NASH発症のリスクファクターとしての歯周病菌とその検出の意義

2011 年度 研究成果報告書

• 研究課題/領域番号: 22659150
• 研究種目: 挑戦的萌芽研究
• 配分区分: 補助金
• 研究分野: 消化器内科学
• 研究機関: 横浜市立大学
• 研究代表者: 阿部 泰伸 横浜市立大学, 医学部, 助教 (10347312)
• 研究分担者: 中島 淳 横浜市立大学, 附属病院, 教授 (30326037) ; 和田 孝一郎 大阪大学, 歯学研究科, 准教授 (90263467)
• 研究期間 (年度): 2010 – 2011
• キーワード: 歯周病 / 非アルコール性脂肪肝炎

研究概要

本研究は、NASH患者唾液から歯周病菌を高感度に検出することにより、NASH発症における歯周病菌の関与を明らかにし、歯周病菌感染がNASH発症のリスクファクターとなりうるかどうかを検討した。健常対照60人、NAFLD患者48人、NASH患者102人の唾液を解析したところ歯周病菌の一種P. gingivalisの有菌率が健常人に比べNAFLDで有意に高かった(46.7% vs 21.7% OR=3.16)、さらにNASHでは健常対照に比べさらに有意に多かった(52%, OR=3.91)。NASH患者では高病原性のP. gingivalisであるII型が有意に多かった。異常の結果はBMC Gastroenterologyにて報告した。

研究成果

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• [雑誌論文] Mosapride accelerates the delayed gastric emptying of high-viscosity liquids : a crossover study using continuous real-time C breath test(BreathID System) (2011)
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• [雑誌論文] Time-course of changes of visceral fat area, liver volume and liver fat area during intragastric balloon therapy in Japanese super-obese patients (2011)
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• [雑誌論文] Effects of Histamine-2 Receptor Antagonists and Proton Pump Inhibitors on the Rate of Gastric Emptying : A Crossover Study Using a Continuous Real-Time C Breath Test(BreathID System) (2011)
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• [雑誌論文] Localized primary AL amyloidosis of the colon without other GI involvement (2011)
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• [雑誌論文] Risk factors for mortality in patients with Mallory-Weiss syndrome (2011)
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• [雑誌論文] Change of gastric emptying with chewing gum : evaluation using a continuous real-time C breath test(BreathID system) (2011)
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• [雑誌論文] Efficacy of Lactobacillus casei treatment on small bowel injury in chronic low-dose aspirin users : a pilot randomized controlled study (2011)
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• [雑誌論文] Influence of pretreatment with H2 receptor antagonists on the cure rates of Helicobacter pylori eradication (2011)
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• [雑誌論文] Early effects of oral administration of lafutidine with peppermint oil, compared with lafutidine alone, on intragastric pH values (2011)
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• [雑誌論文] Does postprandial itopride intake affect the rate of gastric emptying? A crossover study using the continuous real time 13C breath test(BreathID system) (2011)
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• [雑誌論文] Optimal approach for small bowel capsule endoscopy using polyethylene glycol and metoclopramide with the assistance of a real-time viewer (2011)
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• [雑誌論文] The collagen-binding protein of Streptococcus mutans is involved in haemorrhagic stroke (2011)
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• [雑誌論文] Leptin acts as a growth factor for colorectal tumours at stages subsequent to tumour initiation in murine colon carcinogenesis (2011)
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• [雑誌論文] Characterization of aortic aneurysms in cardiovascular disease patients harboring Porphyromonas gingivalis (2011)
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• [雑誌論文] Does pretreatment with proton pump inhibitors influence the eradication rate of Helicobacter pylori? (2010)
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  • DOI: DOI:10.1016/j.bmcl.2011.11.045.