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2023 年度 実績報告書

天然資源と金属ナノ粒子触媒を用いる非天然創薬リート化合物の創製

研究課題

研究課題/領域番号 22K15252
研究機関大阪大学

研究代表者

SIRIMANGKALAKITTI NATCHANUN  大阪大学, 大学院薬学研究科, 特任助教 (10909120)

研究期間 (年度) 2022-04-01 – 2024-03-31
キーワードnatural product extract / chemical diversification / metal catalyst / lead compound
研究実績の概要

Our recent research extends previous success in diversification of natural product extracts. We have focused on employing Palladium nanoparticle catalyst for enhanced chemical diversification. These catalyst offers efficient catalysis of C-H bond activation, C-C cleavage, and cross-coupling reactions, facilitating the creation of diverse molecular scaffolds through C-C and/or C-heteroatom bond formations, thus generating new molecular structures. Additionally, we are currently developing highly reactive Rhodium nanoparticle catalyst, which hold promise for further expanding the scope and efficacy of chemical diversification. Our research underscores the potential of nanoparticle catalysts in driving innovative and sustainable approaches, with implications for advancing the exploration and exploitation of natural product diversity for pharmaceutical applications.

  • 研究成果

    (2件)

すべて 2023

すべて 学会発表 (2件) (うち国際学会 1件)

  • [学会発表] A New Tetracyclic Bromopyrrole-Imidazole Derivative through Direct Chemical Diversification of Substances Present in Natural Product Extract from Marine Sponge Petrosia (Strongylophora) sp.2023

    • 著者名/発表者名
      Natchanun Sirimangkalakitti
    • 学会等名
      The American Society of Pharmacognosy 2023 Annual Meeting Innovation Through Interaction
    • 国際学会
  • [学会発表] A New Tetracyclic Bromopyrrole-Imidazole Derivative through Direct Chemical Diversification of Substances Present in Natural Product Extract from Marine Sponge Petrosia (Strongylophora) sp.2023

    • 著者名/発表者名
      Natchanun Sirimangkalakitti
    • 学会等名
      24th Symposium on the Development and Application of Naturally Occurring Drug Materials

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公開日: 2024-12-25  

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