| 研究課題/領域番号 |
22K14742
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| 研究機関 | 長崎大学 |
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研究代表者 |
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| 研究期間 (年度) |
2022-04-01 – 2026-03-31
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| キーワード | cancer therapy / noble metal / prodrug / templated crystallize / nanomedicine |
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| 研究実績の概要 |
The purpose of this research is to design and fabricate a carrier-free nanodrug via templated-crystallization method using SN-38, the active metabolite of irinotecan, acts as a potent inhibitor of DNA topoisomerase I. In this work, several derivatives of SN-38 were selected as the anticancer moiety, and Au cluster of ca. 10 nm was selected as a template. The nanodrugs are fabricated by reprecipitation method.
The formation yield of the hybrid nanodrugs were improved by adjusting the reprecipitation conditions, such as the good solvent of Au nanoparticles. The morphology of Au/SN-38Chol nanoparticles was confirmed SEM and showed a narrow size distribution and template-guided shape. Photothermal effect was investigated and exhibited a sufficient performance in comparison to pure Au nanoparticles.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
1: 当初の計画以上に進展している
理由
The second targets of the research plan are close to being complete, including observation of charge transfer effect between noble metal nanoparticles and drug molecules. The research is progressing to the profiling of the drug release kinetic at different conditions.
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| 今後の研究の推進方策 |
The next targets of the research are investigation of charge transfer effect by UV-Vis, XPS, and FT-IR. The results are correlated with the drug release rate and composition of SN-38 hybrid NPs.
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| 次年度使用額が生じた理由 |
A small amount of budget was transferred to the next fiscal year for some small equipment and materials that could not be purchased due to limited supplies.
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