• 研究課題をさがす
  • 研究者をさがす
  • KAKENの使い方
  1. 課題ページに戻る

2023 年度 実績報告書

Unleashing the power of AI to create a novel treatment for hemophilia A

研究課題

研究課題/領域番号 22K06119
研究機関国立研究開発法人国立成育医療研究センター

研究代表者

daSilvaLopes TiagoJose  国立研究開発法人国立成育医療研究センター, 細胞医療研究部, 専門職 (10903429)

研究期間 (年度) 2022-04-01 – 2024-03-31
キーワードHemophilia A / Artificial intelligence / Machine learning / Bioinformatics / Protein design
研究実績の概要

This project demonstrated the viability of using artificial intelligence to design therapeutic proteins for a rare disease. We used the latest methods to generate almost 200 candidate molecules, that are now undergoing in vitro testing by a collaborator at the Jichi Medical University Hospital. This number consists a dramatic reduction in the number of candidates that is traditionally tested in pre-clinical studies.
Importantly, we generated our therapeutic proteins using a technique called cell-free expression, which does not involve the use of any bacteria or mammalian cell lines; this further reduced the costs and labor involved in the process.
Overall, we are satisfied with the progress of this project, the conscious use of resources and the training of younger researchers.

  • 研究成果

    (3件)

すべて 2023

すべて 雑誌論文 (2件) (うち国際共著 2件、 査読あり 2件、 オープンアクセス 2件) 学会発表 (1件) (うち国際学会 1件)

  • [雑誌論文] Full-scale network analysis reveals properties of the FV protein structure organization.2023

    • 著者名/発表者名
      Ferreira-Martins AJ, Castaldoni R, Alencar BM, Ferreira MV, Nogueira T, Rios RA, Lopes TJS.
    • 雑誌名

      Sci Rep

      巻: 13 ページ: 9546

    • DOI

      10.1038/s41598-023-36528-z

    • 査読あり / オープンアクセス / 国際共著
  • [雑誌論文] A graph-based machine learning framework identifies critical properties of FVIII that lead to hemophilia A.2023

    • 著者名/発表者名
      Ferreira MV, Nogueira T, Rios RA, Lopes TJS.
    • 雑誌名

      Front Bioinform

      巻: 3 ページ: 1152039

    • DOI

      10.3389/fbinf.2023.1152039

    • 査読あり / オープンアクセス / 国際共著
  • [学会発表] Modeling Protein Activities and Mutations with Graph Neural Networks: Insights into Hemophilia2023

    • 著者名/発表者名
      Marcos V. Ferreira; Tiago J. S. Lopes; Ricardo A. Rios; Tatiane N. Rios
    • 学会等名
      IJCNN 2023
    • 国際学会

URL: 

公開日: 2024-12-25  

サービス概要 検索マニュアル よくある質問 お知らせ 利用規程 科研費による研究の帰属

Powered by NII kakenhi