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2023 年度 実績報告書

Establishing a low-cost next-generation sequencing platform for on-site real-time surveillance of SARS-CoV-2 and other viruses in an unreached community from the Democratic Republic of Congo

研究課題

研究課題/領域番号 22K17352
研究機関大阪公立大学

研究代表者

チバング・カバンバ エバリステ  大阪公立大学, 大学院医学研究科, 特任助教 (50900693)

研究期間 (年度) 2022-04-01 – 2024-03-31
キーワードViral genome / Nanopore sequecing / Congo / Hepatitis B virus / Monkeypox virus
研究実績の概要

In FY 2023, studies were conducted in Africa applying our developed toolkit. With the decline of the SARS-CoV-2 pandemic, our interest shifted towards investigating additional endemic viruses, including hepatitis B virus, Monkeypox virus, and other viruses potentially transmitted from mother to child. Overall, 1077 individuals, comprising 200 pregnant women and 200 newborns, participated in surveys conducted in rural populations of the DRC. However, challenges arose in deploying our virus sequencing toolkit directly in the field, primarily due to the complexities of safely delivering sequencing kits in specific storage conditions. Therefore, we decided to collect and transport samples to Japan for analysis using the toolkit, albeit resulting in prolonged wait times for sample transfer.

  • 研究成果

    (10件)

すべて 2024 2023 その他

すべて 国際共同研究 (1件) 雑誌論文 (7件) (うち国際共著 7件、 オープンアクセス 7件) 学会発表 (2件) (うち招待講演 2件)

  • [国際共同研究] University of Mbujimayi/INRB(コンゴ民主共和国)

    • 国名
      コンゴ民主共和国
    • 外国機関名
      University of Mbujimayi/INRB
  • [雑誌論文] Malaria infection among adults residing in a highly endemic region from the Democratic Republic of the Congo2024

    • 著者名/発表者名
      Kayiba Nadine Kalenda、Nitahara Yuko、Tshibangu-Kabamba Evariste、Mbuyi Denis Kalambayi、Kabongo-Tshibaka Augustin、Kalala Nestor Tshituka、Tshiebue Barth?lemy Mukenga、Candray-Medina Katherine-Sofia、Kaku Natsuko、Nakagama Yu、Speybroeck Niko、Mumba Dieudonn? Ngoyi、Disashi Ghislain Tumba、Kaneko Akira、Kido Yasutoshi
    • 雑誌名

      Malaria Journal

      巻: 23 ページ: 1~14

    • DOI

      10.1186/s12936-024-04881-7

    • オープンアクセス / 国際共著
  • [雑誌論文] Genetic determinants of Biofilm formation of Helicobacter pylori using whole-genome sequencing2023

    • 著者名/発表者名
      Fauzia Kartika Afrida、Aftab Hafeza、Miftahussurur Muhammad、Waskito Langgeng Agung、Tuan Vo Phuoc、Alfaray Ricky Indra、Matsumoto Takashi、Yurugi Michiyuki、Subsomwong Phawinee、Kabamba Evariste Tshibangu、Akada Junko、Yamaoka Yoshio
    • 雑誌名

      BMC Microbiology

      巻: 23 ページ: 1~10

    • DOI

      10.1186/s12866-023-02889-8

    • オープンアクセス / 国際共著
  • [雑誌論文] The Helicobacter pylori Genome Project: insights into H. pylori population structure from analysis of a worldwide collection of complete genomes2023

    • 著者名/発表者名
      The HpGP Research Network
    • 雑誌名

      Nature Communications

      巻: 14 ページ: 1~16

    • DOI

      10.1038/s41467-023-43562-y

    • オープンアクセス / 国際共著
  • [雑誌論文] Usefulness of seasonal malaria chemoprevention in the Sahel2023

    • 著者名/発表者名
      Kalenda Nadine Kayiba、Tshibangu-Kabamba Evariste、Nakagama Yu、Kaku Natsuko、Kaneko Akira、Speybroeck Niko、Kido Yasutoshi
    • 雑誌名

      The Lancet Infectious Diseases

      巻: 23 ページ: 269~270

    • DOI

      10.1016/S1473-3099(22)00654-5

    • オープンアクセス / 国際共著
  • [雑誌論文] The landscape of drug resistance in Plasmodium falciparum malaria in the Democratic Republic of Congo: a mapping systematic review2023

    • 著者名/発表者名
      Kayiba Nadine Kalenda、Tshibangu-Kabamba Evariste、Rosas-Aguirre Angel、Kaku Natsuko、Nakagama Yu、Kaneko Akira、Makaba Dieudonne Mvumbi、Malekita Doudou Yobi、Devleesschauwer Brecht、Likwela Joris Losimba、Zakayi Pius Kabututu、Kido Yasutoshi、Speybroeck Niko
    • 雑誌名

      Tropical Medicine and Health

      巻: 51 ページ: 1~16

    • DOI

      10.1186/s41182-023-00551-7

    • オープンアクセス / 国際共著
  • [雑誌論文] Comparative genomics of two Vietnamese Helicobacter pylori strains, CHC155 from a non-cardia gastric cancer patient and VN1291 from a duodenal ulcer patient2023

    • 著者名/発表者名
      Phuc Bui Hoang、Tuan Vo Phuoc、Binh Tran Thanh、Tung Pham Huu、Tri Tran Dinh、Dung Ho Dang Quy、Thuan Ngo Phuong Minh、Fauzia Kartika Afrida、Tshibangu-Kabamba Evariste、Alfaray Ricky Indra、Saruuljavkhlan Batsaikhan、Matsumoto Takashi、Akada Junko、Yamaoka Yoshio
    • 雑誌名

      Scientific Reports

      巻: 13 ページ: 1~13

    • DOI

      10.1038/s41598-023-35527-4

    • オープンアクセス / 国際共著
  • [雑誌論文] Differential cardiomyocyte transcriptomic remodeling during in vitro Trypanosoma cruzi infection using laboratory strains provides implications on pathogenic host responses2023

    • 著者名/発表者名
      Candray-Medina Katherine-Sofia、Nakagama Yu、Ito Masamichi、Nakagama Shun、Tshibangu-Kabamba Evariste、Takeda Norihiko、Sugiura Yuki、Nitahara Yuko、Michimuko-Nagahara Yu、Kaku Natsuko、Onizuka Yoko、Nakajima-Shimada Junko、Kido Yasutoshi
    • 雑誌名

      Tropical Medicine and Health

      巻: 51 ページ: 1~17

    • DOI

      10.1186/s41182-023-00552-6

    • オープンアクセス / 国際共著
  • [学会発表] Antibiotic stewardship in African Helicobacter pylori infections2023

    • 著者名/発表者名
      Evariste Tshibangu-Kabamba
    • 学会等名
      Congolese Observatory of H. pylori and gastric cancer
    • 招待講演
  • [学会発表] Helicobacter pylori in Africa: Is it time for precision medicine?2023

    • 著者名/発表者名
      Evariste Tshibangu-Kabamba
    • 学会等名
      The African Helicobcater and Microbiota Study Group
    • 招待講演

URL: 

公開日: 2024-12-25  

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