冠動脈プラーク退縮におけるコレステロール吸収阻害薬および合成阻害薬の効果

2011 年度 研究成果報告書

• 研究課題/領域番号: 22790713
• 研究種目: 若手研究(B)
• 配分区分: 補助金
• 研究分野: 循環器内科学
• 研究機関: 熊本大学
• 研究代表者: 辻田 賢一 熊本大学, 医学部附属病院, 助教 (60571263)
• 研究期間 (年度): 2010 – 2011
• キーワード: 臨床心血管病態学

研究概要

研究計画書に則り、熊本大学を中心に本研究参加施設からプロトコールI、II合わせて250例の登録を得、登録患者の画像データを本院に設置されたコアラボに収集し定量的IVUS画像解析および定量的冠動脈造影解析を行った。中間解析結果では、一般的な二次予防法であるアトルバスタチン単独療法と比較してエゼチミブ追加療法における低い副作用発現率、より強力なLDL-C低下効果、同等以上のプラーク退縮効果が確認されている。

研究成果

• [雑誌論文] Premenopausal woman with acute myocardial infarction caused by spontaneous coronary artery dissection and potential association with coronary vasospasm (2012)
  • 著者名/発表者名: Tsujita K, Miyazaki T, Kaikita K, Chitose T, Takaoka N, Soejima H, Tayama S, Hokimoto S, Sugiyama S, Ogawa H.
  • 雑誌名: Cardiovasc Interv and Ther 巻: 27 ページ: 121-126
  • DOI: DOI:10.1007/s12928-011-0094-8
  • 査読あり
• [雑誌論文] A survival case of cardiogenic shock due to left main coronary artery myocardial infarction : successful cooperation with on-site percutaneous coronary intervention and helicopter emergency medical service (2012)
  • 著者名/発表者名: Kimura Y, Oba K, Sumida H, Tsujita K, Hirose T, Maruyama H, Hirai S, Kaikita K, Hokimoto S, Sugiyama S, Ogawa H.
  • 雑誌名: Intern Med
  • 査読あり
• [雑誌論文] Subsequent silent plaque rupture of nonculprit lesion in a patient with acute myocardial infarction (2012)
  • 著者名/発表者名: Takaoka N, Tsujita K, Kaikita K, Tayama S, Hokimoto S, Sugiyama S, Ogawa H.
  • 雑誌名: Int J Cardiol 巻: 157 ページ: e60-e62
  • 査読あり
• [雑誌論文] Maintenance of ribosomal protein S19 in plasma by complex formation with prothrombin (2011)
  • 著者名/発表者名: Nishiura H, Tanase S, Tsujita K, Sugiyama S, Ogawa H, Nakagaki T, Semba U, Yamamoto T.
  • 雑誌名: Eur J Haematol 巻: 86 ページ: 436-441
  • DOI: DOI:10.1111/j.1600-0609.2011.01585.x
  • 査読あり
• [雑誌論文] C/EBP homologous protein deficiency attenuates myocardial reperfusion injury by inhibiting myocardial apoptosis and inflammation (2011)
  • 著者名/発表者名: Miyazaki Y, Kaikita K, Endo M, Horio E, Miura M, Tsujita K, Hokimoto S, Yamamuro M, Iwawaki T, Gotoh T, Ogawa H, Oike Y.
  • 雑誌名: Arterioscler Thromb Vasc Biol 巻: 31 ページ: 1124-1132
  • DOI: DOI:10.1161/ATVBAHA.111.224519
  • 査読あり
• [雑誌論文] Current status and prospects of antiplatelet therapy in percutaneous coronary intervention in Japan : focus on adenosine diphosphate receptor inhibitors (2011)
  • 著者名/発表者名: Ogawa H, Hokimoto S, Kaikita K, Yamaoto K, Chitose T, Ono T, Tsujita K.
  • 雑誌名: J Cardiol 巻: 58 ページ: 6-17
  • DOI: DOI:10.1016/j.jjcc.2011.03.002
  • 査読あり
• [雑誌論文] In vivo intravascular ultrasound imaging of fibromuscular dysplastic region and intravascular pressure gradient-guided percutaneous transluminal renal angioplasty (2011)
  • 著者名/発表者名: Onoue Y, Tsujita K, Hokimoto S, Kaikita K, Sugiyama S, Ogawa H.
  • 雑誌名: JC Cases 巻: 4 ページ: e163-e167
  • DOI: DOI:10.1016/j.jccase.2011.08.006
  • 査読あり
• [雑誌論文] Determination of cut-off levels for on-clopidogrel platelet aggregation based on functional CYP2C19 gene variants in patients undergoing elective percutaneous coronary intervention (2011)
  • 著者名/発表者名: Ono T, Kaikita K, Hokimoto S, Iwashita S, Yamamoto K, Miyazaki Y, Horio E, Sato K, Tsujita K, Abe T, Deguchi M, Tayama S, Sumida H, Sugiyama S, Yamabe H, Nakamura S, Nakagawa K, Ogawa H.
  • 雑誌名: Thromb Res 巻: 128 ページ: e130-6
  • DOI: DOI:10.1016/j.thromres.2011.07.028
  • 査読あり
• [雑誌論文] Impact of CYP2C19 polymorphism on residual platelet reactivity in patients with coronary heart disease during antiplatelet therapy (2011)
  • 著者名/発表者名: Yamamoto K, Hokimoto S, Chitose T, Morita K, Ono T, Kaikita K, Tsujita K, Abe T, Deguchi M, Miyagawa H, Saruwatari J, Sumida H, Sugiyama S, Nakagawa K, Ogawa H.
  • 雑誌名: J Cardiol 巻: 57 ページ: 194-201
  • DOI: DOI:10.1016/j.jjcc.2010.10.007
  • 査読あり
• [雑誌論文] Long-term use of oral nicorandil stabilizes coronary plaque in patients with stable angina pectoris (2011)
  • 著者名/発表者名: Izumiya Y, Kojima S, Kojima S, Araki S, Usuku H, Matsubara J, Sakamoto K, Tsujita K, Nagayoshi Y, Kaikita K, Sugiyama S, Ogawa H.
  • 雑誌名: Atherosclerosis 巻: 214 ページ: 415-421
  • DOI: DOI:10.1016/j.atherosclerosis.2010.11.032
  • 査読あり
• [雑誌論文] Serial intravascular ultrasound analysis of the impact of myocardial bridge on neointimal proliferation after coronary stenting in patients with acute myocardial infarction (2010)
  • 著者名/発表者名: Tsujita K, Maehara A, Mintz GS, Lansky AJ, Kubo T, Doi H, Yang J, Bharaj H, Witzenbichler B, Guagliumi G, Brodie BR, Kellett MA, Jr., Parise H, Mehran R, Stone GW.
  • 雑誌名: J Interv Cardiol 巻: 23 ページ: 114-122
  • DOI: DOI:10.1111/j.1540-8183.2010.00531.x
  • 査読あり
• [雑誌論文] Impact of anemia on clinical outcomes of patients with ST-segment elevation myocardial infarction in relation to gender and adjunctive antithrombotic therapy(from the HORIZONS-AMI trial) (2010)
  • 著者名/発表者名: Tsujita K, Nikolsky E, Lansky AJ, Dangas G, Fahy M, Brodie BR, Dudek D, Mockel M, Ochala A, Mehran R, Stone GW.
  • 雑誌名: Am J Cardiol 巻: 105 ページ: 1385-1394
  • DOI: DOI:10.1016/j.amjcard.2010.01.001
  • 査読あり
• [雑誌論文] Prognostic value of plasma von Willebrand factor-cleaving protease(ADAMTS13) antigen levels in patients with coronary artery disease (2010)
  • 著者名/発表者名: Miura M, Kaikita K, Matsukawa M, Soejima K, Fuchigami S, Miyazaki Y, Ono T, Uemura T, Tsujita K, Hokimoto S, Sumida H, Sugiyama S, Matsui K, Yamabe H, Ogawa H.
  • 雑誌名: Thromb Haemost 巻: 103 ページ: 623-629
  • DOI: DOI:10.1160/TH09-08-0568
  • 査読あり
• [雑誌論文] Intravascular ultrasound classification of plaque distribution in left main coronary artery bifurcations. Where is the plaque really located (2010)
  • 著者名/発表者名: Oviedo C, Maehara A, Mintz GS, Araki H, Choi SY, Tsujita K, Kubo H, Doi H, Templin B, Lansky AJ, Dangas G, Leon MB, Mehran R, Tahk SJ, Stone GW, Ochiai M, Moses JW.
  • 雑誌名: Circ Cardiovasc Interv 巻: 3 ページ: 105-112
  • DOI: DOI:10.1161/CIRCINTERVENTIONS.109.906016
  • 査読あり
• [雑誌論文] Dynamic nature of coronary artery lesion morphology assessed by serial virtual histology intravascular ultrasound tissue characterization (2010)
  • 著者名/発表者名: Kubo T, Maehara A, Mintz GS, Doi H, Tsujita K, Choi SY, Katoh O, Nasu K, Koenig A, Pieper M, Rogers JH, Wijns W, Bose D, Margolis MP, Moses JW, Stone GW, Leon MB.
  • 雑誌名: J Am Coll Cardiol 巻: 55 ページ: 1590-1597
  • DOI: DOI:10.1016/j.jacc.2009.07.078
  • 査読あり
• [雑誌論文] Intravascular ultrasound findings of stent fractures in patients with Sirolimus-and Paclitaxel-eluting stents (2010)
  • 著者名/発表者名: Doi H, Maehara A, Mintz GS, Tsujita K, Kubo T, Castellanos C, Lansky AJ, Witzenbichler B, Guagliumi G, Brodie B, Kellett MA Jr, Parise H, Mehran R, Leon MB, Moses JW, Stone GW.
  • 雑誌名: Am J Cardiol 巻: 106 ページ: 952-957
  • DOI: DOI:10.1016/j.amjcard.2010.05.024
  • 査読あり
• [雑誌論文] Is accurate intravascular ultrasound evaluation of the left circumflex ostium from a left anterior descending to left main pullback possible (2010)
  • 著者名/発表者名: Oviedo C, Maehara A, Mintz GS, Tsujita K, Kubo T, Doi H, Castellanos C, Lansky AJ, Mehran R, Dangas G, Leon MB, Stone GW, Templin B, Araki H, Ochiai M, Moses JW.
  • 雑誌名: Am J Cardiol 巻: 105 ページ: 948-954
  • DOI: DOI:10.1016/j.amjcard.2009.11.029
  • 査読あり
• [学会発表] Impact of Cytochrome P450 3A5 Polymorphism on Platelet Aggregation on Maintenance Treatment with Clopidogrel in Patients Undergoing Elective Coronary Stenting (2012)
  • 著者名/発表者名: Chitose T, Hokimoto S, Mizobe M, Yamamoto K, Ono T, Tsujita K, Tayama S, Kaikita K, Nakagawa K, Ogawa H.
  • 学会等名: 61st American College of Cardiology Scientific Sessions
  • 発表場所: Chicago, IL, USA
  • 年月日: 20120324-27
• [学会発表] The Impact of CYP2C19 Polymorphism on Coronary Artery Spasm in Patients with Vasospastic Angina (2012)
  • 著者名/発表者名: Mizobe M, Hokimoto S, Chitose T, Takaoka N, Tsujita K, Kaikita K, Kazuko N, Ogawa H.
  • 学会等名: 61st American College of Cardiology Scientific Sessions
  • 発表場所: Chicago, IL, USA
  • 年月日: 20120324-27
• [学会発表] Intravascular Ultrasound Morphology of Culprit Lesions and Clinical Demographics in Patients With Acute Coronary Syndrome in Relation to Low-Density Lipoprotein Cholesterol Levels at Onset (2012)
  • 著者名/発表者名: Tsujita K, Takaoka N, Kaikita K, Hokimoto S, Chitose T, Ono T, Mizobe M, Horio E, Sato K, Nakayama N, Tayama S, Sugiyama S, Nakamura S, Ogawa H.
  • 学会等名: 61st American College of Cardiology Scientific Sessions
  • 発表場所: Chicago, IL, USA
  • 年月日: 20120324-27
• [学会発表] Acetylcholine-provoked D iffuse Coronary Spasm is Frequently Observed in Female Patients with Coronary Vasospastic Angina without Severe Coronary Organic Stenosis (2012)
  • 著者名/発表者名: Kaikita K, Sato K, Horio E, Ono T, Ohba K, Tsujita K, Hokimoto S, Sugiyama S, Yamabe H, Ogawa H.
  • 学会等名: 76th Annual Scientific Meeting of the Japanese Circulation Society
  • 発表場所: Fukuoka, Japan
  • 年月日: 20120316-18
• [学会発表] Do We Have to Change the Type or Dose of Antiplatelet Agent According to CYP2C19 or 3A5 Genotypes (2012)
  • 著者名/発表者名: Hokimoto S, Mizobe M, Chitose T, Tsujita K, Kaikita K, Nakagawa K, Ogawa H.
  • 学会等名: 76th Annual Scientific Meeting of the Japanese Circulation Society
  • 発表場所: Fukuoka, Japan
  • 年月日: 20120316-18
• [学会発表] The Outcomes of the Dominance of Cross over Strategy for the Un-protected Left Main Coronary Artery (2012)
  • 著者名/発表者名: Tayama S, Kaikita K, Hokimoto S, Tsujita K, Sugiyama S, Tanaka T, Nakamura S, Ogawa H.
  • 学会等名: 76th Annual Scientific Meeting of the Japanese Circulation Society
  • 発表場所: Fukuoka, Japan
  • 年月日: 20120316-18
• [学会発表] Impact of CYP2C19 Polymorphism on In-Stent Restenosis in Patients With Drug-Eluting Stent Implantation. Circulation 2011 ; 124 : A12690 (2011)
  • 著者名/発表者名: Hokimoto S, Mizobe M, Chitose T, Tsujita K, Kaikita K, Nakagawa K, Ogawa H.
  • 学会等名: 84th American Heart Association Scientific Sessions
  • 発表場所: Orlando, FL, USA
  • 年月日: 20111112-16
• [学会発表] Neointimal Tissue Component Assessed by Tissue Characterization With 40MHz Intravascular Ultrasound Imaging-Comparison of Drug-Eluting Stents and Bare-Metal Stents Circulation 2011 ; 124 : A12690. (2011)
  • 著者名/発表者名: Tsujita K, Takaoka N, Kaikita K, Hokimoto S, Ono T, Chitose T, Horio E, Sato K, Mizobe M, Nakayama N, Saito M, Tayama S, Sugiyama S, Yamabe H, Nakamura S, Ogawa H.
  • 学会等名: 84th American Heart Association Scientific Sessions
  • 発表場所: Orlando, FL, USA
  • 年月日: 20111112-16
• [学会発表] Acetylcholine-Provoked Diffuse Coronary Spasm is Frequently Observed in Female Patients with Coronary Vasospastic Angina Without Severe Coronary Organic Stenosis. Circulation 2011 ; 124 : A9683 (2011)
  • 著者名/発表者名: Sato K, Kaikita K, Nakayama N, Horio E, Ono T, Ohba K, Tsujita K, Hokimoto S, Sumida H, Sugiyama S, Yamabe H, Ogawa H.
  • 学会等名: 84th American Heart Association Scientific Sessions
  • 発表場所: Orlando, FL, USA
  • 年月日: 20111112-16
• [学会発表] Angiopoietin-Like Protein2(angptl2)-Induced Vascular Inflammation Causes the Progression of Endothelial Dysfunction and Atherosclerosis. Circulation 2011 ; 124 : A12277 (2011)
  • 著者名/発表者名: Horio E, Kaikita K, Miyata K, Kadomatsu T, Tazume H, Zhe T, Miyazaki Y, Ono T, Sato K, Tsujita K, Tayama S, Hokimoto S, Sugiyama S, Hao H, Takeya M, Ogawa H, Oike Y.
  • 学会等名: 84th American Heart Association Scientific Sessions
  • 発表場所: Orlando, FL, USA
  • 年月日: 20111112-16
• [学会発表] Coronary Plaque Component in Patients with Vasospastic Angina : A Virtual Histology Intravascular Ultrasound Study. Circulation 2011 ; 124 : A15157 (2011)
  • 著者名/発表者名: Tsujita K, Sakamoto K, Kojima S, Kojima S, Nagayoshi Y, Sakamoto T, Tayama S, Kaikita K, Hokimoto S, Sumida H, Sugiyama S, Ogawa H.
  • 学会等名: 84th American Heart Association Scientific Sessions
  • 発表場所: Orlando, FL, USA
  • 年月日: 20111112-16
• [学会発表] Impact of CYP2C19 Polymorphism on Development of Acute Coronary Syndrome(ACS) in Patients with Decreased Plasma Low-Density Lipoprotein Cholesterol(LDL-C). J Am Coll Cardiol 2011 ; 57 : E935 (2011)
  • 著者名/発表者名: Chitose T, Hokimoto S, Yamamoto K, Ono T, Tsujita K, Kaikita K, Sumida H, Sugiyama S, Ogawa H.
  • 学会等名: 60th American College of Cardiology Scientific Sessions
  • 発表場所: New Orleans, LA, USA
  • 年月日: 20110402-05
• [学会発表] Determination of Optimal Cut-Off Value in On-Clopidogrel Platelet Aggregation by VerifyNow P2Y12 System Based on Functional CYP2C19 Gene Variants. J Am Coll Cardiol 2011 ; 57 : E1146 (2011)
  • 著者名/発表者名: Ono T, Kaikita K, Hokimoto S, Yamamoto K, Miyazaki Y, Sakamoto K, Tsujita K, Iwashita S, Sumida H, Sugiyama S, Yamabe H, Ogawa H.
  • 学会等名: 60th American College of Cardiology Scientific Sessions
  • 発表場所: New Orleans, LA, USA
  • 年月日: 20110402-05
• [学会発表] Left Main Plaque Distribution and Stenting Strategy-Insights from Intravascular Ultrasound- (2011)
  • 著者名/発表者名: Tsujita K.
  • 学会等名: Konyang Mayo Tokyo Meeting 2011
  • 発表場所: Konyang, Korea(invited lecture)
  • 年月日: 2011-03-12
• [学会発表] Diastolic to Systolic Velocity Ratio of Coronary Artery Flow at Basal Condition Indicates Coronary Microvessel Spasm in Normal Coronary Angiography. Circulation 2010 ; 122 : A13738 (2010)
  • 著者名/発表者名: Ohba K, Sugiyama S, Nozaki T, Akiyama E, Matsubara J, Maeda H, Sumida H, Takashio S, Kanazawa H, Chitose T, Enomoto K, Ono T, Yamamoto K, Yamamoto E, Tanaka T, Morihisa K, Tsujita K, Nagayoshi Y, Izumiya Y, Yamamuro M, Kojima S, Tayama S, Kaikita K, Hokim
  • 学会等名: 83rd American Heart Association Scientific Sessions
  • 発表場所: Chicago, IL, USA
  • 年月日: 20101113-17
• [学会発表] Functional CYP2C19 Gene Variants are Associated With Both On-clopidogrel Platelet Adhesiveness and Aggregation in Japanese Patients With Coronary Artery Disease. Circulation 2010 ; 122 : A13656 (2010)
  • 著者名/発表者名: Kaikita K, Ono T, Hokimoto S, Tsujita K, Miyazaki Y, Sato K, Horio E, Sumida H, Sugiyama S, Ogawa H.
  • 学会等名: 83rd American Heart Association Scientific Sessions
  • 発表場所: Chicago, IL, USA
  • 年月日: 20101113-17
• [学会発表] C/ebp Homologous Protein Deficiency Attenuates Myocardial Ischemia-Reperfusion Injury by Inhibiting Endoplasmic Reticulum Stress-Induced Apoptosis and Inflammation. Circulation 2010 ; 122 : A12879 (2010)
  • 著者名/発表者名: Miyazaki Y, Kaikita K, Horio E, Yamamuro M, Tsujita K, Hokimoto S, Ogawa H, Oike Y.
  • 学会等名: 83rd American Heart Association Scientific Sessions
  • 発表場所: Chicago, IL, USA
  • 年月日: 20101113-17
• [学会発表] Angiopoietin-Like Protein2(angptl2) Promotes Coronary Endothlial Dysfunction and Atherosclerosis. Circulation 2010 ; 122 : A11343 (2010)
  • 著者名/発表者名: Horio E, Kaikita K, Tabata M, Zhe T, Tazume H, Miyata K, Miyazaki Y, Ono T, Sato K, Tsujita K, Hokimoto S, Sumida H, Sugiyama S, Ogawa H, Oike Y.
  • 学会等名: 83rd American Heart Association Scientific Sessions
  • 発表場所: Chicago, IL, USA
  • 年月日: 20101113-17
• [学会発表] Plaque Distribution in Left Main Trunk and Treatment Strategy (2010)
  • 著者名/発表者名: Tsujita K, Tayama S, Kaikita K, Hokimoto S, Sumida H, Sugiyama S, Nakamura S, Ogawa H.
  • 学会等名: 24th Japanese Coronary Association
  • 発表場所: Tokyo, Japan(invited lecture)
  • 年月日: 2010-12-10
• [学会発表] Chronic Total Coronary Occlusion : Lesion Morphology Evaluated by Intravascular Ultrasound (2010)
  • 著者名/発表者名: Tsujita K.
  • 学会等名: 4th Coronary Interventional Imaging CIVUS Heart Lecture
  • 発表場所: Seoul, Korea(invited lecture)
  • 年月日: 2010-06-05
• [図書] 心疾患における抗凝固・抗血小板療法,血栓止血誌 (2012)
  • 著者名/発表者名: 副島弘文, 海北幸一, 掃本誠治, 辻田賢一, 小川久雄
  • 総ページ数: 25-32
• [図書] 狭心症の薬物治療 (2010)
  • 著者名/発表者名: 辻田賢一, 海北幸一, 小川久雄
  • 総ページ数: 1588-1593
  • 出版者: medicina
• [図書] 循環器薬の使い方.コツと落とし穴-1.循環器疾患の薬物治療-Overview-d.狭心症 (2010)
  • 著者名/発表者名: 山本英一郎, 辻田賢一, 千年忠祐, 掃本誠治, 小川久雄
  • 総ページ数: 30-34
  • 出版者: Heart View