| 研究実績の概要 |
Systemic Lupus Erythematosus is an autoimmune disease in which B cells play an integral role through autoantibody secretion. Our lab has previously provided evidence of the involvement of CD72, an inhibitory B cell receptor in SLE development. In this project, we investigated the possibility that CD72 is a receptor for C1q ( a complement protein that binds to apoptotic cells ). Invitro studies showed an interaction between CD72 and C1q. For further investigation, functional analysis was done to study if a fusion protein composed of CD72 and C1q can inhibit B cell responses to apoptotic cells. To extend the scope of the study to an in vivo level, a targeting vector expressing a fusion protein composed of the globular domain of C1q fused to the CD72 receptor was created.
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