ページ: 78-84
  • DOI: 10.1016/j.jhep.2011.07.016
  • 査読あり
• [雑誌論文] Atorvastatin improves disease activity of nonalcoholic steatohepatitis partly through its tumour necrosis factor-alpha-lowering property (2012)
  • 著者名/発表者名: Hyogo H, Yamagishi SI, Maeda S, Kimura Y, Ishitobi T, Chayama K
  • 雑誌名: Dig Liver Dis 巻: (in press)
  • DOI: 10.1016/j.dld.2011.12.013
  • 査読あり
• [雑誌論文] Dual therapy with the nonstructural Protein 5A Inhibitor, BMS-790052, and the Nonstructural Protein 3 Protease Inhibitor, BMS-650032, in Hepatitis C Virus Genotype 1b-Infected Null Responders (2012)
  • 著者名/発表者名: Chayama K, Takahashi S, Toyota J, Karino Y, Ikeda K, Ishikawa H, Watanabe H, McPhee F, Hughes E, Kumada H
  • 雑誌名: Hepatology 巻: 55 ページ: 742-8
  • DOI: 10.1002/hep.24724
  • 査読あり
• [雑誌論文] Amino Acid Substitution in HCV Core/NS5A Region and Genetic Variation Near IL28B Gene Affect Treatment Efficacy to Interferon plus Ribavirin Combination Therapy (2012)
  • 著者名/発表者名: Akuta N, Suzuki F, Hirakawa M, Kawamura Y, Sezaki H, Suzuki Y, Hosaka T, Kobayashi M, Kobayashi M, Saitoh S, Arase Y, Ikeda K, Chayama K, Nakamura Y, Kumada H
  • 雑誌名: Intervirology 巻: 55 ページ: 231-41
  • DOI: 10.1159/000328327
  • 査読あり
• [雑誌論文] Rapid emergence of telaprevir resistant hepatitis C virus strain from wildtype clone in vivo (2011)
  • 著者名/発表者名: Hiraga N, Imamura M, Abe H, Hayes CN, Kono T, Onishi M, Tsuge M, Takahashi S, Ochi H, Iwao E, Kamiya N, Yamada I, Tateno C, Yoshizato K, Matsui H, Kanai A, Inaba T, Tanaka S, Chayama K.
  • 雑誌名: Hepatology 2011 巻: 54 ページ: 781-788
  • DOI: doi:10.1002/hep.24460
  • 査読あり
• [雑誌論文] IL28 variation affects expression of interferon stimulated genes and peg-interferon and ribavirin therapy (2011)
  • 著者名/発表者名: Abe H, Hayes CN, Ochi H, Maekawa T, Tsuge M, Miki D, Mitsui F, Hiraga N, Imamura M, Takahashi S, Kubo M, Nakamura Y, Chayama K.
  • 雑誌名: Hepatol 2011 巻: 54 ページ: 1094-1101
  • DOI: doi:10.1016/j.jhep.2010.09.019
  • 査読あり
• [雑誌論文] A randomized phase II trial of intra-arterial chemotherapy using SM-11355 (Miriplatin) for hepatocellular carcinoma (2011)
  • 著者名/発表者名: Okusaka T, Kasugai H, Ishii H, Kudo M, Sata M, Tanaka K, Shioyama Y, Chayama K, Kumada H, Yoshikawa M, Seki T, Saito H, Hayashi N, Shiratori K, Okita K, Sakaida I, Honda M, Kusumoto Y, Tsutsumi T, Sakata K
  • 雑誌名: Invest New Drugs 巻: (Published online : 21 Dec.)(Epub)
  • DOI: 10.1007/s10637-011-9776-4
  • 査読あり
• [雑誌論文] Treatment of chronic hepatitis B with nucleos(t)ide analogues (2011)
  • 著者名/発表者名: Ohishi W, Chayama K
  • 雑誌名: Hepatol Res 巻: 42 ページ: 219-25
  • DOI: 10.1111/j.1872-034X.2011.00921.x
  • 査読あり
• [雑誌論文] Recent trend of clinical features in patients with hepatocellular carcinoma (2011)
  • 著者名/発表者名: Nagaoki Y, Hyogo H, Aikata H, Tanaka M, Naeshiro N, Nakahara T, Honda Y, Miyaki D, Kawaoka T, Takaki S, Hiramatsu A, Waki K, Imamura M, Kawakami Y, Takahashi S, Chayama K
  • 雑誌名: Hepatol Res 巻: (Epub 13 Dec.)(Epub)
  • DOI: 10.1111/j.1872-034X.2011.00929.x
  • 査読あり
• [雑誌論文] Platelet count for predicting fibrosis in nonalcoholic fatty liver disease (2011)
  • 著者名/発表者名: Yoneda M, Fujii H, Sumida Y, Hyogo H, Itoh Y, Ono M, Eguchi Y, Suzuki Y, Aoki N, Kanemasa K, Imajo K, Chayama K, Saibara T, Kawada N, Fujimoto K, Kohgo Y, Yoshikawa T, Okanoue T, Japan Study Group of Nonalcoholic Fatty Liver D
  • 雑誌名: J Gastroenterol 巻: 46 ページ: 1300-1306
  • DOI: 10.1007/s00535-011-0436-4
  • 査読あり
• [雑誌論文] Clinical outcome of esophageal varices after hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma with major portal vein tumor thrombus (2011)
  • 著者名/発表者名: Kodama H, Aikata H, Murakami E, Miyaki D, Nagaoki Y, Hashimoto Y, Azakami T, Katamura Y, Kawaoka T, Takaki S, Hiramatsu A, Waki K, Imamura M, Kawakami Y, Takahashi S, Ishikawa M, Kakizawa H, Awai K, Kenjo M, Nagata Y, Chayama K
  • 雑誌名: Hepatol Res 巻: 41 ページ: 1046-1056
  • DOI: 10.1111/j.1872-034X.2011.00857.x
  • 査読あり
• [雑誌論文] Eradication of hepatitis C virus genotype 1 after liver transplantation by interferon therapy before surgery : Report of three patients with analysis of interleukin-28 polymorphism, hepatitis C virus core region and in terferon-sensitivity determining region (2011)
  • 著者名/発表者名: Kawaoka T, Aikata H, Miyaki D, Murakami E, Azakami T, Takaki S, Nagaoki Y, Hashimoto Y, Katamura Y, Hiramatsu A, Waki K, Hiraga N, Miki D, Tsuge M, Imamura M, Kawakami Y, Takahashi S, Ochi H, Tashiro H, Ohdan H, Chayama K
  • 雑誌名: Hepatol Res 巻: 41 ページ: 1126-1131
  • DOI: 10.1111/j.1872-034X.2011.00853.x
  • 査読あり
• [雑誌論文] A huge metastatic liver tumor from leiomyosarcoma of the inferior venacava : report of a case (2011)
  • 著者名/発表者名: Hashimoto M, Kobayashi T, Tashiro H, Amano H, Oshita A, Tanimoto Y, Kuroda S, Tazawa H, Aikata H, Chayama K, Fujii M, Arihiro K, Ohdan H
  • 雑誌名: Surg Today 巻: (Epub 11 Nov.)(Epub)
  • DOI: 10.1007/s00595-011-0070-z
  • 査読あり
• [雑誌論文] Lymphocyte subset characterization associated with persistent hepatitis C virus infection and subsequent progression of liver fibrosis (2011)
  • 著者名/発表者名: Yoshida K, Ohishi W, Nakashima E, Fujiwara S, Akahoshi M, Kasagi F, Chayama K, Hakoda M, Kyoizumi S, Nakachi K, Hayashi T, Kusunoki Y
  • 雑誌名: Hum Immunol 巻: 72 ページ: 821-826
  • DOI: 10.1016/j.humimm.2011.05.029
  • 査読あり
• [雑誌論文] Prevention of hepatitis B virus reactivation in immunosuppressive therapy or chemotherapy (2011)
  • 著者名/発表者名: Ohishi W, Chayama K
  • 雑誌名: Clin Exp Nephrol 巻: 15 ページ: 634-640
  • DOI: 10.1007/s10157-011-0464-7
  • 査読あり
• [雑誌論文] A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population (2011)
  • 著者名/発表者名: Mbarek H, Ochi H, Urabe Y, Kumar V, Kubo M, Hosono N, Takahashi A, Kamatani Y, Miki D, Abe H, Tsunoda T, Kamatani N, Chayama K, Nakamura Y, Matsuda K
  • 雑誌名: Hum Mol Genet 巻: 20 ページ: 3884-3892
  • DOI: 10.1093/hmg/ddr301
  • 査読あり
• [雑誌論文] IL28B polymorphism may guide pegylated interferon plus ribavirin therapy even after curative treatment for hepatitis C virus-related hepatocellular carcinoma (2011)
  • 著者名/発表者名: Kawaoka T, Aikata H, Takaki S, Hiramatsu A, Waki K, Hiraga N, Miki D, Tsuge M, Imamura M, Kawakami Y, Takahashi S, Ochi H, Tashiro H, Ohdan H, Chayama K
  • 雑誌名: J Viral Hepat 巻: 18 ページ: e550-560
  • DOI: 10.1111/j.1365-2893.2011.01468.x
  • 査読あり
• [雑誌論文] Hepatitis C virus infection suppresses the interferon response in the liver of the human hepatocyte chimeric mouse (2011)
  • 著者名/発表者名: Tsuge M, Fujimoto Y, Hiraga N, Zhang Y, Ohnishi M, Kohno T, Abe H, Miki D, Imamura M, Takahashi S, Ochi H, Hayes CN, Miya F, Tsunoda T, Chayama K
  • 雑誌名: PLoS One 巻: 6 ページ: e23856
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  • 査読あり
• [雑誌論文] Impact of viral amino acid substitutions and host interleukin-28b polymorphism on replication and susceptibility to interferon of hepatitis C virus (2011)
  • 著者名/発表者名: Hiraga N, Abe H, Imamura M, Tsuge M, Takahashi S, Hayes CN, Ochi H, Tateno C, Yoshizato K, Nakamura Y, Kamatani N, Chayama K
  • 雑誌名: Hepatology 巻: 54 ページ: 764-771
  • DOI: 10.1002/hep.24453
  • 査読あり
• [雑誌論文] Inverse association of IL28B genotype and liver mRNA expression of genes promoting or suppressing antiviral state (2011)
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  • 雑誌名: J Med Virol 巻: 83 ページ: 1597-1607
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  • 査読あり
• [雑誌論文] In vivo adaptation of hepatitis C virus in chimpanzees for efficient virus production and evasion of apoptosis (2011)
  • 著者名/発表者名: Saeed M, Shiina M, Date T, Akazawa D, Watanabe N, Murayama A, Suzuki T, Watanabe H, Hiraga N, Imamura M, Chayama K, Choi Y, Krawczynski K, Liang TJ, Wakita T, Kato T
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  • 査読あり
• [雑誌論文] Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers (2011)
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  • 査読あり
• [雑誌論文] Achievement of Sustained Viral Response after Switching Treatment from Pegylated Interferon alpha-2b to alpha-2a and Ribavirin in Patients with Recurrence of Hepatitis C Virus Genotype 1 Infection after Liver Transplantation : A Case Report (2011)
  • 著者名/発表者名: Kawaoka T, Hiraga N, Takahashi S, Takaki S, Tsuge M, Nagaoki Y, Hashimoto Y, Katamura Y, Miki D, Hiramatsu A, Waki K, Imamura M, Kawakami Y, Aikata H, Ochi H, Tashiro H, Ohdan H, Chayama K
  • 雑誌名: Intervirology 巻: (Epub 25 Aug.)(Epub)
  • DOI: 10.1159/000328661
  • 査読あり
• [雑誌論文] Will there be an HCV meeting in 2020? Summary of the 17th international meeting on hepatitis C virus and related viruses (2011)
  • 著者名/発表者名: Wakita T, Suzuki T, Evans MJ, Shimotohno K, Chayama K, Matsuura Y, Hijikata M, Moriishi K, Seya T, Enomoto N, Koike K, Kato N, Kanto T, Hotta H
  • 雑誌名: Gastroenterology 巻: 141 ページ: e1-5
  • DOI: 10.1053/j.gastro.2011.05.027
  • 査読あり
• [雑誌論文] Effects of hepatitis B virus infection on the interferon response in immunodeficient human hepatocyte chimeric mice (2011)
  • 著者名/発表者名: Tsuge M, Takahashi S, Hiraga N, Fujimoto Y, Zhang Y, Mitsui F, Abe H, Kawaoka T, Imamura M, Ochi H, Hayes CN, Chayama K
  • 雑誌名: J Infect Dis 巻: 204 ページ: 224-228
  • DOI: 10.1093/infdis/jir247
  • 査読あり
• [雑誌論文] Treatment strategy for early hepatocellular carcinomas : comparison of radiofrequency ablation with or without transcatheter arterial chemoembolization and surgical resection (2011)
  • 著者名/発表者名: Tashiro H, Aikata H, Waki K, Amano H, Oshita A, Kobayashi T, Tanimoto Y, Kuroda S, Tazawa H, Chayama K, Asahara T, Ohdan H
  • 雑誌名: J Surg Oncol 巻: 104 ページ: 3-9
  • DOI: 10.1002/jso.21745
  • 査読あり
• [雑誌論文] Antiviral effects of peginterferon alpha-2b and ribavirin following 24-week monotherapy of telaprevir in Japanese hepatitis C patients (2011)
  • 著者名/発表者名: Ozeki I, Akaike J, Karino Y, Arakawa T, Kuwata Y, Ohmura T, Sato T, Kamiya N, Yamada I, Chayama K, Kumada H, Toyota J
  • 雑誌名: J Gastroenterol 巻: 46 ページ: 929-937
  • DOI: 10.1007/s00535-011-0411-0
  • 査読あり
• [雑誌論文] Impact of ribavirin dose reduction on the efficacy of pegylated interferon plus ribavirin combination therapy for elderly patients infected with genotype 1b and high viral loads (2011)
  • 著者名/発表者名: Kohno H, Kouno H, Aimitsu S, Aisaka Y, Kitamoto M, Kawakami H, Chayama K
  • 雑誌名: Hepatol Res 巻: 41 ページ: 626-634
  • DOI: 10.1111/j.1872-034X.2011.00811.x
  • 査読あり
• [雑誌論文] IL28B but not ITPA polymorphism is predictive of response to pegylated interferon, ribavirin, and telaprevir triple therapy in patients with genotype 1 hepatitis C (2011)
  • 著者名/発表者名: Chayama K, Hayes CN, Abe H, Miki D, Ochi H, Karino Y, Toyota J, Nakamura Y, Kamatani N, Sezaki H, Kobayashi M, Akuta N, Suzuki F, Kumada H
  • 雑誌名: J Infect Dis 巻: 204 ページ: 84-93
  • DOI: 10.1093/infdis/jir210
  • 査読あり
• [雑誌論文] ME3738 enhances the effect of interferon and inhibits hepatitis C virus replication both in vitro and in vivo (2011)
  • 著者名/発表者名: Abe H, Imamura M, Hiraga N, Tsuge M, Mitsui F, Kawaoka T, Takahashi S, Ochi H, Maekawa T, Hayes CN, Tateno C, Yoshizato K, Murakami S, Yamashita N, Matsuhira T, Asai K, Chayama K
  • 雑誌名: J Hepatol 巻: 55 ページ: 11-18
  • DOI: 10.1016/j.jhep.2010.10.017
  • 査読あり
• [雑誌論文] Clinical features and prognosis in patients with hepatocellular carcinoma that developed after hepatitis C virus eradication with interferon therapy (2011)
  • 著者名/発表者名: Nagaoki Y, Aikata H, Miyaki D, Murakami E, Hashimoto Y, Katamura Y, Azakami T, Kawaoka T, Takaki S, Hiramatsu A, Waki K, Imamura M, Kawakami Y, Takahashi S, Chayama K
  • 雑誌名: J Gastroenterol 巻: 46 ページ: 799-808
  • DOI: 10.1007/s00535-011-0384-z
  • 査読あり
• [雑誌論文] Significant regression of a cavernous hepatic hemangioma to a sclerosed hemangioma over 12 years : a case study (2011)
  • 著者名/発表者名: Mlyaki D, Aikata H, Waki K, Murakami E, Hashimoto Y, Nagaoki Y, Katamura Y, Kawaoka T, Takaki S, Hiramatsu A, Imamura M, Takahashi S, Ohya T, Sakimoto H, Arihiro K, Chayama K
  • 雑誌名: Nihon Shokakibyo Gakkai Zasshi 巻: 108 ページ: 954-961
  • 査読あり
• [雑誌論文] Cutaneous complications after transcatheter arterial treatment for hepatocellular carcinoma via the internal mammary artery : how to avoid this complication (2011)
  • 著者名/発表者名: Kajiwara K, Kakizawa H, Takeuchi N, Toyota N, Hieda M, Ishikawa M, Tanitame K, Tani C, Suzuki T, Fujikawa K, Aikata H, Chayama K, Awai K
  • 雑誌名: Jpn J Radiol 巻: 29 ページ: 307-315
  • DOI: 10.1007/s11604-011-0559-9
  • 査読あり
• [雑誌論文] Prediction of response to peginterferon-alfa-2b plus ribavirin therapy in Japanese patients infected with hepatitis C virus genotype 1b (2011)
  • 著者名/発表者名: Hashimoto Y, Ochi H, Abe H, Hayashida Y, Tsuge M, Mitsui F, Hiraga N, Imamura M, Takahashi S, Nelson Hayes C, Ohishi W, Kubo M, Tsunoda T, Kamatani N, Nakamura Y, Chayama K
  • 雑誌名: J Med Virol 巻: 83 ページ: 981-988
  • DOI: 10.1002/jmv.22028
  • 査読あり
• [雑誌論文] Common genetic polymorphism of ITPA gene affects ribavirin-induced anemia and effect of peg-interferon plus ribavirin therapy (2011)
  • 著者名/発表者名: Azakami T, Hayes CN, Sezaki H, Kobayashi M, Akuta N, Suzuki F, Kumada H, Abe H, Miki D, Tsuge M, Imamura M, Kawakami Y, Takahashi S, Ochi H, Nakamura Y, Kamatani N, Chayama K
  • 雑誌名: J Med Virol 巻: 83 ページ: 1048-1057
  • DOI: 10.1002/jmv.22069
  • 査読あり
• [雑誌論文] Elimination of hepatitis C virus by short term NS3-4A and NS5B inhibitor combination therapy in human hepatocyte chimeric mice (2011)
  • 著者名/発表者名: Ohara E, Hiraga N, Imamura M, Iwao E, Kamiya N, Yamada I, Kono T, Onishi M, Hirata D, Mitsui F, Kawaoka T, Tsuge M, Takahashi S, Abe H, Hayes CN, Ochi H, Tateno C, Yoshizato K, Tanaka S, Chayama K
  • 雑誌名: J Hepatol 巻: 54 ページ: 872-878
  • DOI: 10.1016/j.jhep.2010.08.033
  • 査読あり
• [雑誌論文] IL-28B predicts response to chronic hepatitis C therapy--fine-mapping and replication study in Asian populations (2011)
  • 著者名/発表者名: Ochi H, Maekawa T, Abe H, Hayashida Y, Nakano R, Imamura M, Hiraga N, Kawakami Y, Aimitsu S, Kao JH, Kubo M, Tsunoda T, Kumada H, Nakamura Y, Hayes CN, Chayama K
  • 雑誌名: J Gen Virol 巻: 92 ページ: 1071-1081
  • DOI: 10.1099/vir.0.029124-0
  • 査読あり
• [雑誌論文] HCV replication animal model (2011)
  • 著者名/発表者名: Imamura M, Hiraga N, Chayama K
  • 雑誌名: Nihon Rinsho 巻: 69 Suppl 4 ページ: 75-79
  • 査読あり
• [雑誌論文] Impact of radiation and hepatitis virus infection on risk of hepatocellular carcinoma (2011)
  • 著者名/発表者名: Ohishi W, Fujiwara S, Cologne JB, Suzuki G, Akahoshi M, Nishi N, Tsuge M, Chayama K
  • 雑誌名: Hepatology 巻: 53 ページ: 1237-1245
  • DOI: 10.1002/hep.24207
  • 査読あり
• [雑誌論文] A single nucleotide polymorphism in activated Cdc42 associated tyrosine kinase 1 influences the interferon therapy in hepatitis C patients (2011)
  • 著者名/発表者名: Fujimoto Y, Ochi H, Maekawa T, Abe H, Hayes CN, Kumada H, Nakamura Y, Chayama K
  • 雑誌名: J Hepatol 巻: 54 ページ: 629-639
  • DOI: 10.1016/j.jhep.2010.07.021
  • 査読あり
• [雑誌論文] Factors predictive of sustained virological response following 72 weeks of combination therapy for genotype 1b hepatitis C (2011)
  • 著者名/発表者名: Chayama K, Hayes CN, Yoshioka K, Moriwaki H, Okanoue T, Sakisaka S, Takehara T, Oketani M, Toyota J, Izumi N, Hiasa Y, Matsumoto A, Nomura H, Seike M, Ueno Y, Yotsuyanagi H, Kumada H
  • 雑誌名: J Gastroenterol 巻: 46 ページ: 545-555
  • DOI: 10.1007/s00535-010-0358-6
  • 査読あり
• [学会発表] Biological analysis of hepatitis C virus using human hepatocyte chimeric mouse (2012)
  • 著者名/発表者名: 茶山一彰
  • 学会等名: アジア太平洋肝臓病学会議(APASL)
  • 発表場所: 台北、台湾(招待講演)
  • 年月日: 2012-02-19
• [学会発表] Dual Oral Combination Therapy with the NS5A Inhibitor BMS-790052 and the NS3 Protease Inhibitor BMS-650032 Achieved 90% Sustained Virologic Response (SVR12) in HCV Genotype 1b-Infected Null Responders (2011)
  • 著者名/発表者名: 茶山一彰
  • 学会等名: The 62nd Annual Meeting of American Association for the Study of Liver Diseases (AASLD)
  • 発表場所: アメリカ サンフランシスコ(招待講演)
  • 年月日: 2011-11-07
• [学会発表] Biological analysis of hepatitis viruses using human hepatocyte chimeric mouse (2011)
  • 著者名/発表者名: 茶山一彰
  • 学会等名: 第59回国際歯科研究学会日本部会総会・学術大会(JADR2011)
  • 発表場所: 広島(招待講演)
  • 年月日: 2011-10-09
• [備考]
  • URL: http://home.hiroshima-u.ac.jp/naika1/