| 研究実績の概要 |
This year, we successfully integrated 2D traveling wave devices into 24-well plates for high-throughput assays. The traveling wave could be maintained stably for long periods. We also attempted to prepare a smaller device for 96-well plates. However, due to the shorter closed-loop circuit in the 96-well plate, we found that the traveling wave became unstable and disappeared after prolonged culture. Therefore, we utilized the 24-well plate device for subsequent electrophysiology assays on MEA system. iPSC-derived cardiomyocytes have been paced and matured. After a 14-day training period, the mature cardiac tissue was used for recording electrophysiological signals, which were clear and well-defined, indicating readiness for subsequent drug testing.
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