| 研究課題/領域番号 |
22K15448
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| 研究機関 | 東京大学 |
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研究代表者 |
LEE MICHELLE 東京大学, 医科学研究所, 特任助教 (10821423)
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| 研究期間 (年度) |
2022-04-01 – 2024-03-31
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| キーワード | bone marrow / hematopoietic niche / malaria |
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| 研究実績の概要 |
We recently found that the some bone marrow niches are disrupted by malaria, which results in the alteration of bone marrow hematopoiesis and suppression of lymphopoiesis. Therefore we further aim to elucidate the mechanisms causing the alteration of certain niches in the bone marrow during blood stage Plasmodium infection. We examined the differential gene expressions of specific bone marrow cell population sorted by flow cytometry. Using genetically modified mice, we are now elucidating the role of some genes in the bone marrow during malaria.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
Experiments were progressing rather smoothly as expected.
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| 今後の研究の推進方策 |
Next we plan to identify the host and parasites factors that contribute to the alteration of bone marrow niche. Furthermore, we are also evaluating the long term effects of such alteration in the bone marrow on the host immune responses.
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| 次年度使用額が生じた理由 |
The remaining amount will be used for purchasing research reagents.
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